本文選題：主成分分析 + 心肌梗死　； 參考：《遼寧中醫(yī)雜志》2017年10期

【摘要】：目的:調(diào)查中醫(yī)院心肌梗死患者住院期間及隨訪期間終點事件的發(fā)生情況,運用主成分分析結(jié)合頻數(shù)統(tǒng)計構(gòu)建心肌梗死中醫(yī)臨床療效評價的終點指標。方法:采用病案調(diào)查及隨訪研究。納入山東中醫(yī)藥大學附屬醫(yī)院、淄博市中醫(yī)院、日照市中醫(yī)院、青島市中醫(yī)院、濟南市中醫(yī)院、濟寧市中醫(yī)院6家中醫(yī)院,2008年1月1日—2014年12月31日入院,出院診斷為心肌梗死患者。制作中醫(yī)醫(yī)院心肌梗死患者調(diào)查表。收集患者住院期間及隨訪期間一般資料及終點事件發(fā)生情況。將數(shù)據(jù)輸入Excel2003及SPSS17.0軟件包。運用主成分分析分別計算住院期間及隨訪期間各終點指標的權(quán)重,統(tǒng)計各指標發(fā)生頻數(shù),利用乘數(shù)合成歸一法計算各指標的綜合權(quán)重,結(jié)合臨床意義,建立心肌梗死中醫(yī)臨床療效評價的終點指標。結(jié)果:(1)住院期間:綜合權(quán)重大小依次為梗死后心絞痛(0.2175)、血運重建(0.1624)、心源性死亡(0.1360)等。(2)隨訪期間:隨訪6個月內(nèi)綜合權(quán)重大小依次為再住院次數(shù)(0.3887)、梗死后心絞痛(0.149)、心源性死亡(0.1434)等。隨訪1年內(nèi)綜合權(quán)重大小依次為再住院次數(shù)(0.5229)、心源性死亡(0.1271)、梗死后心絞痛(0.1212)等。隨訪1年以上綜合權(quán)重大小依次為再住院次數(shù)(0.4374)、再梗死(0.1702)、心源性死亡(0.17)等。結(jié)論:(1)住院期間:主要評價指標為心源性死亡、嚴重心律失常、急性心力衰竭,次要評價指標為心源性休克、梗死后心絞痛、血運重建。(2)隨訪期間:隨訪6個月內(nèi)主要評價指標為心源性死亡、心力衰竭、嚴重心律失常,次要評價指標為再梗死、腦卒中、血運重建等。隨訪1年內(nèi)主要評價指標為心源性死亡、再梗死、心力衰竭,次要評價指標為腦卒中、血運重建、梗死后心絞痛等。隨訪1年以上主要評價指標為再梗死、心源性死亡、嚴重心律失常,次要評價指標為腦卒中、梗死后心絞痛、血運重建等。
[Abstract]:Objective: to investigate the incidence of end-point events during hospitalization and follow-up in patients with myocardial infarction in traditional Chinese Medicine (TCM), and to construct the endpoints of TCM clinical efficacy evaluation of myocardial infarction by principal component analysis (PCA) combined with frequency statistics. Methods: medical record investigation and follow-up study were used. It is included in the affiliated hospitals of Shandong University of traditional Chinese Medicine, Zibo City traditional Chinese Medicine Hospital, Rizhao traditional Chinese Medicine Hospital, Qingdao traditional Chinese Medicine Hospital, Jinan City traditional Chinese Medicine Hospital, Jining traditional Chinese Medicine Hospital, 6 Chinese Medicine Hospitals from January 1, 2008 to December 31, 2014. The patients were diagnosed as myocardial infarction. To make the questionnaire of myocardial infarction patients in TCM hospital. Collect the general data and the occurrence of terminal events during hospitalization and follow-up. Input data into Excel2003 and SPSS17.0 software package. Principal component analysis (PCA) was used to calculate the weight of each end-point index during hospitalization and follow-up period, to calculate the occurrence frequency of each index, to calculate the comprehensive weight of each index by the method of multiplier synthesis normalization, and to combine with clinical significance. To establish endpoints for evaluating the clinical efficacy of myocardial infarction in traditional Chinese medicine (TCM). Results during the period of hospitalization, the overall weight was 0.2175U, 0.1624g, 0.1360).) during the follow-up period, the overall weight was 0.3887g, 0.149m, 0.149and 0.3887g respectively, and the weight was 0.2175U, 0.1624g, 0.1360) during the 6-month follow up, the total weight was 0.3887g, 0.149, 0.149a, respectively. Cardiac death 0.1434). The weight of the patients was 0.5229m, 0.1271g, 0.121212) during one year follow up and so on. The order of weight was: rehospitalization times (0.5229g), cardiogenic death (0.1271g). The comprehensive weight values of more than one year follow up were as follows: the number of rehospitalization was 0.4374, the number of re-infarction was 0.1702, the cardiac death was 0.17). Conclusion: during hospitalization, the main evaluation indexes were cardiogenic death, severe arrhythmia, acute heart failure, secondary evaluation index was cardiogenic shock, postinfarction angina pectoris, the main evaluation index was cardiogenic death, severe arrhythmia, acute heart failure, and postinfarction angina pectoris. During the follow-up period, the main indexes were cardiogenic death, heart failure, severe arrhythmia, and secondary indexes were re-infarction, stroke and revascularization. The main evaluation indexes were cardiac death, reinfarction, heart failure, and the secondary indexes were stroke, revascularization, postinfarction angina pectoris and so on. The main evaluation indexes were re-infarction, cardiogenic death, severe arrhythmia, and the secondary evaluation indexes were stroke, post-infarction angina pectoris, revascularization and so on.
【作者單位】： 山東中醫(yī)藥大學第一臨床醫(yī)學院;山東中醫(yī)藥大學附屬醫(yī)院心內(nèi)科;山東中醫(yī)藥大學;
【基金】：國家自然科學基金(81373827) 山東省一流學科資助項目(中醫(yī)學)
【分類號】：R259
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本文編號：1908698