本文選題：益氣養(yǎng)陰　切入點(diǎn)：清熱活血　出處：《南京中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：研究目的：觀察補(bǔ)心軟脈顆粒治療氣陰兩虛夾有瘀熱型冠心病心絞痛的臨床療效,并探討可能的作用機(jī)制。研究方法：將符合診斷的冠心病心絞痛患者隨機(jī)分為對照組20例,治療組20例,對照組予常規(guī)西藥治療,治療組在常規(guī)西藥治療的基礎(chǔ)上加用補(bǔ)心軟脈顆粒,連續(xù)服用8周,4周為1療程,觀察兩個療程。觀察兩組在治療前后心絞痛及中醫(yī)證候改善情況,心電圖的變化,并檢測血脂、血流變、hs-CRP、D-D二聚體、纖維蛋白原等相關(guān)指標(biāo),判斷療效。研究結(jié)果：①補(bǔ)心軟脈組不僅可以明顯緩解冠心病患者心絞痛癥狀,而且能改善中醫(yī)證候,與對照組相比,有較好的療效,P0.05,有統(tǒng)計(jì)學(xué)差異；②在調(diào)節(jié)血脂代謝紊亂方而,補(bǔ)心軟脈組能明顯減低血清中TC、TG、LDL,提高HDL水平,顯著優(yōu)于對照組；③在改善血液流變學(xué)方面,補(bǔ)心軟脈組可降低全血粘度水平、血漿粘度、紅細(xì)胞剛性指數(shù)、D-D二聚體、纖維蛋白原(FIB)含量,療效優(yōu)于對照組;④在抑制炎癥反應(yīng)方面,治療后兩組患者血清中hs-CRP水平均有所下降,但兩組之間無統(tǒng)計(jì)學(xué)差異；⑤治療期間未發(fā)現(xiàn)有不良反應(yīng)。研究結(jié)論：補(bǔ)心軟脈顆粒在治療氣陰兩虛夾有瘀熱證冠心病患者中有較好的臨床療效,可能與其調(diào)節(jié)脂質(zhì)代謝、改善血液流變學(xué)有關(guān)。
[Abstract]:Objective: to observe the clinical effect of Buxinruangmai granule in treating angina pectoris of coronary heart disease with deficiency of Qi and yin, and to explore the possible mechanism. Methods: twenty patients with angina pectoris of coronary heart disease, who were diagnosed according to the diagnosis, were randomly divided into control group (n = 20). There were 20 cases in the treatment group, the control group was treated with routine western medicine, and the treatment group was treated with Buxinluangmai granule on the basis of the routine western medicine. The treatment group was treated continuously for 8 weeks and 4 weeks as a course of treatment. Observe two courses of treatment. Observe the improvement of angina pectoris and TCM syndromes before and after treatment, the changes of electrocardiogram, and detect blood lipid, hs-CRPPD-D dimer, fibrinogen and other related indexes. The results showed that the treatment group not only alleviated the symptoms of angina pectoris in patients with coronary heart disease, but also improved the syndrome of traditional Chinese medicine. Compared with the control group, it had a better curative effect (P 0.05). There was a statistical difference between the two groups in regulating the disorder of blood lipid metabolism. The level of HDL in serum was significantly decreased and the level of HDL was increased in the group of tonifying the heart soft vein, which was significantly better than that in the control group in improving hemorheology. The group of tonifying the soft vein of the heart could reduce the whole blood viscosity, plasma viscosity, erythrocyte rigidity index and D-D dimer. The content of fibrinogen FIB4 was better than that of the control group in inhibiting inflammatory reaction. After treatment, the serum levels of hs-CRP in both groups were lower than those in the control group. However, there was no statistical difference between the two groups during the treatment period, no adverse reactions were found. Conclusion: Buxinhuangmai granule has a better clinical effect in treating coronary heart disease with deficiency of Qi and Yin with blood stasis and heat, and may regulate lipid metabolism. Related to improving hemorheology.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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