本文選題：輕度認(rèn)知障礙 + 三才益智��； 參考：《成都中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的：本研究以傳統(tǒng)的“三才”思維模型作為基本指導(dǎo)思想,結(jié)合竇漢卿三才穴的組方選穴特點(diǎn)及輕度認(rèn)知障礙(Mild Cognitive Impairment, MCI)的中醫(yī)發(fā)病基礎(chǔ)和基本病機(jī),精選百會(huì)、神闕和涌泉穴同時(shí)施以“三才益智”灸法治療MCI并評(píng)價(jià)其臨床療效和安全性,為艾灸治療MCI的臨床運(yùn)用提供進(jìn)一步的科學(xué)證據(jù)。方法：采用完全隨機(jī)對(duì)照的臨床研究方法,將符合試驗(yàn)研究納入標(biāo)準(zhǔn)的80例MCI患者隨機(jī)分配到灸法組和藥物組。按照不同的治療方案,灸法組采用艾灸百會(huì)、神闕和涌泉穴,隔日一次,共治療8周。藥物組口服尼莫地平30mg/次,1次/日,連續(xù)服用8周。以簡(jiǎn)易精神狀態(tài)檢查(The Mini-Mental Status Examinination, MMSE)、臨床記憶量表(Clinical Memory Scale, CMS)無(wú)意義圖形再認(rèn)評(píng)分和畫鐘測(cè)驗(yàn)(Clock Drawing Test, CDT)為療效評(píng)價(jià)指標(biāo),分別于治療前和治療2個(gè)月后,對(duì)兩種治療方案治療MCI進(jìn)行臨床療效和安全性的評(píng)價(jià)。結(jié)果：1、兩組受試者分組均衡,基線一致,可比性好。2、MMSE量表評(píng)價(jià)結(jié)果：“三才益智”灸法組MMSE量表的總分較治療前有極顯著提高(P0.01)其中回憶力、語(yǔ)言能力等項(xiàng)積分治療后較治療前有極顯著統(tǒng)計(jì)學(xué)差異(P0.01)注意力和計(jì)算力積分治療后較治療前有統(tǒng)計(jì)學(xué)差異(P0.05)。但是,治療兩個(gè)月后,灸法組和藥物組患者的MMSE量表總分、定向力、記憶力、注意力和計(jì)算力、回憶力及語(yǔ)言能力等各項(xiàng)積分的組間比較,均沒(méi)有統(tǒng)計(jì)學(xué)差異(P0.05)。3、CMS無(wú)意義圖形再認(rèn)評(píng)價(jià)結(jié)果：“三才益智”灸法組CMS無(wú)意義圖形再認(rèn)的評(píng)分較治療前有極顯著差異(P0.01),但灸法組和藥物組療效的組間比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)4、CDT評(píng)價(jià)結(jié)果：“三才益智”灸法組CDT的評(píng)分較治療前有極顯著差異(P0.01),但灸法組和藥物組療效的組間比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論：“三才益智”灸法能發(fā)揮改善MCI患者的綜合認(rèn)知功能的作用,且安全性較好,但尚不能確定“三才益智”灸法和尼莫地平之間的優(yōu)越性。
[Abstract]:Objective: this study took the traditional "three talents" thinking model as the basic guiding ideology, combined with the characteristics of the prescription selection of the Sancai point of Dou Hanqing and the milder Cognitive Impairment (MCIs), selected the basic pathogenesis and pathogenesis of traditional Chinese medicine.Shenque and Yongquan were treated with "three talents" moxibustion to treat MCI and evaluate its clinical efficacy and safety, which provided further scientific evidence for clinical application of moxibustion in treating MCI.Methods: 80 patients with MCI were randomly assigned to moxibustion group and drug group.According to different treatments, moxibustion group was treated with moxibustion at Baihui, Shenque and Yongquan every other day for 8 weeks.The drug group was given nimodipine 30mg/ once a day for 8 weeks.The Mini-Mental Status examination, the Clinical memory scale and Clinical Memory scale (CMSS) were used to evaluate the efficacy of the Mini-Mental Status examination and clock Drawing Test (CDTs) before and after 2 months of treatment, respectively.To evaluate the clinical efficacy and safety of two treatment regimens for MCI.Results: one, two groups of subjects were divided into balanced groups, the baseline was the same, and the evaluation results of MMSE scale were good. 2The total score of MMSE scale in the moxibustion group of "Sancai Yizhi" moxibustion method was significantly higher than that before treatment (P 0.01).After treatment, there was a significant statistical difference in the score of language ability between before and after treatment. (P0.01) there was a significant difference in attention and computational power after treatment and there was a significant difference between the two groups before and after treatment (P 0.05).However, after two months of treatment, the scores of total score of MMSE scale, orientation, memory, attention and calculation, recall ability and language ability of patients in moxibustion group and drug group were compared.There was no statistical difference between the two groups. There was no significant difference in the scores of CMS meaningless pattern recognition between the "Sancai Yizhi" moxibustion group and the pre-treatment group, but there was no significant difference between the moxibustion group and the drug group in the efficacy of the moxibustion group.There was significant difference in CDT score between Sancai Yizhi moxibustion group and pre-treatment group (P 0.01), but there was no significant difference between moxibustion group and drug group (P 0.05).Conclusion: Sancai Yizhi moxibustion can improve the comprehensive cognitive function of MCI patients, and the safety is good, but the superiority between Sancai Yizhi moxibustion and nimodipine can not be determined.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R246.6

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