本文選題：功能性消化不良 + 脾胃虛寒型　； 參考：《廣西中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:本研究通過(guò)觀察溫陽(yáng)和胃方對(duì)脾胃虛寒型功能性消化不良的臨床療效、安全性以及對(duì)胃動(dòng)素水平的變化,為中醫(yī)藥治療功能性消化不良提供新的思路和方法。方法:本研究采用隨機(jī)對(duì)照的研究方法,將符合納入標(biāo)準(zhǔn)的功能性消化不良患者82例隨機(jī)分為治療組和對(duì)照組,每組各41例。治療組服用溫陽(yáng)和胃方治療,對(duì)照組服用枸櫞酸莫沙必利片和雷貝拉唑鈉腸溶片治療,兩組療程均為4周。觀察兩組治療前后中醫(yī)癥候、生存質(zhì)量以及胃動(dòng)素水平變化情況。采用SPASS17.0統(tǒng)計(jì)軟件統(tǒng)計(jì)分析。結(jié)果:剔除脫落病例3例,共完成觀察病例79例,其中治療組40例,對(duì)照組39例。1.臨床整體療效比較:治療后,治療組總有效率為92.50%,對(duì)照組總有效率為74.36%,治療組總有效率明顯高于對(duì)照組(P0.05)。2.中醫(yī)癥候積分比較:治療后,治療組各癥狀較治療前均有明顯改善(P0.05);對(duì)照組胃脘疼痛、胃脘脹悶、泛吐清水、食少納呆癥狀較治療前好轉(zhuǎn)(P0.05),其他癥狀未見好轉(zhuǎn);與對(duì)照組比較,治療組除胃脘疼痛、泛吐清水癥狀外,其他癥狀改善均優(yōu)于對(duì)照組(P0.05)。3.FDDQL比較:治療后,治療組在改善日常生活、憂慮、睡眠、不適、健康感覺、壓力方面均明顯優(yōu)于對(duì)照組(P0.05);在改善飲食、疾病控制方面兩組療效相當(dāng)(P0.05)。4.血漿胃動(dòng)素比較:治療后兩組血漿胃動(dòng)素水平均較治療前升高,差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療后組間比較,治療組血漿胃動(dòng)素水平明顯高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。5.復(fù)發(fā)率比較:治療組復(fù)發(fā)率為16.22%,對(duì)照組復(fù)發(fā)率為41.38%,治療組復(fù)發(fā)率明顯低于對(duì)照組(P0.05)。6.安全性指標(biāo):兩組患者在治療期間均未發(fā)生不良反應(yīng)。結(jié)論:1.溫陽(yáng)和胃方治療脾胃虛寒型功能性消化不良的臨床療效確切,能提高患者生存質(zhì)量,且復(fù)發(fā)率低,未發(fā)現(xiàn)不良反應(yīng),安全性好,值得臨床推廣應(yīng)用。2.溫陽(yáng)和胃方治療脾胃虛寒型功能性消化不良的作用機(jī)制可能與胃動(dòng)素水平升高有關(guān)。
[Abstract]:Objective: to observe the clinical efficacy, safety and changes of motilin level of Wenyang Hewei recipe in the treatment of functional dyspepsia with deficiency of spleen and stomach, and to provide a new way of thinking and method for the treatment of functional dyspepsia with traditional Chinese medicine. Methods: 82 patients with functional dyspepsia were randomly divided into treatment group and control group with 41 cases in each group. The treatment group was treated with Wenyang and Wei decoction, the control group was treated with mosapride citrate tablets and rabeprazole enteric coated tablets. The course of treatment in both groups was 4 weeks. The changes of TCM symptoms, quality of life and motilin level before and after treatment were observed. SPASS17.0 statistical software was used for statistical analysis. Results: three cases were excluded and 79 cases were observed, including 40 cases in the treatment group and 39 cases in the control group. Comparison of the overall clinical efficacy: after treatment, the total effective rate of the treatment group was 92.50 and the total effective rate of the control group was 74.36. The total effective rate of the treatment group was significantly higher than that of the control group (P 0.05). Comparison of TCM symptom score: after treatment, the symptoms in the treatment group were significantly improved compared with those before treatment; in the control group, the symptoms of epigastric pain, distention and boredom were significantly improved; in the control group, the symptoms of stomach ache, distension, vomiting and dyspnea were improved compared with those before treatment, but the other symptoms were not improved; compared with the control group, The improvement of other symptoms in the treatment group was better than that in the control group (P 0.05). 3. Comparison of FDDQL: after treatment, the treatment group improved daily life, anxiety, sleep, discomfort and health feeling. Stress was significantly better than that of control group (P 0.05), and the effect of two groups on improving diet and disease control was similar to that of control group (P 0.05). Comparison of plasma motilin: after treatment, the plasma motilin level of the two groups was higher than that before treatment, the difference was statistically significant (P 0.05), and after treatment, the plasma motilin level of the treatment group was significantly higher than that of the control group, and the difference was statistically significant. The recurrence rate of the treatment group was 16.22 and that of the control group was 41.38. The recurrence rate of the treatment group was significantly lower than that of the control group. Safety index: there was no adverse reaction during treatment in both groups. Conclusion 1. The clinical effect of Wenyang Hewei recipe in treating functional dyspepsia with deficiency of spleen and stomach is definite, it can improve the quality of life of the patients, and the recurrence rate is low, no adverse reactions are found, and the safety is good. It is worth popularizing and applying in clinic. The mechanism of Wenyang Hewei recipe in treating functional dyspepsia with deficiency of spleen and stomach may be related to the increase of motilin level.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

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