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  本文選題：補腎調(diào)周法　切入點：復發(fā)性流產(chǎn)　出處：《南京中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

【摘要】：目的：觀察中醫(yī)補腎調(diào)周法治療封閉抗體不足性復發(fā)性流產(chǎn)的臨床療效,并探討其作用機理,為日后臨床推廣以及應用提供依據(jù)。方法：收集符合納入標準的封閉抗體不足性復發(fā)性流產(chǎn)非妊娠期患者30例(證屬脾腎兩虛),予補腎調(diào)周中藥序貫口服,3個月1個療程,共兩個療程。觀察：1.治療后臨床癥狀、體征改善情況；2.治療后血封閉抗體變化情況;3.治療后血Th1 (IL-8)、Th2 (IL-6)細胞因子及Th1(IL-8)/Th2 (IL-6)水平的變化；4.治療后患者的妊娠情況。結(jié)果：1、補腎調(diào)周法不僅能顯著改善患者的臨床證候,還可有效提高患者外周血抗CD3-BE、抗CD8-BE的陽性率,降低IL-8水平和IL-8/IL-6比值,升高外周血IL-6水平,但對抗CD4-BE無明顯影響。以上免疫指標于治療前后相比較,P均0.05,有統(tǒng)計學意義。2、兩個療程后,30例患者中有7例再次妊娠,其中,6例獲得成功,1例再次流產(chǎn),妊娠成功率為20%。3、本課題30例患者經(jīng)治療,6例痊愈,占20%；18例顯效,占60%；5例有效,占16.7%；總有效率96.7%。結(jié)論：補腎調(diào)周法治療封閉抗體不足性復發(fā)性流產(chǎn)療效確切,既可雙向調(diào)節(jié)人的免疫功能,促進外周血抗CD3-BE和抗CD8-BE轉(zhuǎn)陽,減少Thl細胞因子的分泌,促進Th2細胞因子的釋放,調(diào)節(jié)Th1/Th2,促進同種免疫耐受的建立,又能顯著減輕患者脾腎兩虛的病候,改善妊娠結(jié)局,而且用藥相對安全,易于患者接受,在同種免疫型復發(fā)性流產(chǎn)的防治中具有廣闊的應用前景。
[Abstract]:Objective: To observe the clinical curative effect of traditional Chinese medicine Bushen Tiaozhou therapy blocking antibody deficiency of recurrent spontaneous abortion, and to explore its mechanism, provide the basis for clinical promotion and application after. Methods: We collected in accordance with the inclusion criteria of blocking antibody deficiency of recurrent spontaneous abortion (30 cases of patients with non pregnancy syndrome is the spleen kidney two falsely) for traditional Chinese medicine Bushen Tiaozhou, sequential oral, 3 months of 1 courses, a total of two courses: 1.. Observation after treatment, clinical symptoms, signs of improvement after treatment; 2. blood blocking antibody changes; 3. after treatment, blood Th1 (IL-8), Th2 (IL-6) cytokines and Th1 (IL-8) /Th2 (IL-6) level changes; pregnancy in 4. after treatment. Results: 1, the clinical syndrome of tkrpm can significantly improve the patients, but also can effectively improve the blood anti CD3-BE patients, the positive rate of CD8-BE, decrease the level of IL-8/IL-6 and the ratio of IL-8, the increase of IL in peripheral blood The level of -6, but no significant effect against CD4-BE. The above immune indexes before and after treatment comparison, P was 0.05,.2 was statistically significant, after two month treatment, 30 cases in 7 cases of pregnancy, among them, 6 were successful, 1 cases of abortion, pregnancy success rate is 20%.3, this topic 30 cases were cured, 6 cases were cured, accounting for 20%; 18 cases were cured, accounting for 60%; 5 cases were effective, accounting for 16.7%; the total efficiency was 96.7%. conclusion: the curative effect in the treatment of recurrent spontaneous abortion by blocking antibody deficiency the exact method of invigorating kidney and regulating menstruation, immune function can promote the two-way regulation of the peripheral blood and anti CD3-BE anti CD8-BE seroconversion, reduce the secretion of Thl cytokines, Th2 promotes the release of cytokines, regulate Th1/Th2, promote the establishment of immune tolerance, and can significantly reduce the symptoms of patients with spleen and kidney two empty, improve the outcome of pregnancy, and the medication is relatively safe and is easily accepted by patients, in alloimmune recurrent flow The prevention and control of production has a broad application prospect.

【學位授予單位】：南京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R271.9

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本文編號：1651339