本文選題：降濁活血方 + 高脂血癥��； 參考：《安徽中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:本研究以病證結(jié)合,擬用健脾化痰,除濕祛瘀之法,觀察降濁活血方對高脂血癥痰瘀互結(jié)型患者的治療效果及安全性。方法:將中醫(yī)辨證屬痰瘀互結(jié)型且西醫(yī)確診為高脂血癥的80例患者,按其就診先后順序編為1到80號,通過隨機分組的原則將80例患者分成治療組(降濁活血方顆粒劑組)48例,對照組(中成藥血脂康膠囊組)32例,治療組給予降濁活血方(由單味顆粒劑組成,每日1貼,早晚餐后開水沖服),對照組給予血脂康膠囊(早晚餐后服用,每次2粒),療程均為4周。結(jié)果:(1)療效性評價:(1)兩組患者治療前后血脂指標(biāo)的比較:同組治療前后比較,差異有統(tǒng)計學(xué)意義(P0.01)。兩組治療后比較,治療組在降低TG水平上優(yōu)于對照組(P0.05);兩組在降低TC、LDL-C水平,差異無統(tǒng)計學(xué)意義(P0.05);在升高HDL-C水平,差異無統(tǒng)計學(xué)意義(P0.05)。(2)兩組病例治療前后血脂指標(biāo)療效的比較:治療組總有效率為83.33%,對照組總有效率為81.25%,差異無統(tǒng)計學(xué)意義(P0.05),兩組療效相當(dāng)。(3)治療前后兩組患者SOD的比較:兩組均可提高SOD水平,差異無統(tǒng)計學(xué)意義(P0.05)。(4)治療前后兩組患者CRP的比較:兩組均可降低CRP水平,差異無統(tǒng)計學(xué)意義(P0.05)。(5)治療前后兩組中醫(yī)臨床證候療效的比較:治療組總有效率為87.5%,對照組總有效率為78.3%,兩組療效比較,差異有統(tǒng)計學(xué)意義(P0.05);兩組均能改善中醫(yī)證候積分,但治療組優(yōu)于對照組,差異有統(tǒng)計學(xué)意義(P0.05);在改善中醫(yī)單項癥狀上降濁活血方組明顯優(yōu)于血脂康膠囊組,特別在胸悶、肢體沉重、便溏、食少等方面,療效比較明顯(P0.01),說明降濁活血方在改善中醫(yī)臨床癥狀方面療效優(yōu)于血脂康膠囊。(2)安全性評價:治療組48例觀察者用藥前后檢查的血、尿、大便常規(guī),CK、CK-MB、ALT、AST、BUN、Scr、UA實驗室檢驗結(jié)果均在正常醫(yī)學(xué)參考值范圍內(nèi),治療前后心電圖均正常,未見明顯改變。說明降濁活血方在臨床上使用較為安全,未發(fā)現(xiàn)不良反應(yīng)、副作用。結(jié)論:降濁活血方能降低高脂血癥患者血清中TG、TC、LDL-C、CRP水平,提高HDL-C、SOD水平,且改善患者臨床癥狀,達到抗炎、抗氧化,改善血管內(nèi)皮功能,預(yù)防動脈粥樣硬化的作用。臨床應(yīng)用安全可靠,值的推廣。
[Abstract]:Objective: to observe the efficacy and safety of Jiangzhuoxue prescription in treating hyperlipidemia patients with phlegm and blood stasis by combining disease with syndrome and using the method of invigorating spleen and resolving phlegm and removing dampness and removing blood stasis.Methods: 80 cases of hyperlipidemia diagnosed by western medicine were divided into treatment group (48 cases) according to the principle of random grouping.The control group (32 cases) treated with Xuezhikang capsule, the treatment group was given Jiangzhuo Huoxue recipe (composed of single granule, 1 paste per day, boiled water in the morning and evening), the control group was given Xuezhikang capsule (after morning and evening meal), the control group was treated with Xuezhikang capsule (morning and evening after meal).The course of treatment was 4 weeks.Results the comparison of blood lipid index before and after treatment in two groups: there was significant difference between the two groups before and after treatment (P 0.01).After treatment, the treatment group was better than the control group in reducing TG level, while the two groups had no significant difference in decreasing the level of TCU LDL-C, and increased the level of HDL-C.There was no significant difference between the two groups before and after treatment: the total effective rate of the treatment group was 83.33, and the total effective rate of the control group was 81.25. There was no significant difference between the two groups (P 0.05, P 0.05). The curative effect of the two groups was similar to that of the two groups before and after treatment, and the total effective rate of the treatment group was 83.33. The total effective rate of the control group was 81.25%.SOD levels were increased in both groups.There was no significant difference in CRP between the two groups before and after treatment. The CRP level was decreased in both groups.There was no significant difference between the two groups before and after treatment: the total effective rate of the treatment group was 87.5, the total effective rate of the control group was 78.3%, the difference between the two groups was statistically significant.But the treatment group was superior to the control group, the difference was statistically significant (P 0.05); in improving the single symptom of traditional Chinese medicine, the group of reducing turbidity and activating blood circulation was obviously superior to the group of Xuezhikang capsule, especially in the aspects of chest tightness, heavy limbs, loose stools and little food, etc.The curative effect was more obvious than that of P0.01, indicating that the curative effect of Jiangzhuoxue recipe in improving the clinical symptoms of traditional Chinese medicine was better than Xuezhikang capsule. (2) Safety evaluation: the blood and urine of 48 observers in the treatment group were examined before and after medication.The laboratory results of routine stool routine CKK-MBT test were all within the range of normal medical reference value, the electrocardiogram was normal before and after treatment, and no obvious change was found.It indicated that Jiangzhuo Huoxue prescription was safe in clinical use, no side effects and side effects were found.Conclusion: Jiangzhuo Huoxue prescription can reduce the level of serum TGN TCU LDL-CU CRP, improve the level of HDL-CU SOD, improve the clinical symptoms, achieve anti-inflammatory, anti-oxidation, improve vascular endothelial function and prevent atherosclerosis in patients with hyperlipidemia.The clinical application is safe and reliable, the promotion of value.
【學(xué)位授予單位】：安徽中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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