發(fā)布時(shí)間：2018-05-11 18:04

  本文選題：莊國康教授 + 重潛搜風(fēng)法�。� 參考：《中國中醫(yī)科學(xué)院》2016年博士論文

【摘要】：一、中醫(yī)理論的博大精深,跟師三年余來,系統(tǒng)繼承和總結(jié)了莊國康教授的學(xué)術(shù)思想：1莊國康教授的辨證特點(diǎn)：審疹論治。皮膚病的特點(diǎn)就在于其可見性與特異性,即皮膚病病變在于肌表,可用肉眼直接觀察,且每種皮膚病都有其獨(dú)特的表現(xiàn)和特點(diǎn),“有諸內(nèi)必形于外”,皮膚病明顯的外在表現(xiàn)反應(yīng)了機(jī)體內(nèi)部的正邪變化,在漫長的時(shí)間里,經(jīng)過歷代外科醫(yī)家們不斷的摸索、總結(jié),發(fā)展出了一條有別于內(nèi)科“望聞問切”四診合參的診斷模式,即以皮損的不同表現(xiàn)、特點(diǎn)為主、以舌苔脈象為輔,來進(jìn)行辨病辨證、分型論治。因此,審疹論治是中醫(yī)皮膚病學(xué)的特色思想。莊國康教授師承閻效然、朱仁康、段馥亭等名家,深刻的領(lǐng)會(huì)了審疹論治的思想并將之貫徹于臨床。2莊國康教授的立法特點(diǎn)：法法結(jié)合。莊國康教授臨床治療皮膚病確立了很多的治療法則：(1)疏風(fēng)清熱法(2)養(yǎng)血潤燥、消風(fēng)止癢法(3)健脾除濕法(4)清利濕熱法(5)芳香化濕法(6)活血清熱法(7)涼血活血法(涼血活血止血法)(8)滋陰活血法(9)養(yǎng)血活血法(10)活血通絡(luò)軟堅(jiān)散結(jié)法(11)溫經(jīng)活血法(12)涼血清營法(13)重鎮(zhèn)搜風(fēng)法(14)酸收固表法(15)滋腎抑火法(16)溫陽補(bǔ)腎法(17)玄府開竅法等。莊國康教授臨診時(shí),常抓住患者病證病情主要矛盾,辨證論治,確定相應(yīng)的治療法則,并靈活配伍,取得好的療效。比如同樣是頑固性瘙癢皮膚病,莊國康教授會(huì)抓住主要矛盾頑固性瘙癢確立重潛搜風(fēng)的治則,但是要提高重潛搜風(fēng)藥物的療效,其配伍的靈活運(yùn)用至關(guān)重要。在治療頑固性瘙癢皮膚病時(shí),需根據(jù)皮疹顏色、形態(tài)、整體辨證論治,如養(yǎng)血者配伍當(dāng)歸,熟地黃；潤燥者配伍生地、玄參、制何首烏；活血者配伍丹參、降香、當(dāng)歸、川芎、茜草、三棱、莪術(shù)；滋陰者配伍天冬、麥冬、石斛、黃精：涼血者配伍生地、牡丹皮、紫草、生槐花；化痰者配伍萊菔子、白芥子、海浮石、海蛤殼；健脾利濕者配伍陳皮、半夏、茯苓、甘草；舒肝解郁者配伍香附、柴胡、郁金；清熱者配伍白茅根、白花蛇舌草、大青葉；發(fā)于四肢者,常加雞血藤、首烏藤。3莊國康教授的方藥特點(diǎn)：(1)經(jīng)驗(yàn)用藥：涼血：羚羊角,玳瑁、生地、牡丹皮；紫草、生槐花、白茅根；活血：丹參、降香、當(dāng)歸、川芎、茜草,三棱、莪術(shù)；養(yǎng)血：當(dāng)歸、熟地黃、首烏；益氣：黃精、太子參、黃芪；滋陰：生地黃、玄參、天冬、麥冬、玉竹、石斛：瀉火：生石膏、梔子；燥濕：黃連、黃芩、黃柏、苦參；除濕：平胃散(陳皮、厚樸、蒼術(shù)、甘草)：化痰：萊菔子、白芥子、海浮石、海蛤殼；散結(jié)：土貝母、瓜蔞、海藻、昆布、生牡蠣；通絡(luò)：雞血藤、鉤藤、伸筋草、千年��；涼血清營：生地、丹皮、赤芍、生石膏、知母、玄參、淡竹葉、銀花、滑石粉；清熱解毒：銀花、菊花、苦地丁、蒲公英,土茯苓、白花蛇舌草、大青葉；斂汗固表：麻黃根、生牡蠣、烏梅、五味子、黃芪、防風(fēng)、白術(shù)；重潛：煅磁石、煅赭石、生龍骨、生牡蠣、珍珠母、石決明、紫貝齒；祛風(fēng)：荊芥、防風(fēng)、炒蒺藜；疏風(fēng)清熱：羌活、荊芥、防風(fēng)、白芷、牛蒡子、黃芩。(2)結(jié)合中西醫(yī)理論：莊國康教授幾十年來在中西醫(yī)結(jié)合思路指導(dǎo)下,對(duì)皮膚病的治療用藥方面,做了廣泛、深入的探討,積累了相當(dāng)可貴的臨床經(jīng)驗(yàn),在臨床辨癥、辨證治療基礎(chǔ)上,結(jié)合了疾病病機(jī)特點(diǎn)及中藥本身的性味功用,應(yīng)用藥理研究成果,針對(duì)性的選擇對(duì)疾病的客觀指標(biāo)、病理改變等有明確治療作用的中藥。其中常用的有紅斑鱗屑性——抗腫瘤中藥：白英、蛇莓、龍葵、白花蛇舌草、北豆根、半枝蓮、半邊蓮；紅腫熱痛性——抗感染中藥：馬齒莧、敗醬草、紫草、大青葉、板藍(lán)根、木賊、香附、金銀花；真菌性皮膚病——抗真菌中藥：肉桂、黃精、丁香、藿香、佩蘭、木香、白礬、冰片、五倍子；光化學(xué)治療——增加光敏作用的中藥：白芷、補(bǔ)骨脂、獨(dú)活、虎杖、蒼術(shù)等。(3)經(jīng)驗(yàn)方：重鎮(zhèn)湯、滋陰除濕湯、玄府開竅、涼血活血湯、涼血消風(fēng)散、涼血消風(fēng)散、芳香化濕湯、活血清熱湯、酸收固表湯等。4治療皮膚科常見病的經(jīng)驗(yàn)：(1)治療濕疹,首當(dāng)滋陰除濕；(2)治療銀屑病的一些經(jīng)驗(yàn)：涼血解毒、涼血活血、滋陰活血法；玄府開竅,適當(dāng)配伍一些抗腫瘤中藥。(3)頑固性瘙癢性皮膚病——重潛搜風(fēng)。理論：頑固性瘙癢多伴有情志的改變：心神失養(yǎng),肝失疏泄——治以平肝風(fēng)、寧心神；心主火,火性上炎——治以重潛清熱；核心處方：煅磁石、煅赭石、生龍骨、生牡蠣、珍珠母、石決明、紫貝齒各30g(凡應(yīng)用其中5個(gè)及以上藥物的均視為核心處方)。(3)運(yùn)用“以色補(bǔ)色法”治療色素病如白癜風(fēng)：黑芝麻,雄黑豆,桑葚,何首烏,熟地黃,肉蓯蓉等；黃褐斑：白術(shù)、白茯苓、白芷,白扁豆,白芍,白芨,白僵蠶,白前,白芥子,白蘞,白英,白附子等。5莊國康教授常用治法及方藥心得：除濕法中有滋陰除濕法、健脾除濕法、清利濕熱法、芳香化濕法、溫陽化濕法等,涼血法中有涼血活血法、涼血清營法、涼血止血法等,活血化瘀法中有活血清熱法、涼血活血法、滋陰活血法、養(yǎng)血活血法、活血通絡(luò),軟堅(jiān)散結(jié)法、溫經(jīng)活血法等,清熱法中有清熱解毒法、疏風(fēng)清熱法、清肺降火、瀉胃除熱等,其他內(nèi)治法還有重潛搜風(fēng)法、玄府開竅法、養(yǎng)血潤燥、消風(fēng)止癢、酸收固表法、滋腎抑火法、溫補(bǔ)肝腎法等,外治法主要有增白明目、增白止癢、涼血清熱、燥濕殺蟲、活血化瘀、清熱斂濕等。莊國康教授在各具體的治法下有對(duì)應(yīng)的習(xí)慣用藥及經(jīng)驗(yàn)用藥。