本文選題：扶陽益氣方 + 脾腎陽虛��； 參考：《云南中醫(yī)學(xué)院》2017年碩士論文

【摘要】：目的:通過本臨床試驗(yàn),觀察與評(píng)價(jià)扶陽益氣方治療卵巢癌化療后脾腎陽虛證的臨床療效。探討卵巢癌化療后脾腎陽虛證的治療方法和思路,為卵巢癌患者化療的順利進(jìn)行及完成提供保證,以提高卵巢癌患者生存質(zhì)量,延長生存期。方法:將符合本研究入組標(biāo)準(zhǔn)的病例,隨機(jī)分為2組:治療組30例和對(duì)照組30例。治療組用扶陽益氣方+參芪扶正注射液+常規(guī)治療,對(duì)照組僅予參芪扶正注射液+常規(guī)治療,兩組均治療1療程(14天/療程)。觀察對(duì)比治療前后兩組病例的中醫(yī)證候、生活質(zhì)量等相關(guān)指標(biāo),進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:1.兩組患者的治療后有效率:治療組有效率86.67%,對(duì)照組有效率73.33%,治療組療效優(yōu)于對(duì)照組(P0.05)。2.脾腎陽虛癥狀積分:兩組病例治療后的中醫(yī)證候積分均較前明顯下降(P0.01),但兩者療效比較:治療組療效都明顯優(yōu)于對(duì)照組(P0.05)。3.功能狀態(tài)(KPS)評(píng)分:治療后兩組病例KPS評(píng)分較治療前均有升高,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);治療后兩組病例的KPS評(píng)分組間比較,差異不顯著(P0.05)。4.生活質(zhì)量(QOL)評(píng)分:治療后兩組病例QOL評(píng)分都較前均明顯提高(P0.01);治療后兩組病例QOL評(píng)分組間比較差異極顯著(P0.01),說明治療后QOL評(píng)分提高方面治療組明顯優(yōu)于對(duì)照組。5.療效指標(biāo):兩組患者的腫瘤標(biāo)記物CA125、血常規(guī)指標(biāo)均無明顯下降或升高,差異無統(tǒng)計(jì)學(xué)意義,其P值均0.05。兩組患者免疫指標(biāo)T細(xì)胞亞群治療后較治療前均有顯著提升(P0.05),治療組明顯優(yōu)于對(duì)照組(P0.05)。6.安全指標(biāo):各組安全指標(biāo)無異常波動(dòng)(P0.05);未發(fā)生不良反應(yīng)。結(jié)論:扶陽益氣方對(duì)卵巢癌患者化療后脾腎陽虛證有明顯的療效,并能有效改善患者的中醫(yī)臨床癥狀,提高其生活質(zhì)量,該治療安全有效,無明顯毒副反應(yīng)。
[Abstract]:Objective: to observe and evaluate the clinical effect of Fuyang Yiqi prescription in treating the syndrome of deficiency of spleen and kidney yang after chemotherapy of ovarian cancer.To explore the treatment methods and ideas of spleen and kidney yang deficiency syndrome after ovarian cancer chemotherapy, to provide guarantee for the smooth progress and completion of chemotherapy in ovarian cancer patients, in order to improve the quality of life and prolong the survival time of ovarian cancer patients.Methods: the patients who met the criteria were randomly divided into two groups: treatment group (n = 30) and control group (n = 30).The treatment group was treated with Fuyang Yiqi prescription Shenqi Fuzheng injection and the control group was only treated with Shenqi Fuzheng injection. Both groups were treated for 14 days / course of treatment.Observe and compare the two groups of patients before and after treatment of TCM syndrome, quality of life and other related indicators, statistical analysis.The result is 1: 1.The effective rate after treatment was 86.67 in the treatment group and 73.33 in the control group. The curative effect of the treatment group was better than that of the control group (P 0.05).The symptom integral of deficiency of spleen and kidney yang: after treatment, the TCM syndrome scores of the two groups were significantly lower than that of the former, but the curative effect of the treatment group was significantly better than that of the control group (P 0.05N. 3).After treatment, the KPS score of the two groups was higher than that before treatment, and the difference was statistically significant (P 0.05), but there was no significant difference in the KPS score between the two groups after treatment.Quality of life (QOL) score: after treatment, the QOL scores of the two groups were significantly higher than those of the former, and the difference of the QOL scores between the two groups was very significant (P 0.01), indicating that the improvement of the QOL score in the treatment group was significantly better than that in the control group (P 0.05).Curative effect index: the tumor marker CA125 and the blood routine index of the two groups were not significantly decreased or increased, and the difference was not statistically significant (P < 0.05).The immunological index of T cell subsets in both groups was significantly higher than that before treatment, and the treatment group was significantly better than the control group.Safety index: there was no abnormal fluctuation of safety index in each group (P 0.05) and no adverse reaction.Conclusion: Fuyang Yiqi prescription has obvious curative effect on the syndrome of deficiency of spleen and kidney yang after chemotherapy in patients with ovarian cancer, and can effectively improve the clinical symptoms of Chinese medicine and improve the quality of life of the patients. The treatment is safe and effective, and has no obvious side effects.
【學(xué)位授予單位】：云南中醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R273

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