本文選題：老年高血壓病　切入點(diǎn)：聚類分析　出處：《遼寧中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:本研究通過收集整理陳民教授治療EH患者的病例資料,對(duì)其處方用藥進(jìn)行相關(guān)統(tǒng)計(jì)分析,探索總結(jié)其治療EH的核心藥物、藥類、藥對(duì)、聚類方組等,總結(jié)陳民教授獨(dú)到的用藥規(guī)律及辨治經(jīng)驗(yàn),為今后治療EH提供理論和臨床依據(jù)、為醫(yī)者治療本病提供新思路。資料與方法:收集2014年2月至2016年12月期間,于遼寧省中醫(yī)院老年病科門診就診的EH患者的中藥首診處方。采集患者的姓名、性別、年齡、用藥等信息并錄入Excel表中,統(tǒng)計(jì)出用藥頻數(shù)頻率,歸經(jīng)、功效分類,結(jié)果轉(zhuǎn)換成可分析數(shù)據(jù),用統(tǒng)計(jì)學(xué)軟件(SPSS22.0)對(duì)數(shù)據(jù)進(jìn)行聚類分析,得出結(jié)論。結(jié)果:1.根據(jù)病例納入、排除標(biāo)準(zhǔn)進(jìn)行篩查和收集,共納入115例處方,得132味藥,用藥總頻次為2951次,高頻用藥頻率25%的有50味,其中前13味為核心用藥。2.用藥頻數(shù)在10次以上(含10次)的有81味,占累積總頻次的92.88%,是治療本病的常用藥物。3.歸經(jīng)最多的為:肝經(jīng);較多的依次為:脾經(jīng)、腎經(jīng)、心經(jīng)、肺經(jīng)、胃經(jīng);較少的依次為:大腸經(jīng)、膽經(jīng)、心包經(jīng)、小腸經(jīng)、膀胱經(jīng)、三焦經(jīng)。4.使用頻數(shù)最多的前七類藥依次為補(bǔ)虛藥、清熱藥、活血化瘀藥,安神藥、平肝息風(fēng)藥、利水滲濕藥、理氣藥,總頻數(shù)為2128次,占總頻次的77.64%。5.將前50味高頻藥進(jìn)行聚類分析,得到10個(gè)常用藥對(duì)及7個(gè)聚類方組。結(jié)論:1.由治療EH藥物分析可知,陳師常用補(bǔ)虛藥治療本病,佐以清熱、活血化瘀,安神、平肝息風(fēng)、利水滲濕、理氣等藥物,反映了EH本虛標(biāo)實(shí)的特殊病機(jī)特點(diǎn),并以補(bǔ)虛固本為先,辨證瀉實(shí)為要的用藥特點(diǎn)。2.由藥物歸經(jīng)可知,陳師用藥注重肝、脾、腎、心、肺、胃多臟腑并調(diào)。3.補(bǔ)虛藥在治療中占主導(dǎo)地位,其次是清熱藥、活血化瘀藥,安神藥、平肝息風(fēng)藥、利水滲濕藥、理氣藥,這七類藥是導(dǎo)師治療EH的主要藥物。4.由聚類藥對(duì)及聚類方組可知,導(dǎo)師對(duì)EH的臨證治則以調(diào)理肝腎陰陽為主,注重固護(hù)后天脾胃運(yùn)化,益氣養(yǎng)血,具體針對(duì)“風(fēng)、熱、痰、瘀、郁”等病理因素,靈活加減,辨治用藥。
[Abstract]:Objective: to collect and sort out the data of Professor Chen Min's treatment of EH patients, and to analyze the related statistics of prescribing drugs, and to explore and summarize the core drugs, drugs, drug pairs and cluster prescriptions for the treatment of EH. In order to provide theoretical and clinical basis for the treatment of EH in the future, and to provide a new idea for the treatment of this disease, Professor Chen Min's unique law of drug use and experience of differentiation and treatment are summarized. Data and methods: collected from February 2014 to December 2016, The first prescription of traditional Chinese medicine for EH patients in the outpatient department of geriatrics of Liaoning Provincial traditional Chinese Medicine Hospital. The information of name, sex, age, drug use were collected and entered into Excel table, and the frequency of drug use, meridian induction and efficacy classification were calculated. Results the data were transformed into analyzable data and cluster analysis was carried out with statistical software SPSS 22.0. Results: 1.Results: 1.According to the inclusion of cases and exclusion criteria, screening and collection were carried out. A total of #number1# prescriptions were included and 132 drugs were obtained. The total frequency of the use of drugs was 2951 times. The frequency of high frequency drug was 25%, among which the first 13 were core drugs .2.Eighty one of them had the frequency of more than 10 times (including 10 times), accounting for 92.88% of the cumulative frequency, which was the common medicine for the treatment of this disease. The most common medicine was: liver meridian; The more frequently used drugs are spleen Meridian, Kidney Meridian, Heart Meridian, Lung Meridian, stomach Meridian; the lesser ones are: large intestine Meridian, gallbladder Meridian, pericardial Meridian, small intestine Meridian, bladder Meridian, TriJiao Channel. Drugs for activating blood circulation and removing blood stasis, medicine for soothing the mind, medicine for calming the liver and relieving wind, medicine for promoting water and infiltrating dampness, medicine for regulating qi, the total frequency is 2128 times, accounting for 77.64.5.The first 50 high-frequency drugs are analyzed by cluster analysis. 10 common drug pairs and 7 cluster prescription groups were obtained. Conclusion 1. According to the analysis of the treatment of EH, Chen Shi commonly used tonifying drugs to treat this disease, with the drugs of clearing heat, activating blood circulation and removing blood stasis, calming the liver and relieving the wind, promoting water and seepage, regulating qi, and so on. It reflects the characteristics of the special pathogenesis of EH, and takes reinforcing deficiency and strengthening the original as the first, and the medicine characteristic of syndrome differentiation and diarrhea is important. 2. According to the medicine, Chen Shi pays attention to the liver, spleen, kidney, heart, lung, and so on, the medicine of Chen Shi is focused on the liver, spleen, kidney, heart, lung, and so on. Stomach multiple zang-fu organs and regulating .3. tonifying and deficiency drugs play a leading role in the treatment, followed by heat-clearing drugs, blood circulation drugs, tranquilizing drugs, calming the liver and relieving the wind medicine, promoting water and infiltrating dampness medicine, regulating qi medicine, These seven kinds of drugs are the main drugs for the treatment of EH by tutors .4.From the cluster medicine pair and the cluster prescription group, the clinical treatment of EH by the tutor is mainly to regulate the liver and kidney yin and yang, pay attention to protecting the spleen and stomach from the day after the day after, and nourish the blood, and specifically aim at "wind, heat, phlegm, blood stasis," Yu "and other pathological factors, flexible addition and subtraction, differentiation and treatment of medication."
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R249;R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 方銳;胡鏡清;彭錦;葛金文;;基于因子分析的老年高血壓中醫(yī)證素特征研究[J];中華中醫(yī)藥雜志;2016年12期