6莊國康教授治療皮膚瘙癢的經(jīng)驗(yàn)：莊國康教授在臨診時(shí),采用理法方藥的思維模式,條理清晰,認(rèn)為立法準(zhǔn)確是提高臨床療效的前提,而立法的依據(jù)是辨證恰當(dāng),辨證就是辨疾病的病因病機(jī)。瘙癢的病因病機(jī)復(fù)雜,難以一證蔽之,既有內(nèi)因,亦有外因。辨明瘙癢病因病機(jī)后,莊國康教授針對(duì)具體病因的確立治法,其中注重治法的配伍應(yīng)用,非常靈活,“法法結(jié)合,復(fù)方用藥”,收到了很好的療效。二、臨床研究：系統(tǒng)建立了莊國康教授近10年門診病歷的大數(shù)據(jù)庫,規(guī)范了門診診斷病名。第一次從大數(shù)據(jù)庫中數(shù)據(jù)挖掘重潛搜風(fēng)法治療頑固性瘙癢皮膚病的經(jīng)驗(yàn)及應(yīng)用研究結(jié)果。本數(shù)據(jù)庫共有8820診次,226條診斷。重潛搜風(fēng)法是莊國康教授治療頑固性瘙癢的經(jīng)驗(yàn)治法,經(jīng)長期臨床觀察,療效確切,但傳統(tǒng)的個(gè)案總結(jié)、報(bào)告難以采集齊全許多有用的信息,使經(jīng)驗(yàn)的推廣缺乏大數(shù)據(jù)支持。本研究建立并豐富了莊國康教授經(jīng)驗(yàn)數(shù)據(jù)庫,引入了“循證”思想,強(qiáng)化了“證據(jù)”概念,形成一系列數(shù)據(jù)分析挖掘方法,人機(jī)結(jié)合,以人為主,總結(jié)莊國康教授經(jīng)驗(yàn),不僅可發(fā)現(xiàn)莊國康教授應(yīng)用重潛搜風(fēng)法治療頑固性瘙癢皮膚病總體診療特點(diǎn),也能為后續(xù)深層次的挖掘分析提供工作基礎(chǔ),保證了本研究獲得高級(jí)別證據(jù)及成果的真實(shí)性、可靠性,可實(shí)現(xiàn)經(jīng)驗(yàn)的可重復(fù)性及穩(wěn)定性。三、繼承與發(fā)展：1、溫陽法在皮科的應(yīng)用：在跟師過程中,受莊國康教授玄府開竅法運(yùn)用的啟發(fā),臨床處方在運(yùn)用莊國康教授經(jīng)驗(yàn)時(shí),辨證佐以附子等溫陽藥,取得了較好的療效。皮膚病,顧名思義,是發(fā)于身體最外層的皮膚,頭而亦多見。皮疹特點(diǎn)表現(xiàn)紅、腫、熱、癢居多。單純皮疹辨證為熱、火,治以清熱解毒涼血藥,如果患者本身為陽虛體質(zhì),皮疹表現(xiàn)實(shí)質(zhì)是虛火上炎或虛火外越,也許短期內(nèi)會(huì)收到效果,但從長期療效來看,更多的是久治不愈甚或越治越差,從而失治、誤治,所以皮膚科疾病中,如痤瘡,尤其是囊腫性痤瘡、穿鑿性毛囊炎,在化痰散結(jié)的基礎(chǔ)上,辨證佐以附子潛陽、溫陽,往往能收到意想不到的效果。2、進(jìn)一步按照GCP規(guī)范進(jìn)行隨機(jī)、對(duì)照研究,客觀驗(yàn)證了朱仁康、莊國康教授治療手足癬的經(jīng)驗(yàn)療效。上世紀(jì)七十年代,莊國康、許銑教授在我國著名中醫(yī)皮外科專家朱仁康名老中醫(yī)治療手足癬的有效經(jīng)驗(yàn)方——醋泡方(主要藥物組成：荊芥18g,防風(fēng)18g,紅花18g,地骨皮18g,皂角刺30g,大楓子30g,明礬18g等)基礎(chǔ)上開發(fā)研究了改良醋泡方(即現(xiàn)在院內(nèi)制劑醋泡方),即將上方藥物按比例搗碎,醋酸浸泡后滲濾出浸液,加入苯甲酸制備而成；并使用“改良醋泡方治療手足癬”進(jìn)行了臨床觀察總結(jié),真菌抑制試驗(yàn)及掃描電鏡的觀察等系統(tǒng)研究工作,證實(shí)醋泡方有殺菌、抑菌作用,治療角化型手足癬的近期及遠(yuǎn)期效果均佳,但因未按照GCP規(guī)范,未與現(xiàn)代醫(yī)學(xué)認(rèn)可的外用抗真菌藥物進(jìn)行嚴(yán)格的臨床觀察對(duì)照,醋泡方治療角化型手足癬的療效及安全性難以得到國內(nèi)、國際同行認(rèn)可。跟師三年來,完成了所級(jí)課題——醋泡方(即原改良醋泡方)治療角化型手足癬的臨床療效研究：采用陽性藥物平行對(duì)照、隨機(jī)臨床試驗(yàn)設(shè)計(jì)方法,評(píng)價(jià)了醋泡方治療血虛風(fēng)燥證角化型手足癬的臨床療效及其安全性,并進(jìn)一步研究該藥物對(duì)角化型手足癬皮損單項(xiàng)癥狀(包括部位、面積、紅斑、丘疹、角化、皸裂、脫屑、瘙癢、疼痛)的作用。我們抽取了我科門診年齡在18～65歲角化型手足癬患者142例,隨機(jī)分為2組,分別采用“醋泡方”、1%鹽酸特比萘芬乳膏治療后,每周臨床觀察1次,療程結(jié)束后進(jìn)行療效判定及數(shù)據(jù)統(tǒng)計(jì)學(xué)分析。結(jié)果顯示醋泡方治療角化型手足癬的總有效率(96.49%)明顯優(yōu)于對(duì)照組(85.46%)(P0.05),而在改善皮損單項(xiàng)癥狀方面,醋泡方能更好地改善手足癬病的丘疹、角化、鱗屑和瘙癢癥狀。
[Abstract]:First, the theory of traditional Chinese medicine is extensive and profound. After more than three years with the teacher, the academic ideas of Professor Zhuang Guokang are systematically inherited and summarized. The characteristics of the syndrome differentiation of 1 Zhuang Kang Kang: the characteristic of the skin disease is its visibility and specificity, that is, the dermatosis lies in the muscle surface, can be observed directly by the naked eye, and each skin disease has its unique characteristics. The manifestations and characteristics, "there must be in shape in the outside", the apparent external manifestations of skin diseases reflect the internal and positive changes in the body. In the long period of time, through the continuous exploration of