發(fā)布時間：2018-03-13 00:28

  本文選題：冠心病心絞痛　切入點：痰瘀證　出處：《山東中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

【摘要】：目的:系統(tǒng)評價痰瘀同治法治療冠心病心絞痛痰瘀證的臨床療效,總結歸納治療本病的用藥和組方規(guī)律。方法:運用RevMan5.3軟件進行Meta-分析、倒漏斗圖分析以及敏感性分析;搜集治療冠心病心絞痛痰瘀證的中藥方劑,借助中醫(yī)傳承輔助平臺系統(tǒng)進行方藥分析。結果:1.Meta-分析結果示:痰瘀同治法干預的治療組在治療后心絞痛有效率、心電圖有效率、中醫(yī)證候的有效率和高密度脂蛋白水平方面均高于對照組(P0.05),甘油三酯、總膽固醇、低密度脂蛋白、全血黏度低切值、全血黏度高切值、血漿黏度、纖維蛋白原、紅細胞壓積水平均低于對照組(P0.05);2.倒漏斗圖分析示:心電圖、中醫(yī)證候的有效率及總膽固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白指標可能存在發(fā)表偏倚;3.敏感性分析示:兩種不同的統(tǒng)計分析方法所得的結論未見不一致者;4.方藥分析結果示:治療冠心病心絞痛痰瘀證的藥物中使用最多的為半夏、丹參,提取藥物核心組合后得到5個新方組合。結論:1.痰瘀同治法治療冠心病心絞痛痰瘀證具有較好的臨床療效和安全性;2.冠心病心絞痛痰瘀證的治療有痰、瘀偏重之分,治療原則以通為主;3.為痰瘀同治法治療冠心病心絞痛痰瘀證提供了科學依據(jù),為臨床遣方用藥提供了新思路。
[Abstract]:Objective: to evaluate the clinical effect of phlegm and blood stasis therapy in treating angina pectoris and phlegm stasis syndrome of coronary heart disease (CHD), and summarize the medication and prescription rule. Methods: Meta- analysis, inverted funnel graph analysis and sensitivity analysis were carried out with RevMan5.3 software. Collect the prescription of traditional Chinese medicine for treating angina pectoris of coronary heart disease, and analyze the prescription with the aid of traditional Chinese medicine system. Results 1. The result of Meta- analysis shows that the effective rate of angina pectoris and electrocardiogram in the treatment group treated with phlegm and blood stasis treatment method are effective after treatment. The effective rate and high density lipoprotein level of TCM syndrome were higher than that of control group (P 0.05), triglyceride, total cholesterol, low density lipoprotein, low shear value of whole blood viscosity, high shear value of whole blood viscosity, plasma viscosity, fibrinogen, The level of hematocrit was lower than that of control group (P 0.05) 2.The analysis of inverted funnel graph showed that electrocardiogram, effective rate of TCM syndromes, total cholesterol, triglyceride, High density lipoprotein and low density lipoprotein may have publication bias 3.Sensitivity analysis shows: the conclusions of two different statistical analysis methods are not consistent. 4. Prescription analysis shows: treatment of angina pectoris of coronary heart disease. Among the drugs with phlegm-stasis syndrome, Pinellia ternata was the most used. Salvia miltiorrhiza, after extracting the core combination of medicine, five new prescription combinations were obtained. Conclusion: 1. Phlegm and blood stasis combined therapy has good clinical efficacy and safety in treating angina pectoris and phlegm stasis syndrome of coronary heart disease 2.There are phlegm and blood stasis in the treatment of coronary heart disease angina pectoris and phlegm stasis syndrome. 3. It provides a scientific basis for the treatment of angina pectoris and phlegm stasis syndrome of coronary heart disease, and provides a new idea for clinical prescriptions.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

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