本文選題：加味升降散　切入點：飲停胸脅型　出處：《中國實驗方劑學(xué)雜志》2017年12期 　論文類型：期刊論文

【摘要】：目的:探討飲停胸脅型結(jié)核性胸膜炎(TBP)患者應(yīng)用加味升降散對其胸腔積液腺苷脫氨酶(ADA)及外周血調(diào)節(jié)性T細(xì)胞(Treg)與樹突狀細(xì)胞(DC)細(xì)胞亞群的影響。方法:選取河北大學(xué)附屬醫(yī)院2014年1月—2015年9月收治的134例TBP患者,按照隨機(jī)數(shù)字表法均分為兩組。對照組予以胸腔穿刺抽液+抗結(jié)核藥物的常規(guī)治療;觀察組在此基礎(chǔ)上,給予加味升降散治療。記錄比較兩組連續(xù)治療2個月時臨床療效,胸腔積液ADA水平,外周血Treg與DC細(xì)胞亞群占外周血單個核細(xì)胞(PBMC)的百分比。結(jié)果:連續(xù)治療2個月后,觀察組總有效率(95.52%)高于對照組(83.58%)(P0.05)。兩組治療2個月時胸腔積液ADA水平均顯著低于治療前(P0.01);與對照組同期比較,觀察組治療2個月時胸腔積液ADA水平顯著降低(P0.01)。與治療前比較,兩組患者治療2個月時CD25~+/PBMC,CD25~+/CD4~+及CD25~+FoxP3~+/CD25~+均顯著降低(P0.01);且觀察組治療2個月時外周血Treg細(xì)胞亞群改善程度較對照組同期降低顯著(P0.01)。兩組治療2個月時DC1/PBMC,DC2/PBMC及DC1/DC2均明顯高于治療前(P0.05);且與對照組同期比較,觀察組治療2個月時外周血DC細(xì)胞亞群改善幅度更為明顯(P0.05)。結(jié)論:TBP患者在常規(guī)西醫(yī)治療基礎(chǔ)上應(yīng)用加味升降散更能有效改善其臨床癥狀,降低胸腔積液ADA水平,調(diào)節(jié)機(jī)體細(xì)胞免疫,療效切實,為臨床防治TBP提供了新思路。
[Abstract]:Objective: to investigate the effects of Jiawei Shengsheng Powder on Ada in pleural effusion, T cell subsets and dendritic cell subsets in patients with tuberculous pleurisy due to pleural arrest. Methods: to study the effect of Jiawei Shengshang Powder on the subsets of adenosine deaminase (ADAA) and peripheral blood regulatory T cells (T cells) and dendritic cells (DC) in patients with tuberculous pleurisy. From January 2014 to September 2015, 134 patients with TBP were treated in the affiliated Hospital of North University. According to the method of random number table, the control group was given routine treatment of antituberculous drugs through thoracic puncture, and the observation group was treated with Jiawei Shengshang powder on this basis. The clinical effects of the two groups were recorded and compared after 2 months of continuous treatment. The level of ADA in pleural effusion, the percentage of peripheral blood Treg and DC cell subsets in peripheral blood mononuclear cells (PBMC). Results: after 2 months of continuous treatment, The total effective rate of the observation group (95.52) was higher than that of the control group (83.58). The ADA level of pleural effusion in the two groups was significantly lower than that in the control group at 2 months after treatment, and the level of ADA in the observation group was significantly lower than that in the control group at the same time. After 2 months of treatment, CD25- / -PBMC, CD25- / -CD4and CD25- FoxP3- / CD25- decreased significantly, and the improvement of peripheral blood Treg cell subsets in the observation group was significantly lower than that in the control group at the 2nd month compared with the control group. After 2 months of treatment, DC1 / PBMCDC2P / PBMC and DC1/DC2 in the two groups were significantly lower than those in the control group. It was higher than that before treatment (P 0.05) and compared with the control group in the same period. In the observation group, the subsets of DC cells in peripheral blood were significantly improved at 2 months after treatment. Conclusion the treatment of Jiawei Shengsheng Powder on the basis of routine western medicine treatment can effectively improve the clinical symptoms and reduce the level of ADA in pleural effusion. Regulation of cellular immunity, effective, for clinical prevention and treatment of TBP provides a new idea.
【作者單位】： 河北大學(xué)附屬醫(yī)院北院;
【基金】：保定市科技局立項課題項目(10ZF059)
【分類號】：R259

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