2 李海聰;楊毅玲;李求兵;王燕;楊學(xué)青;田心;陳曉光;王博元;;歸脾湯加減中藥治療老年高血壓病合并抑郁癥及對(duì)患者血壓和生活質(zhì)量的影響[J];中華中醫(yī)藥雜志;2016年08期

3 寧梢鳳;;自擬降壓湯聯(lián)合硝苯地平緩釋片治療老年高血壓的療效觀察[J];臨床醫(yī)藥文獻(xiàn)電子雜志;2016年21期

4 王華杰;;六味地黃丸合天麻鉤藤飲加減治療老年原發(fā)性高血壓的療效觀察[J];中醫(yī)臨床研究;2016年18期

5 許樹宇;萬啟南;;通脈降脂丸配合西藥治療痰瘀互結(jié)型老年高血壓35例[J];云南中醫(yī)中藥雜志;2016年06期

6 王寧忻;;加減地黃飲子聯(lián)合硝苯地平緩釋片治療陰陽兩虛型老年性高血壓的隨機(jī)對(duì)照分析[J];醫(yī)學(xué)理論與實(shí)踐;2016年05期

7 黎秋明;;老年性高血壓加味血府逐瘀湯的臨床應(yīng)用治療效果分析[J];中醫(yī)臨床研究;2016年07期

8 陳揚(yáng)波;陳勇毅;;陳勇毅論治老年高血壓病眩暈經(jīng)驗(yàn)[J];浙江中醫(yī)雜志;2015年10期

9 王冬燕;;高洪春治療老年高血壓病的經(jīng)驗(yàn)[J];山西中醫(yī);2015年09期

10 馬紹波;;趙振利主任治療老年高血壓病經(jīng)驗(yàn)[J];中西醫(yī)結(jié)合心腦血管病雜志;2015年11期

相關(guān)會(huì)議論文 前1條

1 吳燕春;蘭太進(jìn);劉舒凌;;牛膝藥理作用的研究進(jìn)展[A];第二屆臨床中藥學(xué)學(xué)術(shù)研討會(huì)論文集[C];2009年

相關(guān)碩士學(xué)位論文 前1條

1 余莉萍;張覺人教授辨證治療老年性高血壓病的經(jīng)驗(yàn)探討[D];湖北中醫(yī)藥大學(xué);2013年

，

本文編號(hào)：1648390