the surgeons in the past dynasties, a diagnostic model is developed, which is different from the four diagnosis of the internal medicine, that is, the different manifestations of the skin lesions, and the characteristics of the diagnosis. The Lord, taking the pulse of tongue coating as a supplement, carries out differentiation of syndrome differentiation and classification and treatment. Therefore, the trial of rash is the characteristic thought of the Chinese medicine dermatology. Zhuang Guokang, Shi Chengyan, and Zhu Renkang, Duan Fu ting and other famous people, deeply comprehend the thought of trial rash and put it into clinical.2 Zhuang Guo Kang's legislative characteristics: Law and law combination. Zhuang Guokang Clinical treatment of dermataosis has established a number of treatment principles: (1) wind clearing and clearing heat method (2) nourishing blood and moistening dryness, eliminating wind and antipruritic (3) invigorating spleen and removing damp (4) clearing away wet heat method (5) (6) activating blood and clearing heat method (7) cooling blood and activating blood method (8) nourishing blood and blood activating method (9) nourishing blood and activating blood method (10) activating blood circulation collaterals soft hard loose knot method (11) warm meridian Blood activating method (12) cold blood clearing camp method (13) heavy town search wind method (14) acid collecting and fixing table method (15) nourishing kidney and suppressing fire (16) warming Yang kidney method (17) to open the orifices of Xuan Fu (17). When Professor Zhuang Guo Kang is in the clinic, he often seize the main contradiction of the patient's disease syndrome, make a dialectical treatment, determine the corresponding treatment rule, and get good curative effect. For example, it is also obstinate itching. Skin disease, Professor Zhuang Guokang will seize the main contradiction of stubborn itching to establish the treatment of heavy submersible search wind, but to improve the curative effect of heavy submersible search wind drugs, the flexible use of its compatibility is essential. In the treatment of stubborn pruritus skin disease, it should be based on the skin rash color, form, the whole syndrome differentiation, such as the combination of Chinese angelica, cooked ground yellow; moistening dryness. People with the combination of raw land, Radix Sophorae, and Polygonum multiflorum; the living blood is compatible with Salvia miltiorrhiza, anoda, angelica, Ligusticum chuanxiong, Rhizoma rhizome, zedoary and zedoary; it is compatible with the winter, Ophiopogon, Dendrobium, and yellow semen, the peony skin, the purple grass and the Sophora japonica; the phlegm people with wood foramen, the white mustard, the sea float stone and the sea clam shell; Glycyrrhiza uralensis (licorice); soothing liver depressive in combination with Xiang Fu, bupleurum, tulip; heat clearing people with white mauru root, white flower Hedyotis, and leaf; often added to