本文選題：帕金森病 + 抑郁�。� 參考：《遼寧中醫(yī)雜志》2017年10期

【摘要】：目的:研究三甲復(fù)脈湯加減對(duì)姿勢(shì)步態(tài)異常(PIGD)型帕金森病(PD)患者抑郁和睡眠障礙的影響,并從神經(jīng)炎癥、氧化應(yīng)激探討其作用機(jī)理。方法:采用前瞻性、隨機(jī)、安慰劑對(duì)照試驗(yàn)設(shè)計(jì),將100例入組病例按1:1比例隨機(jī)分組,兩組均予左旋多巴+舍曲林,治療組予三甲復(fù)脈湯加減,對(duì)照組予中藥安慰劑。療程均為12周。在0、4、8、12周對(duì)HAMD、PDSS、UPDRSⅢ進(jìn)行評(píng)定,并檢測(cè)外周血IL-17、尿酸水平。結(jié)果:兩組基線資料具有可比性。隨著治療時(shí)間延長(zhǎng),兩組HAMD、UPDRSⅢ評(píng)分依次遞減,并在各時(shí)間點(diǎn)優(yōu)于治療前(P0.05),且治療12周后治療組均低于對(duì)照組(P0.05)。治療后8、12周,兩組PDSS評(píng)分均優(yōu)于治療前(P0.05),且治療組的評(píng)分改善大于對(duì)照組(P0.05)。兩組外周血IL-17、尿酸水平在各時(shí)間點(diǎn)均優(yōu)于治療前(P0.05),且在治療12周后治療組均優(yōu)于對(duì)照組(P0.05)。結(jié)論:三甲復(fù)脈湯加減可以顯著改善PIGD型PD抑郁和睡眠障礙,并能增強(qiáng)左旋多巴對(duì)運(yùn)動(dòng)癥狀的療效,其對(duì)外周血IL-17和尿酸表達(dá)的調(diào)節(jié)可能是該方作用機(jī)理之一。
[Abstract]:Aim: to study the effects of Sanjia Fumai decoction (SFMT) on depression and sleep disorder in patients with PIGD type Parkinson's disease (PD), and to explore its mechanism from neuroinflammation and oxidative stress. Methods: a prospective, randomized, placebo controlled trial was used. 100 patients in the control group were randomly divided into two groups at 1:1. Both groups were treated with levodopa sertraline, the treatment group was treated with Sanjia Fumai decoction, and the control group was treated with placebo. The course of treatment was 12 weeks. The levels of IL-17 and uric acid in peripheral blood were measured at 12 weeks after 12 weeks. Results: the baseline data of the two groups were comparable. With the prolongation of the treatment time, the score of HAMD-UPDRS 鈪，

本文編號(hào)：1777039