本文選題：高尿酸血癥 + 葵花盤粉�。� 參考：《吉林大學(xué)》2017年碩士論文

【摘要】：[目的]從中西醫(yī)兩個(gè)不同的角度詳述高尿酸血癥的病因病機(jī)、治療進(jìn)展、以及于其他疾病的關(guān)系。觀察葵花盤粉治療高尿酸血癥的臨床療效,評(píng)價(jià)葵花盤粉臨床安全指標(biāo),為高尿酸血癥患者給予一種新的用藥選擇。[資料與方法]收集2015年10月-2016年10月期間符合標(biāo)準(zhǔn)的高尿酸血癥患者70例,隨機(jī)分配成兩組。觀察組35例,男31例,女4例,平均年齡40.03±11.70歲。觀察組高尿酸血癥伴高血壓病4例,伴冠心病者5例,伴糖尿病者7例,伴貧血者1例,伴腦梗塞3例,伴腎臟疾病2例。對(duì)照組35例,男28例,女7例,平均年齡43.09±12.32歲。對(duì)照組高尿酸血癥患者伴高血壓病8例,伴冠心病者8例,伴糖尿病者8例,伴哮喘者1例,伴腦梗塞3例,伴腎臟疾病者1例。觀察組給予中草藥葵花盤粉顆粒制劑,每日1次,每次服用10g,飯后服用,1個(gè)月1療程。對(duì)照組給予別嘌醇片0.1 g,每日2次,1個(gè)月為1個(gè)療程。1月后觀察治療前后兩組SUA、BUN、Cr、ALT、AST指標(biāo)的變化情況。[結(jié)果]通過對(duì)觀察組及對(duì)照組的統(tǒng)計(jì)分析,兩組的性別、年齡、臨床檢驗(yàn)值無顯著性差異,具有可比性(P0.05)。觀察組臨床顯著有效8例,臨床有效26例,臨床無效1例,有效率為97.14%;對(duì)照組臨床顯著有效0例,臨床有效30例,臨床無效5例,有效率為85.71%。兩組療效經(jīng)秩和檢驗(yàn),z值為-3.201,P(0.001),P0.05,具有統(tǒng)計(jì)學(xué)意義。數(shù)據(jù)分析顯示觀察組療效明顯,對(duì)照組降SUA水平處于下勢(shì)。治療前兩組BUN均值經(jīng)獨(dú)立樣本T檢驗(yàn),P(0.537),P0.05,無統(tǒng)計(jì)學(xué)意義,兩組可以進(jìn)行比較。觀察組BUN經(jīng)過前后治療,選擇配對(duì)T檢驗(yàn)統(tǒng)計(jì)分析,P(0.001),P0.05,說明觀察組BUN指標(biāo)下降顯著,有統(tǒng)計(jì)學(xué)意義。觀察組和對(duì)照組治療后BUN經(jīng)獨(dú)立樣本T檢驗(yàn),P(0.001),P0.05,具有統(tǒng)計(jì)學(xué)意義。兩組治療后,觀察組BUN的均值下降,而對(duì)照組BUN均值上升,說明觀察組的藥物能夠整體降低BUN的水平。治療前兩組Cr均值經(jīng)獨(dú)立樣本T檢驗(yàn),P(0.484),P0.05,無統(tǒng)計(jì)學(xué)意義,兩組可進(jìn)行比較。觀察組Cr經(jīng)過前后治療,選擇配對(duì)樣本T檢驗(yàn)分析,P(0.000),P0.05,說明觀察組Cr指標(biāo)顯著降低,有統(tǒng)計(jì)學(xué)意義。兩組治療后Cr經(jīng)獨(dú)立樣本T檢驗(yàn),P(0.002),P0.05,具有統(tǒng)計(jì)學(xué)意義。兩組治療后,觀察組Cr的均值下降,而對(duì)照組Cr均值上升,說明觀察組的藥物能夠整體降低Cr的水平。治療前兩組AST均值經(jīng)獨(dú)立樣本T檢驗(yàn),P(0.787),P0.05,無統(tǒng)計(jì)學(xué)意義,兩組可進(jìn)行比較。觀察組治療前后AST經(jīng)配對(duì)樣本T檢驗(yàn),P(0.758),P0.05,無統(tǒng)計(jì)學(xué)意義。觀察組和對(duì)照組治療后AST經(jīng)獨(dú)立樣本T檢驗(yàn),P(0.320),P0.05,無統(tǒng)計(jì)學(xué)意義,說明觀察組和對(duì)照對(duì)AST的影響無顯著差異。觀察組治療前后ALT經(jīng)配對(duì)樣本T檢驗(yàn),P(0.057),P0.05,無統(tǒng)計(jì)學(xué)意義。兩組治療后ALT經(jīng)獨(dú)立樣本T檢驗(yàn),P(0.713),P0.05,無統(tǒng)計(jì)學(xué)意義,說明兩組藥物對(duì)ALT的影響無統(tǒng)計(jì)學(xué)意義。[結(jié)論]葵花盤粉通過現(xiàn)代生物酶提取技術(shù),減少內(nèi)生尿酸生成,加速尿酸的排泄,起到降低血尿酸的綜合作用。葵花盤粉能夠減少BUN、Cr的數(shù)值,既能降低血尿酸,同時(shí)又能保護(hù)腎功�？ūP粉對(duì)ALT、AST的指標(biāo)無影響,前后均值下降雖無統(tǒng)計(jì)學(xué)意義,說明對(duì)肝功能影響不大。
[Abstract]:[Objective] to detail the etiology and pathogenesis of hyperuricemia, treatment progress and the relationship between other diseases from two different angles of Chinese and Western medicine. The clinical efficacy of sunflower disc powder in the treatment of hyperuricemia was observed, the clinical safety index of sunflower disc powder was evaluated and a new choice of medication for patients with hyperuricemia was given. [data and methods] collected 2015 In the period of October -2016 October, 70 cases of hyperuricaemia were randomly assigned to two groups. There were 35 cases in the observation group, 31 men and 4 women, with the average age of 40.03 + 11.70 years. There were 4 cases of hyperuricemia with hypertension, 5 patients with coronary heart disease, 7 cases of diabetes with diabetes, 1 cases with anemia, 3 cases of cerebral infarction, 2 cases of renal disease. There were 28 cases of male and 7 women, with an average age of 43.09 + 12.32 years. The control group with hyperuricemia was accompanied by hypertension, 8 cases, 8 cases of coronary heart disease, 8 cases of diabetes, 1 cases of asthma, 3 cases of cerebral infarction and 1 cases of kidney disease. The observation group was given Chinese herbal medicine with sunflower disc powder preparation, once a day, taking 10g every time, after meals, 1 courses for 1 months. The control group was given Allopurinol Tablets 0.1 g, 2 times a day, 1 months for 1 courses of.1 months after observation of two groups of SUA, BUN, Cr, ALT, AST index changes. [results] through the statistical analysis of the observation group and the control group, the two groups of sex, age, clinical test value had no significant difference (P0.05). The observation group was significantly effective in clinical 8. 