本文選題：肝腎同治　切入點(diǎn)：帕金森病抑郁　出處：《廣西中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:系統(tǒng)評(píng)價(jià)“肝腎同治”中藥復(fù)方治療帕金森病抑郁(depress ion in Parkinson’s disease,DPD)的有效性和安全性。方法:通過(guò)制定嚴(yán)格的檢索策略,計(jì)算機(jī)檢索中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(CBM)、中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)(CNKI)、中文科技期刊全文數(shù)據(jù)庫(kù)(VIP)、萬(wàn)方數(shù)據(jù)知識(shí)服務(wù)平臺(tái)、中國(guó)臨床試驗(yàn)注冊(cè)中心(ChiCTR)、PubMed、Cochrane Library和Embase,檢索時(shí)間為各建庫(kù)時(shí)間到2017年1月31日,對(duì)檢索到的臨床研究文獻(xiàn)及綜述的參考文獻(xiàn)再進(jìn)行回溯性檢索和引文檢索以補(bǔ)充資料。嚴(yán)格按照納入與排除標(biāo)準(zhǔn)納入符合的文獻(xiàn)資料,資料的獲取由兩名研究員獨(dú)立完成。根據(jù)Cochrane協(xié)作網(wǎng)的偏倚風(fēng)險(xiǎn)評(píng)價(jià)工具評(píng)價(jià)偏倚風(fēng)險(xiǎn),提取資料并進(jìn)行統(tǒng)計(jì)分析。采用Revman 5.3軟件進(jìn)行數(shù)據(jù)分析,通過(guò)繪制森林圖和偏倚風(fēng)險(xiǎn)總結(jié)圖等得出綜合結(jié)論。結(jié)果:共納入15項(xiàng)研究,統(tǒng)計(jì)分析結(jié)果顯示:與對(duì)照組相比,“肝腎同治”中藥復(fù)方治療DPD在有效率、漢密頓抑郁量表(Hamilton Depression Scale,HAMD)評(píng)分比較、統(tǒng)一帕金森病評(píng)定量表(unified Parkinson diease rating scale,UPDRS)總評(píng)分比較的結(jié)果優(yōu)于對(duì)照組。納入的研究中有2項(xiàng)報(bào)道了日常生活能力量表(activity of daily living scale,ADL)評(píng)分,因存在很大的臨床異質(zhì)性,未進(jìn)行數(shù)據(jù)的合并,2項(xiàng)均發(fā)現(xiàn),治療后試驗(yàn)組與對(duì)照相比具有顯著統(tǒng)計(jì)學(xué)意義(P0.01)。9項(xiàng)研究進(jìn)行了安全性分析,其中有2項(xiàng)研究采用副反應(yīng)量表(Treatment Emergent Symptom Scale,TESS)對(duì)不良反應(yīng)進(jìn)行評(píng)價(jià),均提示差異具有顯著統(tǒng)計(jì)學(xué)意義(P0.01)。結(jié)論:本次系統(tǒng)評(píng)價(jià)提示:“肝腎同治”中藥復(fù)方治療DPD有效,但需進(jìn)行設(shè)計(jì)合理、執(zhí)行正確以及報(bào)告充分的隨機(jī)對(duì)照試驗(yàn),以進(jìn)一步獲得較高級(jí)別的臨床證據(jù)。
[Abstract]:Objective: to evaluate the efficacy and safety of "liver and kidney combined therapy" in the treatment of Parkinson's disease depress ion in Parkinson's disease.Methods: according to the strict retrieval strategy, the Chinese Biomedical Literature Database (CBMN), the Chinese academic Journal Full-text Database (CNKI), the Chinese Sci-tech Journal Full-text Database (VIPI), and the Wanfang data knowledge Service platform were searched by computer.Library and Embase of Chinese Clinical trial Registry were collected. The retrieval time was from January 31, 2017. The retrieved clinical research literatures and reviewed references were retrieved retrospectively and citation to supplement the data.According to the inclusion and exclusion criteria, the data were obtained by two researchers independently.The bias risk was evaluated according to the bias risk assessment tool of Cochrane cooperation network, and the data were extracted and analyzed statistically.Revman 5.3 software was used for data analysis and comprehensive conclusions were obtained by drawing forest map and bias risk summary map.Results: a total of 15 studies were included. The results of statistical analysis showed that compared with the control group, the effective rate of traditional Chinese medicine compound "liver and kidney treatment" for DPD was higher than that in the control group. Hamilton Depression scale scale score was compared with that in the control group.The results of the unified Parkinson diease rating scale scale were better than those of the control group.Two of the included studies reported the activity of daily living scale (ADL) score. Due to the large clinical heterogeneity, both of the two items without data were found.The safety analysis was performed in the experimental group compared with the control group (P 0.01), 2 of which were evaluated with treatment Emergent Symptom scale and TESS, which indicated that the difference was statistically significant (P 0.01).Conclusion: this systematic evaluation indicates that "liver and kidney treatment" is effective in the treatment of DPD, but it is necessary to carry out a randomized controlled trial with reasonable design, correct execution and sufficient report, in order to obtain higher grade clinical evidence.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R277.7

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