the extremities, often adding chicken blood VAT, Professor Wu Kun.3 Zhuang Guo Kang: (1) herbal medicine: cold blood: antelope horn, tortoise shell, peony skin; purple grass, Sophora japonica, root; blood activating: Salvia miltiorrhiza, antifragrance, Angelica, Ligusticum chuanxiong, alizara, three prism, zedoary turmeric; nourishing blood: Angelica, radix rehmanniae, Radix Polygoni multiflorum; yhuangjing, Radix Astragalus, Astragalus membranaceus; Radix Astragalus, Radix Ophiopogon, Radix Ophiopogon, Dendrobium: raw gypsum, Fructus Gardenia: Huanglian, Radix Scutellariae, Radix Sophorae, Sophora flavescens; dehumidification: Ping stomach powder (citrus peel, Magnolia officinalis, CAC, licorice): phlegm: Raphani, Raphani, semen Raphani, White mustard, pumice, clam shell; scattered: Fritillaria, Trichosanthes, kelp, Kun cloth, raw oysters; collaterals: Cynthia Coriolis, runchus rimonifolia, stretch weeds, komoeqing camps: raw land, peony root, red peony root, gypsum, Anemarrhena, light bamboo leaves, silverflower, talcum powder; clearing heat and detoxification: silver flower, chrysanthemum, dandelion, dandelion, tuckahoe, tuckahoe, tuckahoe, Hedyotis davidae, big Green leaf; collect sweat and fixed table: ephedra root, oyster, black plum, Schisandra, Radix Astragali, anti wind, Atractylodes; calcined magnets, calcined ochre, raw oysters, raw oyster, mother of pearl, stone cassia, pericentine; dispel wind: mustard, wind control, Tribulus tribulus; thinning wind, mustard, Radix Angelicae, Angelica dahurica, burdock seed, Scutellaria. (2) combined Chinese and Western medicine theory: Zhuang Guo Kang Education Under the guidance of the combination of traditional Chinese and Western medicine for decades, we have made extensive and in-depth discussion on the treatment of skin diseases, and accumulated considerable valuable clinical experience. On the basis of clinical discrimination, syndrome differentiation and treatment, combined with the characteristics of disease pathogenesis and the use of sexual flavor of traditional Chinese medicine, the results of pharmacological research are applied, and the targeted selection of the disease is on the disease. Objective indicators, pathological changes and other traditional Chinese medicine. Among them, the commonly used erythematous scales - antitumor Chinese medicine: white English, snake rberry, dragon anemone, white flower Hedyotis, North bean root, Scutellaria, and half lotus; red and swollen heat pain - anti infective Chinese medicine: Purslane, Patrinia, Herba, latitum, Radix Isatidis, thicchins, periclum, honeysuckle Fungous dermatosis - antifungal Chinese medicine: Cinnamon, yellow essence, clove, huoxifang, Perrin, wood aroma, alum, borneol, gallnut; photochemical therapy: Radix Angelicae dahuricae, psoralen, single live, Polygonum cuspidatum, Cang Atractylodes, etc. (3) experienced prescription: heavy Town soup, Yin Fu dehumidification soup, Xuan Xue Huo Xue soup, cool blood Xiao Feng