本文選題：VVC　切入點：婦爽散　出處：《云南中醫(yī)學院》2017年碩士論文　論文類型：學位論文

【摘要】：目的:觀察“婦爽散”及“婦爽散”聯(lián)合雙唑泰泡騰片局部給藥治療外陰陰道假絲酵母菌病(vulvovaginal candidiasis,VVC)的臨床療效,為探尋治療VVC最佳用藥方案提供臨床研究資料。方法:將選擇符合納入標準的90例患者隨機分為三組,即兩組觀察組與一組對照組,每組各30例:中藥組予中藥婦爽散陰部坐浴及陰道沖洗治療;中西藥組予婦爽散陰部坐浴+雙唑泰泡騰片陰道治療;對照組即西藥組,予雙唑泰泡騰片陰道治療。各組均以七天為一個療程。通過觀察三組患者治療前后臨床癥狀(陰部瘙癢或灼熱疼痛、帶下等)、局部體征、白帶常規(guī)與五聯(lián)酶學檢測等方面的變化進行總結歸納,利用SPSS21.0統(tǒng)計軟件,對臨床收集的數(shù)據(jù)通過秩和檢驗、c2檢驗及t檢驗等方法,進行統(tǒng)計分析。結果:1、中藥組、中西藥組與西藥組在假絲酵母菌清除率上分別為93.3%、100%、100%,臨床癥狀總療效分別為80%、96.7%、86.7%,三組治療在假絲酵母菌清除及臨床癥狀總療效差異無統(tǒng)計學意義(P0.05)。2、白帶常規(guī)與五聯(lián)酶學檢測各項指標觀察示:(1)清潔度方面,三組療效均非常顯著(P0.01),組間比較差異無統(tǒng)計學意義(P0.05);(2)在白細胞酯酶、脯氨酸氨基肽酶方面,中西藥組療效顯著(P0.05);(3)在過氧化氫方面,中西藥組療效顯著(P0.05);(4)在乙酰氨基葡萄糖苷酶方面,中西藥組療效非常顯著(P0.01)。3、患者自覺陰部瘙癢、帶下量、帶下異味的改善方面,三組均療效非常顯著(P0.01)。在自覺帶下量改善方面,中藥組優(yōu)于中西藥組(P0.05),中西藥組優(yōu)于西藥組(P0.05);在自覺帶下色質改善方面,中藥組顯著優(yōu)于另兩組(P0.01)、中西藥組顯著優(yōu)于西藥組(P0.01);4、在改善婦檢局部體征上,中藥組療效顯著,差異有統(tǒng)計學意義(P0.05)。其中陰道分泌物改善方面,中藥組效果非常顯著,差異有顯著統(tǒng)計學意義(P0.01)。結論:1、婦爽散治療VVC臨床療效效果肯定,并能有效改善伴隨的癥狀,提高患者生活質量,療效與雙唑泰泡騰片相近。2、婦爽散在改善VVC患者自覺帶下色質、婦檢局部體征、陰道分泌物量多方面優(yōu)于雙唑泰泡騰片。3、婦爽散聯(lián)合雙唑泰泡騰片用藥在改善VVC患者自覺帶下量、色質改善方面療效優(yōu)于單純用雙唑泰泡騰片。并能明顯改善白帶的五聯(lián)酶學指標。
[Abstract]:Objective: to observe the clinical effect of "Fushuang Powder" and "Fushuang Powder" combined with bizolidate effervescent tablet in the treatment of vulvovaginal candidiasis (VVC). Methods: 90 patients who met the inclusion criteria were randomly divided into three groups: two observation groups and one control group. There were 30 cases in each group: the Chinese medicine group was treated with traditional Chinese medicine Fushuangsan pudendal sitting bath and vaginal washing; the Chinese and western medicine group received the vaginal treatment of Fushuangsan pudendal biszolidate effervescent tablet; the control group was the western medicine group. The patients in each group were treated with seven days as a course of treatment. The clinical symptoms of the three groups were observed before and after treatment (pruritus or burning pain in the pudendal region, with lower and equal symptoms, local signs, etc.). The changes of leucorrhea routine and pentagonal enzymology were summarized and summarized. The clinical data collected were statistically analyzed by rank sum test and t test by using SPSS21.0 software. The clearance rates of Candida cerevisiae in the Chinese and western medicine groups were 93.3100 and 100, respectively, and the total clinical symptoms were 86.70.There was no significant difference between the three groups in the clearance of Candida cerevisiae and the total curative effect of clinical symptoms, while the leucorrhea routine and the pentaclase were not significantly different from those in the three groups. There was no significant difference between the three groups in the clearance of Candida cerevisiae and the total curative effect of clinical symptoms. In terms of cleanliness, There was no significant difference between the three groups in the leucocyte esterase and proline aminopeptidase, while in the Chinese and western medicine group the curative effect was significantly higher than that of the western medicine group in hydrogen peroxide. The curative effect of the traditional Chinese and Western medicine group was significant (P0.05Glucosidase) in the acetylglucosaminidase group, the curative effect of the traditional Chinese and western medicine group was very significant (P 0.01). The patients were aware of the pruritus of the pudenda, the quantity and the smell of the vulva. The effect of the three groups was very significant in the improvement of the quantity under the conscious belt. The Chinese medicine group was superior to the Chinese and western medicine group (P 0.05), the traditional Chinese medicine group was superior to the western medicine group (P 0.05), the traditional Chinese medicine group was significantly better than the other two groups in improving the color quality under the conscious belt, and the traditional Chinese medicine group was significantly better than the western medicine group (P 0.01). The difference was statistically significant (P 0.05). In the improvement of vaginal secretion, the effect of traditional Chinese medicine group was very significant, and the difference was statistically significant. Conclusion the clinical effect of Wushuangsan in treating VVC is positive, and it can effectively improve the accompanying symptoms. To improve the quality of life of patients, the curative effect was similar to that of bizolidate effervescent tablets. The effect of Fushuangsan was to improve the color quality and local signs of VVC patients. The amount of vaginal secretions was better than that of bizolidate effervescent tablets in many aspects. The dosage of Fushuang Powder combined with Bizolidate effervescent tablets was improved in patients with VVC. The effect of color improvement was better than that of biszolidine effervescent tablet alone, and it could obviously improve the pentagonal enzyme index of leucorrhea.
【學位授予單位】：云南中醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R271.9