26 clinical cases were effective, 1 cases were ineffective, the effective rate was 97.14%, the control group was clinically effective 0 cases, clinical effective 30 cases and clinical invalid 5 cases, the effective rate was 85.71%. two group by rank sum test, the Z value was -3.201, P (0.001), P0.05, and the data analysis showed that the observation group had obvious curative effect, and the SUA level in the control group was lower in the lower level. Before treatment, the average BUN of the two groups was tested by independent sample T, P (0.537) and P0.05, without statistical significance. The two groups could be compared. The observation group was treated with BUN before and after, and selected the statistical analysis of paired T test, P (0.001), P0.05, indicating that the BUN index of the observation group decreased significantly and had the significance of overall planning. The BUN of the observation group and the control group were tested by independent samples T test, P (0) .001), P0.05, with statistical significance. After two groups of treatment, the mean value of BUN in the observation group decreased, while the mean value of BUN in the control group increased, indicating that the drugs in the observation group were able to reduce the level of BUN as a whole. The mean Cr value of the group before the treatment was tested by independent sample T test, P (0.484), P0.05, no statistical significance, and the two groups could be compared. The observation group was treated with Cr before and after the treatment, selection. Paired samples T test analysis, P (0), P0.05, indicating that the observation group Cr indicators significantly decreased, statistically significant. Two groups after treatment Cr independent sample T test, P (0.002), P0.05, with statistical significance. After two groups of treatment, the mean of Cr in the observation group decreased, while the control group Cr mean increased, indicating that the drug in the observation group can reduce Cr level. Before and after treatment, the average AST of the two groups was tested by independent sample T, P (0.787) and P0.05 without statistical significance. The two groups could be compared. The observation group was tested by paired samples T test, P (0.758), P0.05, without statistical significance before and after treatment. The observation group and the control group were tested by independent sample T, P (0.320), P0.05, with no statistical significance, indicating the observation group and the control. There was no significant difference in the effect on AST. ALT was tested by paired samples before and after treatment in the observation group, P (0.057), and P0.05 had no statistical significance. The two groups were treated by independent sample T test, P (0.713), P0.05, without statistical significance, indicating that the effect of two groups of drugs on ALT was not statistically significant. [Conclusion] sunflower disc powder was reduced by modern bioenzyme extraction technology. Endophytic uric acid is produced to accelerate uric acid excretion, and it plays a comprehensive role in reducing uric acid. Sunflower disc powder can reduce the value of BUN and Cr, which can not only reduce the blood uric acid, but also protect the renal function. The sunflower disc powder has no effect on the index of ALT and AST, although the mean decrease in the mean time is not statistically significant, indicating that the effect of the liver function is not significant.