Feng powder, cool blood Xiaofeng powder, aromatic wet soup, blood activating and clearing soup, acid collection soup and other.4 treatment experience in Department of Dermatology: (1) treatment of eczema, first when nourishing yin and dehumidification; (2) some experience in the treatment of psoriasis: cool blood and detoxification, cool blood and blood circulation, nourishing yin and activating blood method, Xuan Fu opening, suitable for combination with some anti tumor Chinese medicine. (3) stubborn pruritus dermatosis - (3) Heavy submersible search wind. Theory: obstinate itching with more emotional changes: heart loss, liver loss relief - treatment with liver wind, Ningxin, heart fire, fire inflammation - treatment with heavy submersible and heat; the core prescription: Calcined magnets, calcined ochre, raw oysters, mother of oyster, stone cassia, 30g (3) (3) the use of "color supplement" to treat pigmentary diseases such as vitiligo: black sesame, male black bean, mulberry, Radix Polygoni multiflorum, Radix Cistanche, Cistanche and so on; chloasma: Atractylodes, white Poria, Radix Angelicae dahuricae, white Radix Paeoniae, Bletilla Bletilla, white Bombyx, white mustard, white mustard, white British, white aconite and so on. In addition to wet method, there are nourishing yin and removing wet method, invigorating spleen and wet method, clearing wet heat method, aromatization wet method, warming Yang chemical method and so on. There are cold blood and blood activating method, cool blood clearing camp method, cold blood stasis method and so on. In the method of activating blood and removing blood stasis, there are activating blood and clearing heat method, cooling blood and activating blood method, nourishing yin and living blood method, nourishing blood and activating blood method, activating blood circulation and collaterals, soft hard and loose knot method, warming through blood circulation method Methods such as law, heat clearing and detoxification, clearing and clearing heat, clearing fire to reduce fire and removing heat from stomach, other internal treatment methods, including heavy submersion and search wind, mystery house opening and resuscitation, nourishing blood and moistening dryness, eliminating wind and Antipruritus, acid collecting and fixing table, nourishing kidney and inhibiting fire, nourishing liver and kidney, etc., external treatment mainly include whitening and clearing the eyes, increasing whitening and itching, cooling blood and clearing heat, drying wet and removing insect pests, activating blood circulation and removing stasis, Qing Dynasty Professor Zhuang Guo Kang has the experience of treating skin pruritus by Professor Zhuang Guo Kang under the specific treatment methods: Professor Zhuang Guokang's experience in treating skin pruritus: Professor Zhuang Guokang used the thinking mode of theory and prescription in the treatment of medical treatment. It is clear that the legislative accuracy is the premise