【參考文獻】

相關期刊論文 前10條

1 李雪婷;李曉玲;吳小玲;杜仲平;;自擬蛇床子苦參湯聯(lián)合雙唑泰泡騰片治療陰道炎140例療效觀察[J];湖南中醫(yī)雜志;2015年12期

2 陳陽峰;鐘曉紅;;黃柏的藥理作用及其活性成分提取[J];作物研究;2015年05期

3 馮學燾;;乳酸菌配合硝呋太爾制霉素治療RVVC的療效觀察[J];基層醫(yī)學論壇;2015年18期

4 王娜梅;崔琳;馬春芬;王慧霞;;苦參凝膠聯(lián)合氟康唑膠囊治療霉菌性陰道炎的臨床觀察[J];中國中藥雜志;2015年05期

5 李蕾;孫美利;張舒媛;魏穎;時曉娟;張晶;徐暾海;徐銅華;;近十年金蕎麥化學成分及藥理活性研究進展[J];中醫(yī)藥導報;2015年04期

6 韋思清;;霉菌性陰道炎的診斷及治療現(xiàn)狀[J];臨床合理用藥雜志;2015年01期

7 管曉麗;楊明;楊巖;;口服制霉菌素與外部用藥治療霉菌性陰道炎的療效探究[J];中國婦幼保健;2014年29期

8 陳冬紅;王艷;;中西醫(yī)結合治療復發(fā)性念珠菌性陰道炎療效觀察[J];實用中醫(yī)藥雜志;2014年08期

9 婁彥妮;田愛平;張俠;馮利;譚煌英;朱世杰;劉猛;賈立群;;中醫(yī)外治化療性周圍神經病變的多中心、隨機、雙盲、對照臨床研究[J];中華中醫(yī)藥雜志;2014年08期

10 薛武更;;孫氏清帶湯坐浴治療濕熱下注型帶下病33例[J];中國中醫(yī)藥現(xiàn)代遠程教育;2014年12期

相關博士學位論文 前1條

1 張純菁;加減龍膽瀉肝湯治療帶下病濕熱下注的臨床研究[D];廣州中醫(yī)藥大學;2011年

相關碩士學位論文 前2條

1 孫秀鳳;完帶湯治療脾虛型帶下病的臨床研究[D];廣州中醫(yī)藥大學;2012年

2 石文艷;參草護陰洗劑治療外陰陰道假絲酵母菌病的臨床研究[D];湖北中醫(yī)學院;2009年

，

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