本文選題：類風(fēng)濕性關(guān)節(jié)炎　切入點(diǎn)：蜂針　出處：《中華中醫(yī)藥學(xué)刊》2017年05期 　論文類型：期刊論文

【摘要】：目的:觀察不同劑量的蜂針對佐劑性類風(fēng)濕性關(guān)節(jié)炎(RA)大鼠血清腫瘤壞死因子-α(TNF-α)、白介素-1β(IL-1β),白介素-6(IL-6)的影響,探究不同蜂針劑量對類風(fēng)濕性關(guān)節(jié)炎的可能機(jī)制。方法:建立佐劑性類風(fēng)濕性關(guān)節(jié)炎大鼠模型,將wistar大鼠隨機(jī)分為空白組、模型組和單蜂1 min組、雙蜂1 min組、三蜂1min組、單蜂30 s組。觀察各組足趾容積以及縮足反應(yīng),同時采用ELISA檢測血清TNF-α、IL-1β、IL-6表達(dá)水平。結(jié)果:單峰1 min足趾腫脹程度低于模型組(P0.01),縮足反應(yīng)對應(yīng)長于模型組(P0.05),單蜂1 min比其余治療組改善足趾腫脹度以及延長鎮(zhèn)痛效果要強(qiáng),而對于血清中TNF-α、IL-1β、IL-6的影響,單峰1 min表達(dá)水平低于模型組(P0.05),單蜂1 min與其他治療組相比抑制炎癥細(xì)胞因子的表達(dá)較好。結(jié)論:適當(dāng)劑量的蜂針具有減輕類風(fēng)濕性關(guān)節(jié)炎大鼠足趾腫脹度和加強(qiáng)鎮(zhèn)痛效果的作用,其機(jī)制可能跟抑制RA大鼠血清TNF-α、IL-1β、IL-6的表達(dá)有關(guān),而單蜂1 min可能為類風(fēng)濕性關(guān)節(jié)炎最佳的治療劑量。
[Abstract]:Objective: to observe the effects of different doses of bee on serum tumor necrosis factor- 偽 (TNF- 偽), interleukin-1 尾 (IL-1 尾) and interleukin-6 (IL-6) in rats with adjuvant rheumatoid arthritis (RA). Methods: the rat model of adjuvant rheumatoid arthritis (RA) was established with different doses of bee needle. Wistar rats were randomly divided into blank group, model group and single bee 1min group, double bee 1min group and three-bee 1min group. The toe volume and foot contraction response were observed in 30 s group. Results: the degree of toe swelling in single peak 1 min group was lower than that in model group (P 0.01), and the foot contraction reaction was longer than that in model group. Compared with other treatment groups, single bee 1 min could improve toe swelling degree and prolong analgesia. On the other hand, the effect of TNF- 偽, IL-1 尾 and IL-6 in serum, The expression level of single peak 1 min was lower than that of the model group (P 0.05). The expression of inflammatory cytokines in single bee 1 min was better than that in other treatment groups. Conclusion: the appropriate dose of bee needle can reduce toe swelling and increase the expression of inflammatory cytokines in rats with rheumatoid arthritis. The effect of strong analgesia, The mechanism may be related to the inhibition of the expression of TNF- 偽 -IL-1 尾 -6-6 in serum of RA rats, while single bee 1 min may be the best therapeutic dose for rheumatoid arthritis.
【作者單位】： 南方醫(yī)科大學(xué)中西醫(yī)結(jié)合醫(yī)院;南方醫(yī)科大學(xué)中醫(yī)藥學(xué)院;
【基金】：國家自然科學(xué)基金項目(81303047)
【分類號】：R245

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