本文選題：桂芍知母湯　切入點(diǎn)：類風(fēng)濕關(guān)節(jié)炎　出處：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年20期

【摘要】：目的探討桂芍知母湯對(duì)類風(fēng)濕關(guān)節(jié)炎(RA)患者血清腫瘤壞死因子α(TNF-α)和趨化因子CX3CL1水平的影響。方法選取2012年1月-2014年1月該院門(mén)診就醫(yī)的64例RA患者為研究對(duì)象,并隨機(jī)分為觀察組和對(duì)照組,兩組各32例。對(duì)照組給予美洛昔康15 mg/次,1次/d和甲氨蝶呤15 mg/次,1次/周;觀察組患者在此基礎(chǔ)上加用桂芍知母湯1劑/d,500 ml水煎服。比較兩組治療前后血清TNF-α和CX3CL1水平。結(jié)果治療12周后,觀察組血清TNF-α和CX3CL1分別為(39.3±21.3)和(76.2±35.4)pg/ml,低于治療前的(75.3±47.2)和(160.7±58.3)pg/ml(P0.05),低于對(duì)照組治療12周后的(54.9±35.2)和(131.8±50.6)pg/ml(P0.05)。而對(duì)照組治療前后比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組達(dá)ACR70、ACR50、ACR20標(biāo)準(zhǔn)及無(wú)效的比例分別為9.4%、28.1%、56.3%和6.3%,優(yōu)于對(duì)照組的3.1%、18.8%、50.0%和28.1%,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。服藥期間所有患者未發(fā)生嚴(yán)重不良反應(yīng),觀察組、對(duì)照組不良反應(yīng)發(fā)生率分別為3.1%和0.0%,兩組比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論桂芍知母湯可降低RA患者血清TNF-α和CX3CL1水平,抑制關(guān)節(jié)的滑膜炎癥反應(yīng),提高臨床療效,安全可靠。
[Abstract]:Objective to investigate the effect of Guizhao Zhimu decoction on serum levels of tumor necrosis factor 偽 (TNF- 偽) and chemokine (CX3CL1) in patients with rheumatoid arthritis (RA). Methods Sixty-four patients with RA were selected from January 2012 to January 2014. The control group was treated with meloxicam (15 mg/ / d) and methotrexate (15 mg/ / week). On this basis, the patients in the observation group were treated with Guishao Anemarrhena Soup. The serum levels of TNF- 偽 and CX3CL1 were compared before and after treatment. Results after 12 weeks of treatment, the serum TNF- 偽 and CX3CL1 levels were compared between the two groups. The serum levels of TNF- 偽 and CX3CL1 were 39.3 鹵21.3) and 76.2 鹵35.4g / ml, respectively, which were lower than those before treatment (75.3 鹵47.2) and 160.7 鹵58.3pgml-1 / ml (0.05N), lower than those of control group (54.9 鹵35.2g / ml) and 131.8 鹵50.6pgml / ml (0.05g / ml), respectively. There was no significant difference in ACR70, ACR50, ACR20, and the invalid rates of ACR70, ACR50, ACR20 and ACR20 in the observation group were 9.40.28. 1% and 6. 3%, respectively, which were better than those in the control group (3. 1%, 18. 8% and 28. 01%, respectively). The difference was statistically significant (P 0. 05). The incidence of adverse reactions in the control group was 3.1% and 0.05%, respectively. There was no significant difference between the two groups (P 0.05). Conclusion Guishao Anemarrhena decoction can reduce the levels of TNF- 偽 and CX3CL1 in serum of RA patients, inhibit the inflammatory reaction of synovial membrane, and improve the clinical efficacy, safety and reliability.
【作者單位】： 江蘇省無(wú)錫市中醫(yī)醫(yī)院風(fēng)濕病科;
【基金】：江蘇省無(wú)錫市科技計(jì)劃項(xiàng)目(No:SE01N101)
【分類號(hào)】：R259

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