to improve the clinical efficacy, and the basis of the legislation is to differentiate and identify the appropriate and appropriate differentiation. Syndrome is the etiology and pathogenesis of the disease. The etiology and pathogenesis of itching is complicated, it is difficult to identify the cause of the disease. It has both internal and external causes. After identifying the pathogenesis of pruritus, Professor Zhuang Guokang focused on the treatment of specific causes, which paid attention to the compatibility and Application of the treatment. It was very flexible, "combination of law and compound medicine", and received good curative effect. Two, clinical treatment. Research: the system established a large database of Professor Zhuang Guokang's outpatient medical records for nearly 10 years, standardized the outpatient diagnosis name. The first time from the large database data mining heavy submersible search wind method for the treatment of refractory pruritus skin disease and its application research results. This database has 8820 diagnosis and 226 diagnosis. The heavy submarine search wind method is Professor Zhuang Guokang treatment. The experience of stubborn pruritus, after long-term clinical observation, has a definite curative effect, but it is difficult to collect many useful information from the traditional case summary, which makes the popularization of experience lack large data support. This study has established and enriched the experience database of Professor Zhuang Guokang, introduced the "evidence-based" idea and strengthened the concept of "evidence". A series of data analysis and mining methods, the combination of human-computer and human beings, and a summary of Professor Zhuang Guokang's experience, can not only discover the general diagnosis and treatment characteristics of Professor Zhuang Guokang's application of heavy submersible search wind to treat refractory itchy skin diseases, but also provide a basis for the further analysis of further deep mining and guarantee the high level of evidence and achievements in this study. Authenticity, reliability, can realize the repeatability and stability of experience. Three, inheritance and development: 1, the application of Wen Yang method in dermatology: in the course of following the teacher, enlightened by the application of Zhuang Guokang, Professor Xuan Fu, the clinical prescription, when using professor Zhuang Guokang's experience, has achieved good curative effect. As the name suggests, it is the outermost skin of the body. The skin rash features red, swollen, hot, and itching. The skin rash is heat, heat, and antipyretic and cool blood medicine. If the patient itself is a yang deficiency constitution, the skin rash is in essence is an asthenia fire or an empty fire, and may receive effect in the short term, but from a long term effect, In the Department of Dermatology diseases, such as acne, especially cystic acne, and penetrating folliculitis, on