發(fā)布時間：2018-03-16 15:48

  本文選題：針刺　切入點：氣道重塑　出處：《中華中醫(yī)藥學刊》2017年08期 　論文類型：期刊論文

【摘要】：目的:探討針刺對支氣管哮喘氣道重塑的影響及其作用機制。方法:將30只SPF級雄性SD大鼠隨機分為空白組、模型組和針刺組,每組10只。通過HE及Masson染色法觀察各組大鼠肺組織形態(tài)結(jié)構(gòu)及氣道重塑程度,采用ELISA法檢測各組大鼠血清及肺泡灌洗液ColⅠ、FN的表達。結(jié)果:針刺組大鼠肺組織上皮下膠原沉積及平滑肌層增厚情況均較模型組有所好轉(zhuǎn)(P=0.002,0.05;P=0.006,0.05),針刺組大鼠血清及肺泡灌洗液ColⅠ、FN的含量較哮喘組顯著降低(P=0.011、P=0.002;P=0.026、P=0.026)。結(jié)論:針刺能有效緩解哮喘大鼠氣道重塑程度,且其作用機制可能與抑制ColⅠ、FN的表達有關。
[Abstract]:Objective: to investigate the effect and mechanism of acupuncture on airway remodeling of bronchial asthma. Methods: thirty SPF male SD rats were randomly divided into three groups: blank group, model group and acupuncture group. The lung structure and airway remodeling degree were observed by HE and Masson staining in 10 rats in each group. ELISA method was used to detect the expression of Col 鈪，

本文編號：1620592