本文選題：腎陽虛型 + PCOS�。� 參考：《河南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:觀察助孕湯對腎陽虛型PCOS所致不孕癥患者臨床癥狀改善、中醫(yī)證候積分、體重指數(shù)(BMI)、基礎(chǔ)體溫(BBT)、妊娠率、流產(chǎn)率、卵泡最大直徑、排卵當(dāng)天子宮內(nèi)膜厚度、性激素水平及安全性指標(biāo)的影響,分析并評價其療效及安全性,為中醫(yī)藥辨證治療本病提供思路及方法。方法:選擇2014年1月至2016年1月期間,于河南省中醫(yī)院婦科門診就診,且符合納入及排除標(biāo)準(zhǔn)的患者60例,按照就診時間順序納入本課題。采用隨機(jī)數(shù)字表法分組,試驗(yàn)組與對照組各30例。用雙盲法研究觀察,試驗(yàn)組給予助孕湯治療,對照組給予龍鹿膠囊治療,均于月經(jīng)來潮第5日服至下一次月經(jīng)來潮,助孕湯日一劑,水煎取汁400ml,早、晚各200ml溫服,龍鹿膠囊每次5粒,每日3次,口服。治療3個月為一個療程,共計(jì)9個月。若患者治療期間妊娠,則停止服藥;若患者發(fā)生不良事件,及時治療并評估是否繼續(xù)治療;若發(fā)生嚴(yán)重不良事件,則退出試驗(yàn)。采用統(tǒng)一指標(biāo),觀察兩組患者治療前及治療后的臨床癥狀改善、中醫(yī)證候積分、體重指數(shù)(BMI)、基礎(chǔ)體溫(BBT)、妊娠率、流產(chǎn)率、主卵泡最大直徑、排卵當(dāng)天子宮內(nèi)膜厚度、性激素水平情況及安全性指標(biāo)情況,對觀察結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)分析,評價其療效及安全性,得出相關(guān)結(jié)論。結(jié)果:1臨床療效對比:治療結(jié)束后,治療組痊愈有8例,顯效14例,無效2例,有效6例,治愈率為26.67%,有效率為93.33%。對照組痊愈3例,顯效8例,有效14例,無效5例,治愈率為10%,總有效率為83.33%。兩組患者的臨床療效分布對比經(jīng)χ~2檢驗(yàn),χ~2=8.395,P0.05,有統(tǒng)計(jì)學(xué)差異。2中醫(yī)證候積分及妊娠率、流產(chǎn)率比較:治療后兩組患者中醫(yī)癥候積分均較治療前有所降低,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。且治療組患者中醫(yī)癥候積分降低較對照組多,具有統(tǒng)計(jì)學(xué)差異(P0.05)。治療組總?cè)焉?例,流產(chǎn)0例,妊娠率26.67%,流產(chǎn)率0%,對照組妊娠2例,流產(chǎn)1例,妊娠率6.67%,流產(chǎn)率50%。治療組的妊娠率高于對照組,流產(chǎn)率低于對照組,均有P0.05,差異有統(tǒng)計(jì)學(xué)意義。3臨床檢查指標(biāo)比較:試驗(yàn)結(jié)束后,兩組患者卵巢主卵泡最大直徑、BBT雙相例數(shù)均較治療前有所增加,且治療組較對照組增加較多,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,試驗(yàn)組排卵當(dāng)天內(nèi)膜較治療前有所增厚,有統(tǒng)計(jì)學(xué)差異(P0.05),兩組患者排卵當(dāng)天內(nèi)膜增厚對比,無明顯統(tǒng)計(jì)學(xué)差異(P0.05)。治療后兩組患者LH、P、T、PRL對比均有統(tǒng)計(jì)學(xué)差異(P0.05),E_2、FSH對比無明顯差異(P0.05)。試驗(yàn)組治療前后對比,LH、P、T、PRL對比均有P0.01,有顯著統(tǒng)計(jì)學(xué)差異,E_2、FSH與治療前相比無明顯差異;對照組FSH、LH、T、PRL對比,有統(tǒng)計(jì)學(xué)差異(P0.05),而P、E_2與治療前相比無明顯差異。4安全性指標(biāo):治療組及對照組血、尿、糞便常規(guī)及心電圖、肝腎功能均未見明顯異常,未見患者有不良反應(yīng)。兩組藥物安全性較好。結(jié)論:通過對助孕湯治療腎陽虛型PCOS不孕癥的臨床觀察,研究材料表明助孕湯能有效治療腎陽虛型PCOS不孕癥,促進(jìn)卵巢主卵泡最大直徑增加,增加排卵當(dāng)天子宮內(nèi)膜厚度,改變BBT單相性,改善患者生殖內(nèi)分泌水平,提高妊娠率,降低流產(chǎn)率,顯著改善患者的臨床癥狀和體征。治療期間未發(fā)現(xiàn)患者有不良反應(yīng),且安全性監(jiān)測指標(biāo)示該藥無明顯毒副作用。本研究表明助孕湯臨床療效顯著,無明顯毒副作用,值得進(jìn)一步研究及推行。
[Abstract]:Objective: To observe the improvement of clinical symptoms of infertility caused by kidney yang deficiency type PCOS, TCM syndrome score, body mass index (BMI), basic body temperature (BBT), pregnancy rate, abortion rate, maximum follicle diameter, endometrial thickness, sex hormone level and safety index in the day of ovulation, analysis and evaluation of its efficacy and safety, for traditional Chinese medicine. Methods: to provide ideas and methods for the treatment of this disease. Methods: from January 2014 to January 2016, 60 patients in the Department of gynaecologic clinic in Henan Traditional Chinese Medicine Hospital were treated in the Department of gynecologic clinic in Henan Traditional Chinese Medicine Hospital, and the patients were in accordance with the inclusion and exclusion criteria. The randomized digital table was used to group the patients. The test group and the control group were divided into 30 cases. The group was given the decoction of help pregnant soup, and the control group was given the long Lu Lu capsule treatment, all of which were taken to the next menstrual tide on fifth days of menstruation, one dose of soup day, 400ml, early and late 200ml, 3 times a day, 3 times a day for 3 months, for a total of 9 months. If an adverse event occurred, the patient was treated and evaluated in time to continue the treatment; if a serious adverse event occurred, the trial was withdrawn. A unified index was used to observe the improvement of the clinical symptoms before and after the treatment of the two groups, the TCM syndrome score, the body mass index (BMI), the basal body temperature (BBT), the pregnancy rate, the abortion rate, the largest diameter of the main follicle, ovulation. On the day of endometrium thickness, sex