本文選題：酸甘化陰法 + 腎性貧血　； 參考：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：[目的]1.觀察酸甘化陰法改善腎性貧血患者的臨床療效。2.探討酸甘化陰法改善腎性貧血的中醫(yī)作用機制。[方法]2015年11月至2016年12月,在黑龍江中醫(yī)藥大學(xué)附屬第二醫(yī)院腎病門診選取符合納入標準的慢性腎衰竭腎性貧血患者60例,隨機分為治療組30例,對照組30例。治療組給予基礎(chǔ)治療同時服用中藥經(jīng)驗方;對照組給予基礎(chǔ)治療同時服用益血生膠囊常規(guī)口服。療程均為8周。觀察兩組患者治療前、后的臨床癥狀、血紅蛋白、紅細胞壓積、血清白蛋白、超敏C-反應(yīng)蛋白、血肌酐、尿素氮的變化情況。[結(jié)果]1.總體療效比較:8周后,治療組總有效率86.21%,對照組總有效率為64.29%,兩組比較P0.05,差異有統(tǒng)計學(xué)意義,治療組優(yōu)于對照組。2.臨床癥狀改善情況:8周后顯示,治療組與對照組比較,P0.05,差異有統(tǒng)計學(xué)意義;兩組臨床癥狀單項積分比較,氣短懶言,神疲乏力,食少納呆,腰膝酸軟,脘腹脹滿,P0.05,差異有統(tǒng)計學(xué)意義,治療組優(yōu)于對照組,表明酸甘化陰法對腎性貧血患者的臨床癥狀具有明顯的改善作用。3.Hb、HCT、ALB變化情況:8周后治療組與對照組比較,P0.05,治療組優(yōu)于對照組,表明酸甘化陰法對腎性貧血及營養(yǎng)狀態(tài)的改善作用。4.超敏C-反應(yīng)蛋白變化情況:8周后顯示,治療組明顯降低,與對照組比較,P0.05,差異有統(tǒng)計學(xué)意義,治療組優(yōu)于對照組,表明酸甘化陰法能夠改善腎性貧血患者的微炎癥狀態(tài)。5.腎功能改善情況:SCr、BUN 8周后治療組與對照組自身比較,P0.05,差異顯著;治療后,治療組與對照組比較,P0.05,無顯著性差異,表明酸甘化陰法對腎臟的保護作用與對照組相當。[結(jié)論]1.酸甘化陰法能夠改善腎性貧血患者的臨床癥狀;2.酸甘化陰法能夠提高腎性貧血患者血紅蛋白含量及紅細胞壓積,改善腎性貧血患者的營養(yǎng)狀態(tài);3.酸甘化陰法能夠糾正腎性貧血患者的微炎癥狀態(tài);4.酸甘化陰法對腎性貧血患者具有明顯的腎臟保護作用,從而提高腎病患者的生活質(zhì)量。
[Abstract]:[objective] 1.To observe the clinical curative effect of acidoglyceration of yin in improving renal anemia.To explore the mechanism of traditional Chinese medicine (TCM) in improving renal anemia by acid-glycosylation of yin method.[methods] from November 2015 to December 2016, 60 patients with chronic renal failure (CRF) were randomly divided into treatment group (n = 30) and control group (n = 30).The treatment group was treated with traditional Chinese medicine while the control group was given basic treatment and routine oral administration of Yixuesheng capsule.The course of treatment was 8 weeks.The changes of clinical symptoms, hemoglobin, hematocrit, serum albumin, hypersensitive C-reactive protein, serum creatinine and urea nitrogen were observed before and after treatment.[result] 1.The total effective rate of the treatment group was 86.21, the total effective rate of the control group was 64.29, the difference between the two groups was statistically significant, the treatment group was better than the control group.The difference was statistically significant. The treatment group was superior to the control group.The results showed that the acidoglyceration of yin method could obviously improve the clinical symptoms of patients with renal anemia. 3. The changes of HCT and ALB in the treatment group were significantly better than those in the control group after 8 weeks compared with the control group (P 0.05), and the treatment group was superior to the control group.The results showed that acidoglycan Yin method could improve renal anemia and nutritional status. 4.After 8 weeks, the changes of hypersensitive C-reactive protein in the treatment group were significantly lower than those in the control group (P 0.05). The treatment group was superior to the control group, indicating that the acid-glycosylated yin method could improve the microinflammation state of the patients with renal anemia.The improvement of renal function in the treatment group was significantly higher than that in the control group (P 0.05) after 8 weeks, but there was no significant difference between the treatment group and the control group (P 0.05), which indicated that the protective effect of acidoglycan Yin therapy on the kidney was equal to that in the control group.[conclusion] 1.Acidoglycan-Yin method can improve the clinical symptoms of renal anemia patients.Acidoglycan Yin method can improve hemoglobin content and hematocrit in patients with renal anemia and improve nutritional status of patients with renal anemia.Acidoglycan-Yin therapy can correct the microinflammatory state in patients with renal anemia.Acidoglycan-Yin method has obvious renal protection effect on renal anemia patients, thus improving the quality of life of patients with nephropathy.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R277.5

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