發(fā)布時(shí)間：2018-04-10 15:08

  本文選題：肝氣郁結(jié) + 抑郁癥�。� 參考：《遼寧中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:本課題采用隨機(jī)對(duì)照設(shè)計(jì)的方法對(duì)針刺結(jié)合中藥內(nèi)服來治療肝氣郁結(jié)型抑郁癥進(jìn)行系統(tǒng)的研究與分析;全面對(duì)比針刺結(jié)合中藥內(nèi)服與單純口服抗抑郁藥物米氮平在療效及副作用的差異。材料與方法:研究對(duì)象主要來源就診于遼寧中醫(yī)藥大學(xué)附屬醫(yī)院腦病K2門診的肝氣郁結(jié)型的抑郁癥患者,將60例患者用計(jì)算機(jī)隨機(jī)化分組的方法分為治療組即針?biāo)幗M和對(duì)照組即西藥組。其中針?biāo)幗M采用針刺太沖、三陰交、百會(huì)、四神聰、膻中、印堂、神門、內(nèi)關(guān)結(jié)合中藥內(nèi)服保神湯的方法,針刺每日1次,每周5次(周末休息),中藥內(nèi)服每日2次,連續(xù)治療8周;西藥組口服米氮平,30mg/日一次,連續(xù)服藥8周。根據(jù)漢密爾頓抑郁量表和Asberg抗抑郁藥物副作用量表對(duì)患者進(jìn)行療效和副作用評(píng)價(jià)。結(jié)果:1.HAMD評(píng)分:治療8周后,針?biāo)幗M與西藥組均能降低HAMD評(píng)分,組內(nèi)進(jìn)行比較,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),表明兩組治療肝氣郁結(jié)型抑郁癥均有療效;組間比較HAMD評(píng)分,差異無統(tǒng)計(jì)學(xué)意義(P0.05),表明兩組的療效相當(dāng)。2.SERS評(píng)分:治療8周后,兩組比較SERS評(píng)分,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),說明針刺結(jié)合中藥內(nèi)服治療肝氣郁結(jié)型抑郁癥比口服西藥米氮平治療肝氣郁結(jié)型抑郁癥在減輕副作用方面更明顯。3.有效率:針?biāo)幗M的總有效率為76.6%,西藥組的總有效率為70.00%。兩組臨床療效比較無統(tǒng)計(jì)學(xué)意義(P0.05),表明兩組療效相當(dāng)。結(jié)論:1.針刺結(jié)合保神湯治療肝氣郁結(jié)型抑郁癥療效顯著,對(duì)HAMD減分率影響明顯。2.針刺結(jié)合保神湯治療肝氣郁結(jié)型抑郁癥在HAMD減分率、總有效率方面與口服抗抑郁藥物米氮平療效相當(dāng)。3.針刺結(jié)合保神湯治療肝氣郁結(jié)型抑郁癥在減少SERS評(píng)分、減輕藥物不良反應(yīng)方面優(yōu)于口服抗抑郁藥物米氮平。
[Abstract]:Objective: to study and analyze the treatment of depression due to stagnation of liver-qi by acupuncture combined with traditional Chinese medicine.The efficacy and side effects of acupuncture combined with traditional Chinese medicine were compared with those of oral antidepressant metozapine alone.Materials and methods: the main subjects of the study came from the depressive patients with liver qi depression in the clinic of encephalopathy K2 affiliated to Liaoning University of traditional Chinese Medicine.60 patients were randomly divided into treatment group (acupuncture group) and control group (western medicine group).The acupuncture and medicine group was treated with acupuncture of Taichong, Sanyinjiao, Baihui, Sishencong, Tanzhong, Yintang, Shenmen and Neiguan combined with traditional Chinese medicine for internal administration of Baoshen decoction. Acupuncture was given once a day, 5 times a week (weekend break, traditional Chinese medicine, 2 times a day).In the western medicine group, 30 mg of metozapine was administered once a day for 8 weeks.According to Hamilton Depression scale and Asberg antidepressant side effect scale, the curative effect and side effect were evaluated.Results 1. Hamd score: after 8 weeks of treatment, both acupuncture and medicine group and western medicine group could reduce HAMD score, and the difference was statistically significant (P 0.05), which indicated that both groups had curative effect in treating depression of stagnation of liver-qi, and compared HAMD score between the two groups.There was no significant difference between the two groups (P 0.05), indicating that the efficacy of the two groups was equal. 2. SERS score: after 8 weeks of treatment, the SERS scores were compared between the two groups.The difference was statistically significant (P 0.05), indicating that acupuncture combined with traditional Chinese medicine in the treatment of depression of stagnation of liver-qi is more obvious than oral metozapine in the treatment of depression of stagnation of liver-qi.Effective rate: the total effective rate of acupuncture and medicine group was 76. 6, and the total effective rate of western medicine group was 70. 00kum.There was no significant difference in clinical efficacy between the two groups (P 0.05), indicating that the two groups had the same curative effect.Conclusion 1.Acupuncture combined with Baoshen decoction was effective in the treatment of depression with stagnation of liver-qi, and had a significant effect on HAMD score reduction rate.Acupuncture combined with Baoshen decoction in the treatment of depression of liver-qi stagnation in the HAMD score reduction rate, the total effective rate and oral antidepressant mirtazapine equivalent to the efficacy of .3.Acupuncture combined with Baoshen decoction in the treatment of depression of liver-qi depression was superior to oral antidepressant miazapine in reducing SERS score and alleviating adverse drug reactions.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R246.6

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本文編號(hào)：1731719