本文選題：參芪五苓飲 + 兒童紫癜性腎炎��； 參考：《云南中醫(yī)學(xué)院》2017年碩士論文

【摘要】：目的:通過臨床研究,觀察參芪五苓飲治療兒童脾虛濕盛型紫癜性腎炎蛋白尿的臨床療效。方法:將60例符合脾虛濕盛型的紫癜性腎炎患兒隨機(jī)、平行、對照,分為治療組和對照組,各30例。治療組給予口服參芪五苓飲,對照組給予口服腎炎康復(fù)片,兩組各治療2療程(8周)。療程結(jié)束后,觀察治療前后尿蛋白(PRO)、尿紅細(xì)胞(RBC)、尿微量蛋白(m ALB)、24小時尿蛋白(UPRO)及中醫(yī)癥候的變化。結(jié)果:1.臨床的總療效比較:治療8周后兩組患兒的總有效率比較,治療組患兒的總有效率為86.67%,對照組患兒的總有效率為66.67%,治療組總有效率明顯優(yōu)于對照組,可認(rèn)為差異有顯著統(tǒng)計(jì)學(xué)意義(P0.01)。2.中醫(yī)證候的總療效比較:治療8周后兩組患兒的中醫(yī)證候總有效率比較,治療組患兒中醫(yī)證候總有效率為93.3%,對照組患兒中醫(yī)證候總有效率為70.0%,治療組中醫(yī)證候總有效率明顯優(yōu)于對照組,可認(rèn)為差異有顯著統(tǒng)計(jì)學(xué)意義(P0.01)。3.中醫(yī)單項(xiàng)癥狀的療效比較:治療8周后兩組患兒中醫(yī)癥狀都較治療前有所改善(P0.05);治療后治療組患兒皮疹、飲食改善的情況優(yōu)于對照組,可認(rèn)為差異有顯著統(tǒng)計(jì)學(xué)意義(P0.01),治療組患兒體倦乏力、面黃少華、二便的改善情況優(yōu)于對照組,可認(rèn)為差異有統(tǒng)計(jì)學(xué)意義(P0.05);兩組患兒治療8周后汗出無差異,無統(tǒng)計(jì)學(xué)意義(P㧐0.05)。4.PRO、m ALB、UPRO指標(biāo)的比較:治療4周后兩組患兒PRO、m ALB、UPRO指標(biāo)組間比較差異無統(tǒng)計(jì)學(xué)意義(P㧐0.05),治療8周后兩組患兒PRO、m ALB、UPRO指標(biāo)組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患兒治療前、治療第4周、治療第8周組內(nèi)比較差異有顯著統(tǒng)計(jì)學(xué)意義(P0.01)。5.RBC指標(biāo)的比較:治療4周后兩組患兒RBC指標(biāo)組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療8周后兩組患兒RBC指標(biāo)組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患兒治療前、治療第4周、治療第8周組內(nèi)比較差異有顯著統(tǒng)計(jì)學(xué)意義(P0.01)。結(jié)論:1.參芪五苓飲可明顯改善脾虛濕盛型紫癜性腎炎患兒的癥狀。2.參芪五苓飲可明顯改善脾虛濕盛型紫癜性腎炎患兒的尿蛋白、尿微量蛋白、24小時尿蛋白。3.治療期間未發(fā)現(xiàn)明顯毒副作用及嚴(yán)重不良反應(yīng),說明參芪五苓飲是治療脾虛濕盛型紫癜性腎炎患兒安全的治療方法。
[Abstract]:Objective: to observe the clinical effect of Shenqi Wuling decoction on proteinuria of purpura purpura nephritis with spleen deficiency and dampness. Methods: 60 cases of Henoch-Schonlein purpura nephritis were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Shenqi Wuling decoction and the control group with the nephritis rehabilitation tablet. The two groups were treated for 8 weeks. After the course of treatment, the changes of urinary protein proton, urine red blood cell, urinary microalbuminuria and 24 hour urinary protein UPROP were observed before and after the treatment, as well as the symptoms of TCM. The result is 1: 1. Comparison of the total clinical efficacy: after 8 weeks of treatment, the total effective rate of the two groups was 86.67, the total effective rate of the control group was 66.67, the total effective rate of the treatment group was significantly better than that of the control group. It can be concluded that the difference is statistically significant (P 0.01). Comparison of the total curative effect of TCM syndrome: after 8 weeks of treatment, the total effective rate of TCM syndromes in the two groups was compared. The total effective rate of TCM syndrome in treatment group was 93.3g and that in control group was 70.0.The total effective rate of TCM syndrome in treatment group was obviously better than that in control group, and the difference was statistically significant. Comparison of curative effect of single symptom of TCM: after 8 weeks of treatment, the symptoms of TCM in both groups were improved compared with those before treatment, and the situation of skin rash and diet improvement in the treatment group was better than that in the control group after treatment. It can be concluded that the difference is statistically significant (P 0.01). The improvement of fatigue, Huang Shaohua and second stool in the treatment group is better than that in the control group, and there is no difference in sweating after 8 weeks of treatment between the two groups. There was no significant difference between the two groups after 4 weeks of treatment. There was no significant difference between the two groups. After 8 weeks of treatment, there was a significant difference between the two groups in the index of Prom ALBU UPRO (P0.05), and there was a significant difference between the two groups after 8 weeks of treatment (P 0.05). The children in both groups were treated for 4 weeks before treatment. There was significant difference in the RBC index between the two groups after 4 weeks of treatment (P 0.05), and there was significant difference between the two groups after 8 weeks of treatment (P 0.05). After 8 weeks of treatment, there was significant difference between the two groups in the RBC index. There were significant differences between the two groups before, 4 weeks and 8 weeks after treatment (P 0.01). Conclusion 1. Shenqi Wuling decoction can obviously improve the symptoms of spleen deficiency and dampness type purpura nephritis. Shenqi Wuling decoction can obviously improve urine protein in children with spleen deficiency and dampness type purpura nephritis. No obvious side effects and serious adverse reactions were found during the treatment, indicating that Shenqi Wuling Yin is a safe treatment for children with spleen deficiency and dampness purpura purpura nephritis.
【學(xué)位授予單位】：云南中醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R272

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