the basis of phlegm and phlegm, the syndrome differentiation with Aconitum latent Yang, Wen Yang, often can receive the unexpected effect of.2, further according to the GCP standard, the random, objective and objective study, objective study, objective To verify the therapeutic effect of Professor Zhu Renkang and Professor Zhuang Guokang on the treatment of tinea hand and foot ringworm. In 70s, Zhuang Guo Kang, Professor Xu Milu, an effective prescription for the treatment of tinea pedis, Zhu Renkang, famous Chinese medicine specialist in Chinese medicine, Zhu Renkang, the main drugs: the main drugs: the main drugs: the main drugs: 18G, 18G, 18G, 18G, 30g, and maple On the basis of sub30g, alum 18G and so on, we developed and studied the modified vinegar bubble square (that is, the present prescription of vinegar bubble in hospital preparation), and then mashed the drugs in proportion to the above, and then percolate the soaked liquid after the acetic acid soaking, and add benzoic acid to prepare it. And the clinical observation, fungal inhibition test and scanning electron microscope view of the treatment of tinea pedis with "modified vinegar bubble recipe" was used. It proved that the vinegar bubble has bactericidal and bacteriostasis effect, and the effect of treating keratosis type of tinea pedis and tinea pedis is good in the near and long term. However, the efficacy and safety of vinegar bubble prescription in the treatment of keratinized and tinea pedis are difficult to get at home because it is not in accordance with the standard of GCP and not strictly observed with the external use antifungal drugs approved by modern medicine. In the past three years, we have completed the clinical efficacy of the "vinegar bubble" prescription in the treatment of keratosis and tinea pedis. The clinical efficacy and safety of vinegar bubble prescription in the treatment of keratosis of blood deficiency and wind dryness were evaluated by using the positive drug parallel control and the design method of the randomized clinical trial. One step was to study the effect of the drug on the unilateral symptoms of keratosis type of tinea pedis (including site, area, erythema, papule, keratosis, chap, desquamation, pruritus, pain). We selected 142 cases of 18~65 year old keratosis patients in our department, randomly divided into 2 groups, respectively, using "vinegar bubble square" and 1% terbinafine hydrochloride cream for treatment, respectively. 1 times a week, the curative effect was determined and the data were analyzed. The results showed that the total effective rate (96.49%) was significantly better than the control group (85.46%) (P0.05). The vinegar bubble could improve the papules, keratinization, scaly and pruritus of the psoriasis in the skin lesions. Shape.

【學(xué)位授予單位】：中國中醫(yī)科學(xué)院
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2016
【分類號(hào)】：R249;R275.9

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本文編號(hào)：1875001