發(fā)布時(shí)間：2018-03-08 21:02

  本文選題：腫瘤相關(guān)性貧血　切入點(diǎn)：脾腎兩虛　出處：《廣州中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：觀察青囊斑龍丸加減方治療脾腎兩虛型腫瘤相關(guān)性貧血的臨床觀察。方法：本研究收集的病例來(lái)自廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院腫瘤中心一區(qū)的腫瘤患者,將符合入組標(biāo)準(zhǔn)的病例隨機(jī)分為治療組與對(duì)照組,其中治療組24例病例,對(duì)照組23例病例,治療組予青囊斑龍丸加減方治療,連續(xù)服用14天,其余支持治療同空白對(duì)照組；空白對(duì)照組僅予支持治療,不予任何治療貧血的干預(yù)措施。分別于入組第0、14天進(jìn)行訪視,記錄貧血療效指標(biāo)(血紅蛋白水平)、中醫(yī)證候積分、KPS評(píng)分和安全性指標(biāo)(生化全套檢查及不良反應(yīng)的發(fā)生),最后統(tǒng)計(jì)數(shù)據(jù)利用SPSS 22.0統(tǒng)計(jì)軟件進(jìn)行分析(所有統(tǒng)計(jì)均采用雙側(cè)檢驗(yàn),當(dāng)P值≤0.05時(shí),則認(rèn)為所檢驗(yàn)差別有統(tǒng)計(jì)學(xué)意義),比較兩組的貧血療效、中醫(yī)證候療效和生活質(zhì)量療效。結(jié)果：治療組血紅蛋白水平平均較前上升4.75g/L,而對(duì)照組則下降3.39g幾,經(jīng)t檢驗(yàn)有統(tǒng)計(jì)學(xué)意義(P0.05)；但貧血療效評(píng)價(jià)方面,治療組僅有16.67%評(píng)價(jià)為有效或顯效,對(duì)照組為8.70%,經(jīng)Ridit分析無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),所以,治療組的貧血療效并不優(yōu)于對(duì)照組。在中醫(yī)證候療效方面,治療組評(píng)價(jià)為有效的有91.67%,對(duì)照組評(píng)價(jià)為有效的僅有8.70%,經(jīng)Ridit分析有統(tǒng)計(jì)學(xué)意義(P=00.05),所以,治療組的中醫(yī)證候療效要優(yōu)于對(duì)照組。在生活質(zhì)量療效方面,治療組療后卡氏評(píng)分改善的有62.50%,對(duì)照組則為8.70%,經(jīng)Ridit分析有統(tǒng)計(jì)學(xué)意義(P=00.05),所以,治療組的生活質(zhì)量療效要優(yōu)于對(duì)照組。最后,在不良事件方面,治療組與對(duì)照組均未見(jiàn)肝功能惡化及腎功能惡化,但是治療組的口干、咽痛、惡心等不良反應(yīng)比對(duì)照組的發(fā)生率要稍高,經(jīng)Ridit分析無(wú)統(tǒng)計(jì)學(xué)意義(P=0.8400.05),所以,治療組與對(duì)照組的不良事件發(fā)生率并無(wú)顯著差異。結(jié)論：運(yùn)用青囊斑龍丸加減方治療脾腎兩虛型腫瘤相關(guān)性貧血的患者,在貧血的改善上無(wú)明顯療效,但是在中醫(yī)證候及生活質(zhì)量的治療上,有明顯的療效,所以,青囊斑龍丸加減方對(duì)脾腎兩虛型腫瘤相關(guān)性貧血患者有改善癥狀、提高生活質(zhì)量的作用。
[Abstract]:Objective: to observe the clinical observation on the treatment of tumor-associated anemia with deficiency of spleen and kidney with the addition and subtraction of Qingcao Banlong Pill. Methods: the patients from the first affiliated Hospital of Guangzhou University of traditional Chinese Medicine in the first area of the tumor center were collected in this study. The patients who met the criteria were randomly divided into treatment group (n = 24) and control group (n = 23). The blank control group was treated with support therapy only, and no intervention was taken to treat anemia. The effective indexes of anemia (hemoglobin level, TCM syndromes score, KPS score and safety index) were recorded. The final statistical data were analyzed by SPSS 22.0 software (all statistics). All of them were tested on both sides. When P value 鈮，

本文編號(hào)：1585519