本文選題：白癜風(fēng) + 散寒活血祛白方　； 參考：《廣西中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察散寒活血祛白方治療寒滯經(jīng)脈證成人白癜風(fēng)患者的療效,及其對(duì)VASI值、補(bǔ)體C3水平及生活質(zhì)量的影響。方法:選取符合納入標(biāo)準(zhǔn)的成人白癜風(fēng)患者80例,選用隨機(jī)數(shù)字表法將其分為觀察組和對(duì)照組各40例,觀察組采用內(nèi)服散寒活血祛白方配合外擦散寒活血祛白酊治療,對(duì)照組采用內(nèi)服白癜風(fēng)膠囊配合外擦散寒活血祛白酊治療,觀察組與對(duì)照組均于治療前及治療3個(gè)月后進(jìn)行VASI值的評(píng)估,補(bǔ)體C3水平的檢測(cè)和DLQI的填寫,以及安全相關(guān)常規(guī)檢查,并對(duì)相關(guān)不良反應(yīng)進(jìn)行及時(shí)記錄。結(jié)果:觀察組與對(duì)照組基線一致。經(jīng)不同方案治療3個(gè)月后,(1)分別對(duì)觀察組和對(duì)照組治療前后的VASI值進(jìn)行統(tǒng)計(jì)分析,兩組均P＜0.05,差異有統(tǒng)計(jì)學(xué)意義,對(duì)治療后兩組VASI值進(jìn)行比較,P＜0.05,有統(tǒng)計(jì)學(xué)意義;兩組患者治療結(jié)束時(shí)療效比較,P＜0.05,差異有統(tǒng)計(jì)學(xué)意義,觀察組有效率為75.68%,對(duì)照組有效率為52.63%,觀察組有效率明顯高于對(duì)照組;(2)分別對(duì)觀察組和對(duì)照組治療前后的補(bǔ)體C3值進(jìn)行統(tǒng)計(jì)分析,兩組均P＜0.05,差異有統(tǒng)計(jì)學(xué)意義,對(duì)治療后兩組補(bǔ)體C3值進(jìn)行比較,P＜0.05,有統(tǒng)計(jì)學(xué)意義;(3)分別對(duì)觀察組和對(duì)照組治療前后的DLQI值進(jìn)行統(tǒng)計(jì)分析,兩組均P＜0.05,差異有統(tǒng)計(jì)學(xué)意義,對(duì)治療后兩組DLQI值進(jìn)行比較,P＜0.05,有統(tǒng)計(jì)學(xué)意義;(4)納入患者對(duì)本試驗(yàn)治療方案耐受性較好,無(wú)藥物相關(guān)嚴(yán)重不良反應(yīng)的發(fā)生。結(jié)論:(1)散寒活血祛白方可減少寒滯經(jīng)脈證成人白癜風(fēng)患者的皮損面積,其臨床療效肯定,治療有效率為75.68%;(2)散寒活血祛白方可提高寒滯經(jīng)脈證成人白癜風(fēng)患者的補(bǔ)體C3水平;(3)散寒活血祛白方可提高寒滯經(jīng)脈證成人白癜風(fēng)患者的生活質(zhì)量。
[Abstract]:Objective: to observe the curative effect of dispelling cold and activating blood circulation and removing white prescription in treating adult vitiligo with cold stagnation and meridian syndrome, and its effect on VASI value, C3 level and quality of life. Methods: 80 adult patients with vitiligo were selected and randomly divided into observation group (n = 40) and control group (n = 40). The patients in the control group were treated with vitiligo capsule combined with external wiping and dissipating cold and activating blood circulation and removing white tincture. The VASI value, complement C3 level and DLQI filling were evaluated before treatment and 3 months after treatment in the observation group and the control group. And safety related routine inspection, and related adverse reactions are recorded in a timely manner. Results: the baseline of the observation group was the same as that of the control group. After 3 months of treatment with different regimens, the VASI values of the observation group and the control group were statistically analyzed before and after treatment. The difference between the two groups was statistically significant (P < 0.05). The VASI values of the two groups were compared after treatment (P < 0.05). There was a significant difference between the two groups at the end of treatment (P < 0.05). The effective rate of observation group was 75.68 and that of control group was 52.63. The effective rate of observation group was significantly higher than that of control group (P < 0.05). After treatment, the complement C3 values of the two groups were compared (P < 0.05, with statistical significance). The DLQI values of the observation group and the control group before and after treatment were statistically analyzed respectively (P < 0.05), and the difference was statistically significant. The DLQI values of the two groups were compared (P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, respectively). Conclusion (1) the prescription of dispersing cold and activating blood circulation and dispelling white can reduce the area of skin lesion in adult patients with vitiligo of cold stagnation meridian syndrome, and its clinical curative effect is positive. The effective rate of treatment was 75.680.The prescription of dispersing cold and activating blood circulation and removing white could improve the level of complement C3 of adult patients with vitiligo of cold stagnation meridian syndrome. The prescription of dispersing cold and activating blood circulation could improve the quality of life of adult patients with vitiligo of cold stagnation meridian syndrome.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R275.9

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