本文選題：慢性腎炎 + 辨證論治　； 參考：《南京中醫(yī)藥大學》2017年碩士論文

【摘要】：慢性腎小球腎炎屬于臨床常見疾病,多發(fā)于人群中,病情隱匿不易發(fā)現(xiàn),是我國引起慢性腎衰竭的主要病因。中醫(yī)藥在治療此疾病取得一定程度療效,但具體治療及用藥方法并未有統(tǒng)一的方案,因此對于療效存在著較大程度的差異。研究目的:在中醫(yī)基礎理論指導下,以辨證論治為原則,比較中醫(yī)辨證論治(湯劑)與協(xié)定方對慢性腎小球腎炎的治療效果。分別用辨證論治及協(xié)定方治療慢性腎小球腎炎,比較兩者經(jīng)治療前后的臨床療效差異,以評估療效的優(yōu)劣,進一步提升慢性腎小球腎炎在中醫(yī)治療方面的診法方藥的選擇。研究方法:選取符合慢性腎小球腎炎診斷及納入標準的60例患者,將其隨機分為辨證論治組、協(xié)定方組兩組,各30例。試驗由江蘇省中醫(yī)院進行研究,比較辨證論治與協(xié)定方的臨床療效,及研究安全性。選擇60例年齡在1 4-7 0歲,就診于江蘇省中醫(yī)院腎內(nèi)科門診及病房,符合慢性皆小球腎炎西醫(yī)診斷標準和中醫(yī)診斷標準的患者為受試人群,所有病例辨證均由導師1人完成。A組采用辨證論治+對癥治療+一般治療,B組采用(健腎片+血塞通軟膠囊)+對癥治療+一般治療,兩組患者均治療3個月,觀察兩組治療前后臨床癥狀、尿常規(guī)、腎功能等的變化,比較辯證論治與協(xié)定方的臨床療效及其安全性。研究結果:疾病療效:辨證論治組臨床有效率為89.99%。協(xié)定方組為76.67%。中醫(yī)癥候療效顯示:辨證論治組有效率為86.67%。協(xié)定方組為76.66%。本次試驗過程中兩組病例均沒有出現(xiàn)不良反應和不良事件的記錄,也未發(fā)現(xiàn)與試驗藥物有關的有臨床意義的異常改變。研究結論:經(jīng)過治療前后療效觀察及統(tǒng)計結果看來,中醫(yī)治療60例慢性腎小球腎炎患者均有效,但以辨證論治組療效更為顯著。研究表明,中醫(yī)對慢性腎小球腎炎治療效果肯定,但仍然需要提倡以辨證施治為原則。
[Abstract]:Chronic glomerulonephritis is a common clinical disease. Traditional Chinese medicine has achieved a certain degree of efficacy in the treatment of this disease, but the specific treatment and drug use methods do not have a unified plan, so there is a greater degree of difference in the efficacy. Objective: to compare the therapeutic effect of traditional Chinese medicine (TCM) and traditional Chinese medicine (TCM) on chronic glomerulonephritis under the guidance of TCM basic theory and the principle of syndrome differentiation and treatment. The treatment of chronic glomerulonephritis was treated by differentiation of symptoms and signs, and the difference of clinical efficacy before and after treatment was compared, in order to evaluate the advantages and disadvantages of the curative effect and to further enhance the choice of traditional Chinese medicine in the treatment of chronic glomerulonephritis. Methods: 60 patients with chronic glomerulonephritis were randomly divided into two groups: syndrome differentiation group (n = 30) and agreement group (n = 30). The study was carried out by Jiangsu Provincial Hospital of traditional Chinese Medicine to compare the clinical efficacy and safety of treatment based on syndrome differentiation and agreement. Sixty patients, aged from 14 to 70 years, who were admitted to the Department of Renal Medicine of Jiangsu Provincial traditional Chinese Medicine Hospital and met the diagnostic criteria of western medicine and traditional Chinese medicine for chronic glomerular glomerulonephritis were selected as the subjects. All cases were treated with syndrome differentiation by one tutor. Group A was treated with syndrome differentiation and general treatment. Group B was treated with "Jianshen tablet Xuesaitong soft capsule". The patients in both groups were treated for 3 months. The changes of clinical symptoms, urine routine and renal function before and after treatment were observed, and the clinical efficacy and safety of dialectical and conventional treatment were compared. Results: the curative effect of disease: the clinical effective rate of syndrome differentiation group was 89.9999. The number of parties to the agreement is 76.67. The curative effect of TCM syndrome showed that the effective rate of syndrome differentiation group was 86.67. The number of parties to the agreement is 76.66. No adverse reactions and adverse events were recorded in both groups, and no significant clinical changes related to the drugs were found in the two groups. Conclusion: after observation of curative effect before and after treatment and statistical results it can be seen that 60 cases of chronic glomerulonephritis treated by traditional Chinese medicine are effective but the curative effect of treatment group based on differentiation of symptoms and signs is more remarkable. The research shows that TCM is effective in treating chronic glomerulonephritis, but the principle of syndrome differentiation should be advocated.
【學位授予單位】：南京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R277.5

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