本文選題：加味丹梔逍遙散　切入點：郁病　出處：《云南中醫(yī)學(xué)院》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:觀察加味丹梔逍遙散治療郁病(焦慮抑郁狀態(tài))肝郁氣滯證的臨床療效。方法:將64例受試者依照隨機數(shù)字表分為治療組、陽性對照組各32例。治療組予加味丹梔逍遙散,服法:70ml/次,tid。陽性對照組口服黛力新,服用法:早餐中間服1片,用藥時間為4周。治療前和治療2、4周記錄中醫(yī)證候、漢密爾頓焦慮(HAMA)、漢密爾頓抑郁(HAMD)量表,治療前、治療結(jié)束記錄匹茲堡睡眠質(zhì)量指數(shù)(PSQI)量表,以評定患者焦慮、抑郁程度及睡眠質(zhì)量,統(tǒng)計各量表積分,總結(jié)有效率。.結(jié)果:1、加味丹梔逍遙散能明顯減低受試者的中醫(yī)癥候量表積分、HAMA量表積分、HAMD量表積分、PSQI量表積分,治療前后比較,有顯著差異(P0.01)。中醫(yī)癥候量表總有效率為84.38%,HAMA量表總有效率為87.50%,HAMD量表總有效率為78.13%,PSQI量表總有效率為87.50%。2、黛力新能明顯減低受試者的中醫(yī)癥候量表積分、HAMA量表積分、HAMD量表積分、PSQI量表積分,治療前后比較,有顯著差異(P0.01)。中醫(yī)癥候量表總有效率為78.13%,HAMA量表總有效率為81.28%,HAMD量表總有效率為84.38%,PSQI量表總有效率為84.38%。3、加味丹梔逍遙散與黛力新在減低患者中醫(yī)癥候量表積分、HAMA量表中精神焦慮積分、HAMD量表積分、PSQI量表積分方面比較,無統(tǒng)計學(xué)差異(P0.05),兩者在減低HAMA量表軀體焦慮積分方面比較,有統(tǒng)計學(xué)意義(P0.05)。4、兩組治療期間血常規(guī)及肝腎功未出現(xiàn)異常,且未見不良反應(yīng)發(fā)生。結(jié)論:加味丹梔逍遙散治療郁病(焦慮抑郁狀態(tài))肝郁氣滯證是有效且安全的,其在改善中醫(yī)癥狀、精神焦慮癥狀、抑郁癥狀及失眠癥狀上與陽性對照藥黛力新療效相當(dāng),在改善軀體焦慮癥狀上優(yōu)于黛力新,因而加味丹梔逍遙散值得臨床推廣運用及進一步實驗研究。
[Abstract]:Objective: to observe the clinical effect of Jiawei Dan Zhi Xiaoyao Powder on stagnation of qi and liver qi in patients with depression (anxiety and depression). Methods: 64 subjects were divided into treatment group according to random digital table. There were 32 cases each in the positive control group. The treatment group was treated with Jiawei Dan Zhi Xiaoyao Powder, taking the method of: 70 ml / times tid. The positive control group took Delixin orally. The positive control group took 1 tablet in the middle of breakfast for 4 weeks. The TCM syndromes were recorded before treatment and 2 weeks after treatment. Before treatment, the Pittsburgh Sleep quality Index (PSQI) was recorded at the end of treatment to assess the anxiety, depression and sleep quality of the patients. Results the effective rate was 1.Results: 1, Jiawei Danzhi Xiaoyao Powder could significantly reduce the TCM symptom scale integral / Hamd scale integral and PSQI scale integral, and compare before and after treatment. The total effective rate of TCM symptom scale was 84.380.The total effective rate of Hama scale was 87.50 and the total effective rate of Hamd scale was 78.13and the total effective rate of PSQI scale was 87.50.2.The total effective rate of TCM symptom scale Hama scale and Hamd scale was obviously reduced. PSQI scale integral, Comparison before and after treatment, The total effective rate of TCM symptom scale was 81.28 and the total effective rate of Hamd scale was 84.38. The total effective rate of PSQI scale was 84.38.3. Jiawei Dan Zhi Xiaoyao San and Dai Lixin were in Hama scale. The scores of mental anxiety and Hamd scale were compared with those of PSQI scale. There was no significant difference between the two groups in reducing the score of body anxiety in HAMA scale. There was no significant difference between the two groups in terms of blood routine and liver and kidney function during treatment. Conclusion: Jiawei Danzhi Xiaoyao Powder is effective and safe in the treatment of stagnation of qi of liver in patients with depression of anxiety and depression. It can improve the symptoms of TCM and mental anxiety. The depressive symptoms and insomnia symptoms were similar to those of the positive control drug Delixin, which was superior to Delixin in improving the symptoms of somatic anxiety. Therefore, Jiawei Danzhi Xiaoyao Powder is worthy of clinical popularization and further experimental study.
【學(xué)位授予單位】：云南中醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R277.7

【參考文獻】

相關(guān)期刊論文 前10條

1 張愛蘭;裴永菊;單海娟;;黛力新與艾司唑侖治療肺癌失眠的療效比較[J];中國實用神經(jīng)疾病雜志;2015年24期

2 宋美卿;馮瑪莉;馬瀾;賈力莉;牛艷艷;白崇智;;對藥香櫞佛手對抑郁大鼠T細(xì)胞亞群的影響[J];山西中醫(yī);2015年11期

3 張利;;白芍的藥理作用及現(xiàn)代研究進展[J];中醫(yī)臨床研究;2014年29期

4 郭曉冬;許二平;李琳;姚建平;衛(wèi)向龍;;加味丹梔逍遙散對抑郁模型大鼠海馬內(nèi)鹽皮質(zhì)激素受體和糖皮質(zhì)激素受體的影響[J];中國實驗方劑學(xué)雜志;2014年11期

5 譚清澈;張家堂;崔榮太;徐全剛;邢小微;孫婷婷;;三級綜合醫(yī)院神經(jīng)內(nèi)科門診患者焦慮抑郁狀態(tài)特點[J];中國健康心理學(xué)雜志;2014年05期

6 范麗容;;逍遙散加減治療卒中后焦慮、抑郁的療效觀察[J];實用中西醫(yī)結(jié)合臨床;2013年04期

7 張艷霞;張紅旗;張娟;;綜合醫(yī)院內(nèi)科住院患者焦慮抑郁狀況調(diào)查[J];中國實用醫(yī)藥;2013年18期

8 馬驍;王建;黃聰;羅鳳娟;鄭新光;曾南;夏厚林;;厚樸炙遠志炮制品的安神和祛痰作用研究[J];中藥藥理與臨床;2013年01期

9 李英杰;郭英俊;李亞楠;徐謙;王冰潔;孔桂良;;右佐匹克隆聯(lián)合氟哌噻噸/美利曲辛治療失眠伴發(fā)抑郁和(或)焦慮狀態(tài)的療效觀察[J];河北醫(yī)藥;2012年24期

10 于春泉;李苒;張敏;高杉;王怡;;柴胡-白芍藥對抗抑郁作用的實驗研究[J];中國實驗方劑學(xué)雜志;2012年23期

，

本文編號：1573535