hormone level and safety index, the observation results were statistically analyzed, and the efficacy and safety were evaluated. Results: 1 clinical curative effects were compared: after the treatment, 8 cases were cured, 14 cases were markedly effective, 2 cases were not effective, 6 cases were effective, the cure rate was 26.67%, the effective rate was 93.33%. control Group healed 3 cases, effective 8 cases, effective 14 cases, invalid 5 cases, the cure rate was 10%, the total effective rate was 83.33%. two group, the clinical curative effect distribution compared through the X ~2 test, X ~2=8.395, P0.05, there were statistically different.2 TCM syndrome integral and pregnancy rate, abortion rate comparison: after treatment two groups of TCM syndrome scores were lower than before treatment, the difference was Statistical significance (P0.05). And in the treatment group, the score of TCM syndrome decreased more than the control group (P0.05). There were 8 cases of total pregnancy, 0 cases of abortion, 26.67% pregnancy rate, 0% abortion rate, 2 pregnant women in the control group, 1 abortion, 6.67% pregnancy rate, the rate of abortion rate 50%. was higher than that of the control group, the abortion rate was lower than the control group, all abortion rates were lower than the control group, all the abortion rates were lower than the control group, all the abortion rates were lower than the control group, all the abortion rates were lower than the control group, all the abortions were lower than the control group, all the abortion rates were lower than the control group, all the abortion rates were lower than the control group, all the abortion rates were lower than the control group, all the abortion rates were lower than the control group, all the abortion rates were lower than the control group, all P0.05, the difference was statistically significant.3 clinical examination index: after the test, the maximum diameter of the ovarian main follicle in the two groups, the number of BBT biphasic cases increased more than before the treatment, and the treatment group increased more than the control group, the difference was statistically significant (P0.05). After the treatment, the endometrium in the test group was thicker than before the treatment, statistically significant. Difference (P0.05), there was no significant difference between the two groups of patients on the day of ovulation, and there was no significant difference (P0.05). There were statistically significant differences (P0.05), E_2, FSH contrast between the two groups after treatment (P0.05), E_2, and FSH (P0.05). There was no significant difference in the comparison of FSH, LH, T and PRL in the control group (P0.05), while P, E_2 had no significant difference in.4 safety indexes compared with before treatment: the blood, urine, stool routine and electrocardiogram were not found in the treatment group and the control group, the liver and kidney function were not obvious abnormality, no adverse reaction was found in the patients. The two groups of drugs were safe. Clinical observation on the treatment of kidney yang deficiency type PCOS infertility, the research material shows that the decoction can effectively treat the kidney yang deficiency type PCOS infertility, promote the increase of the maximum diameter of the ovarian main follicle, increase the thickness of the endometrium on the day of ovulation, change the BBT single phase, improve the level of the reproductive endocrine, improve the pregnancy rate, reduce the abortion rate and significantly improve the patient. Clinical symptoms and signs. No adverse reaction was found during the treatment, and safety monitoring indicated that the drug had no obvious toxic and side effects. This study showed that the decoction has significant clinical effect and no obvious side effects. It is worth further study and implementation.