【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 繆明星;王星;陸琰;王欣;;芹菜素對(duì)氧嗪酸鉀鹽致高尿酸血癥小鼠的降尿酸及腎保護(hù)作用機(jī)制研究[J];中國藥房;2016年34期

2 喬會(huì)秀;李匯博;;秦絡(luò)化濁方治療高尿酸血癥40例[J];陜西中醫(yī);2016年09期

3 劉小波;薛均來;;一種抗痛風(fēng)中草藥葵花盤粉的藥理作用[J];內(nèi)蒙古中醫(yī)藥;2016年08期

4 曾金祥;許兵兵;王娟;畢瑩;王曉云;鐘國躍;任剛;朱繼孝;李敏;朱玉野;;車前子中毛蕊花糖苷及異毛蕊花糖苷降低急性高尿酸血癥小鼠血尿酸水平及其機(jī)制[J];中成藥;2016年07期

5 黃雨晴;張瑩;莫與京;吳櫻;李捷;陳紀(jì)言;周穎玲;馮穎青;;原發(fā)性老年高血壓患者高尿酸血癥患病率的調(diào)查研究[J];中華老年心腦血管病雜志;2015年05期

6 滕志濤;陳聰;趙培勇;湯金霞;李妍枚;郭志勇;孫鵬;;高尿酸血癥誘導(dǎo)高血壓發(fā)病的實(shí)驗(yàn)研究[J];濱州醫(yī)學(xué)院學(xué)報(bào);2015年02期

7 奉紅梅;;四妙散加味治療無癥狀性高尿酸血癥療效觀察[J];陜西中醫(yī);2015年03期

8 于麗紅;王興臣;劉偉;宗壽健;;試論血濁理論及臨床應(yīng)用[J];中國中醫(yī)藥現(xiàn)代遠(yuǎn)程教育;2015年01期

9 吳堅(jiān);蔣熙;姜丹;高想;朱建華;朱婉華;朱建平;;國醫(yī)大師朱良春高尿酸血癥辨治實(shí)錄及經(jīng)驗(yàn)擷菁[J];江蘇中醫(yī)藥;2014年12期

10 嘉士健;雷行華;廖建坤;;針灸結(jié)合中藥治療高尿酸血癥48例[J];實(shí)用中醫(yī)藥雜志;2014年10期

相關(guān)碩士學(xué)位論文 前1條

1 索金玲;向日葵花盤中有效化學(xué)成分分析及抗氧化性測(cè)定[D];新疆大學(xué);2010年

，

本文編號(hào)：1871315