本文選題：郁解湯 + 惡性腫瘤相關(guān)性抑郁　； 參考：《西南醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:觀察自擬“郁解湯”治療惡性腫瘤相關(guān)性抑郁的臨床療效。方法:選擇62例惡性腫瘤伴抑郁的患者,隨機分成試驗組(31例)和對照組(31例),試驗組給予自擬“郁解湯”為主方的中醫(yī)藥辨證治療,對照組給予常規(guī)的中醫(yī)藥辨證治療(不含“郁解湯”中的藥物)。每日一劑,2周為一療程,共觀察4個療程。兩組患者在治療前、治療2周、4周、6周、8周后均采用漢密爾頓抑郁量化表、自制“郁證”中醫(yī)臨床癥狀量化表進行量化評分。然后匯總資料進行統(tǒng)計學(xué)分析。結(jié)果:1.兩組病例經(jīng)治療后抑郁評分均有所下降,試驗組在治療各階段抑郁評分均較對照組明顯下降(P0.05);試驗組治療后各階段評分均較治療前有明顯下降(P0.05)。2.試驗組藥物總有效率為87%,對照組為77%,兩組藥物對惡性腫瘤相關(guān)性抑郁均有效,治療2周后兩組療效相當(dāng)(P0.05),其余治療階段試驗組療效較對照組更明顯(P0.05)。3.試驗組、對照組藥物均能改善各因子評分,且試驗組治療結(jié)束后五個因子評分均較治療前有明顯改善(P0.05);試驗組在改善焦慮/軀體化、認(rèn)知障礙因子評分均較對照組有明顯療效(P0.05);試驗組藥物僅在治療2周后顯示出對體重因子評分改善的優(yōu)勢(P0.05),其余治療階段兩組藥物療效相當(dāng)(P0.05);兩組藥物對睡眠因子的改善無明顯差異(P0.05);試驗組藥物僅在治療6周后顯示出對遲緩因子評分改善的優(yōu)勢(P0.05),其余治療階段兩組藥物療效相當(dāng)(P0.05)。4.試驗組、對照組藥物均能明顯改善中醫(yī)臨床癥狀量化評分,試驗組藥物僅在治療4周后顯示出較對照組明顯的優(yōu)勢(P0.05),其余治療階段兩組藥物療效相當(dāng)(P0.05);試驗組經(jīng)治療后各階段中醫(yī)臨床量化評分均較治療前明顯下降(P0.05)。5.試驗組、對照組用藥均能明顯改善“郁證”,兩者在治療2周后療效相當(dāng)(P0.05),在其余治療階段試驗組療效較對照組顯著(P0.05)。結(jié)論:自擬“郁解湯”為主方的中醫(yī)藥辨證治療較常規(guī)的中醫(yī)藥辨證治療能明顯提高惡性腫瘤相關(guān)性抑郁的緩解率,能顯著改善焦慮/軀體化、認(rèn)知障礙因子評分,其作用機制有待進一步深入研究,以便造福更多惡性腫瘤患者,為惡性腫瘤相關(guān)性抑郁提供新的治療方式。
[Abstract]:Objective: to observe the clinical effect of Yujie decoction on malignant tumor associated depression. Methods: 62 patients with malignant tumor with depression were randomly divided into two groups: the experimental group (n = 31) and the control group (n = 31). The control group was treated with traditional Chinese medicine syndrome differentiation (excluding Yujie decoction). A daily dose of 2 weeks as a course of treatment, a total of 4 courses of observation. Two groups of patients before treatment, 2 weeks after 4 weeks and 6 weeks to 8 weeks after the use of Hamilton depression quantitative table, self-made "depression syndrome" TCM clinical symptoms quantitative scale to quantify the score. Then summarize the data for statistical analysis. The result is 1: 1. After treatment, the depression scores of the two groups were all decreased, the depression scores of the experimental group were significantly lower than those of the control group, and the scores of each stage of the treatment group were significantly lower than those of the control group. The total effective rate of drugs in the trial group was 87 and that in the control group was 77. The two groups were all effective in the treatment of malignant tumor-related depression. After 2 weeks of treatment, the efficacy of the two groups was equivalent to that of P0.05, while that of the other treatment stage was more obvious than that of the control group. In the test group and control group, the scores of each factor were improved, and the scores of five factors after the treatment were significantly improved compared with those before treatment, and the anxiety / somatization was improved in the test group. The scores of cognitive impairment factors were significantly better than those of the control group (P 0.05), the drug of the test group only showed the advantage of improving the score of body mass factor after 2 weeks of treatment, and the other two groups had the same curative effect as that of the control group, and the two groups had the same effect on sleep cause. There was no significant difference between the two groups in the improvement of P0.05A, the drug in the test group showed the advantage of improving the score of retardation factor only after 6 weeks of treatment, and the curative effect of the other two groups was equivalent to that of P0.05. 4. Both the experimental group and the control group could significantly improve the quantitative score of TCM clinical symptoms. After 4 weeks of treatment, the drugs in the test group only showed obvious advantages over the control group, and in the other treatment stage, the curative effect of the two groups was similar to that of the control group, and the clinical quantitative score of TCM in each stage of the trial group was significantly lower than that of the control group before and after the treatment. In the experimental group and control group, the "depression syndrome" was obviously improved by medication. The curative effect of both groups was similar after 2 weeks of treatment, and the effect of the test group was significantly higher than that of the control group in the other stages of treatment. Conclusion: the traditional Chinese medicine dialectical treatment with "Yu Jie Tang" as the main prescription can obviously improve the remission rate of malignant tumor-related depression, improve anxiety / somatization, and improve the score of cognitive disorders. Its mechanism needs further study in order to benefit more patients with malignant tumors and provide a new treatment for malignant tumor-associated depression.
【學(xué)位授予單位】：西南醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R277.7;R273

【參考文獻】

相關(guān)期刊論文 前10條

1 胡瑤;毛旭東;劉曉華;陳�，�;曲毅;方貽儒;施慎遜;吳彥;;中重度抑郁癥患者血清維生素D_2/D_3水平分析[J];上海交通大學(xué)學(xué)報(醫(yī)學(xué)版);2017年03期

2 張偉;俞仲毅;梅泰中;胡凱莉;劉梅;;蒺藜皂苷抗抑郁作用及機制研究[J];中國藥理學(xué)通報;2017年03期

3 惠凌云;王亞文;張琳;侯寧蕊;于學(xué)文;;血清睪酮水平與圍絕經(jīng)期抑郁癥的相關(guān)性研究[J];中國婦幼衛(wèi)生雜志;2016年04期

4 馬心慧;付瑜;曹淑杰;王雙力;武偉晶;王軍利;王芳;;重性抑郁障礙患者與腫瘤壞死因子ɑ基因啟動子區(qū)多態(tài)性的相關(guān)性研究[J];航空航天醫(yī)學(xué)雜志;2016年05期

5 劉松江;郭琦;閆s，

本文編號：1781782