【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R271.14

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 金維良;張林;;二仙加皮酒治療腎陽虛型男子性功能下降32例[J];中醫(yī)藥研究;1993年02期

2 劉興武;腎陽虛型高血壓驗(yàn)案2則[J];四川中醫(yī);1996年07期

3 劉清池;孫曉靜;;補(bǔ)骨脂治療腎陽虛型慢性再生障礙性貧血[J];中醫(yī)雜志;2002年05期

4 牟汝春;;春生丸治療腎陽虛型男性不育100例臨床分析[J];青島醫(yī)藥衛(wèi)生;1998年09期

5 冼紹祥;歐明;;腎陽虛型心力衰竭病證結(jié)合動物模型的建立和評價[J];遼寧中醫(yī)藥大學(xué)學(xué)報;2007年01期

6 周冰峰;鄭小陸;鐘啟騰;王斌;陳翠萍;王子耀;;前列消治療良性前列腺增生癥(腎陽虛型)50例[J];中醫(yī)藥導(dǎo)報;2007年06期

7 趙勇;;龜鹿羊骨湯治療腎陽虛型絕經(jīng)后骨質(zhì)疏松癥臨床研究[J];中醫(yī)學(xué)報;2014年03期

8 潘秉余;張紅紅;;鹿茸生精丸治療腎陽虛型少精子癥100例[J];河北中醫(yī);2007年06期

9 洪文;曾睿;陳澤林;陸強(qiáng)益;盧飛獻(xiàn);唐俊良;江麗瑩;;針?biāo)幗Y(jié)合治療腎陽虛型男性不育癥臨床研究[J];中醫(yī)學(xué)報;2012年02期

10 么曉霞,賈秀榮;心身并治腎陽虛型支氣管哮喘[J];中國煤炭工業(yè)醫(yī)學(xué)雜志;2003年10期

相關(guān)會議論文 前2條

1 夏炳江;童培建;肖魯偉;單樂天;謝健;周羅瑜;金紅婷;;大鼠激素性股骨頭壞死腎陽虛型病證結(jié)合模型構(gòu)建與評價的實(shí)驗(yàn)研究[A];2012·中國醫(yī)師協(xié)會中西醫(yī)結(jié)合醫(yī)師大會第三次會議論文集[C];2012年

2 季久華;季科夫;;仙靈透骨湯熏浴治療腎陽虛型陽痿126例[A];中華中醫(yī)藥學(xué)會第十屆男科學(xué)術(shù)大會論文集[C];2010年

相關(guān)博士學(xué)位論文 前2條

1 冼紹祥;腎陽虛型心力衰竭與神經(jīng)內(nèi)分泌—細(xì)胞因子關(guān)系的研究[D];廣州中醫(yī)藥大學(xué);2005年

2 杜懿杰;若干同證疾�。ò榛虿话橐钟簦┎糠盅装Y及HPA軸相關(guān)指標(biāo)的對照研究[D];復(fù)旦大學(xué);2012年

相關(guān)碩士學(xué)位論文 前10條

1 李藝敏;溫腎堅(jiān)骨方治療老年性骨質(zhì)疏松癥腎陽虛型臨床研究[D];福建中醫(yī)藥大學(xué);2015年

2 丁磊;針?biāo)幝?lián)合治療腎陽虛型神經(jīng)源性膀胱（逼尿肌無力）的臨床效果研究[D];北京中醫(yī)藥大學(xué);2016年

3 郭宇丹;李坤寅教授治療腎陽虛型PCOS的經(jīng)驗(yàn)總結(jié)[D];廣州中醫(yī)藥大學(xué);2016年

4 位路其;助孕湯治療腎陽虛型PCOS致不孕癥的臨床觀察[D];河南中醫(yī)藥大學(xué);2016年

5 劉李娜;中西醫(yī)結(jié)合治療腎陽虛型排卵障礙性不孕癥合并甲減的臨床研究[D];山東中醫(yī)藥大學(xué);2015年

6 王洪雷;右歸飲加減治療老年性骨質(zhì)疏松癥（腎陽虛型）的臨床研究[D];長春中醫(yī)藥大學(xué);2010年

7 趙洋;隔藥灸臍治療腎陽虛型腰椎間盤突出癥的臨床觀察[D];山東中醫(yī)藥大學(xué);2015年

8 任飛;巴戟天寡糖膠囊治療腎陽虛型輕中度抑郁癥臨床研究[D];山西中醫(yī)學(xué)院;2015年

9 李建平;二歸補(bǔ)腎方治療腎陽虛型慢性再生障礙性貧血的臨床研究[D];湖南中醫(yī)學(xué)院;2004年

10 杜志斌;“金水相生”法對腎陽虛型排卵障礙性不孕的影響[D];貴陽中醫(yī)學(xué)院;2014年

，

本文編號：1886992