本文選題：酒精性脂肪肝　切入點(diǎn)：中醫(yī)藥療法　出處：《青島大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:觀察健脾理氣化濁方治療酒精性脂肪肝的臨床療效,期望能為中醫(yī)治療酒精性脂肪肝提供新的思路。方法:按照嚴(yán)格的入選標(biāo)準(zhǔn)及排除標(biāo)準(zhǔn),選取80例AFL患者,隨機(jī)分為中藥組和西藥組,每組各40例,兩組患者性別、平均年齡、飲酒年限、原發(fā)病情況等基本一致,具有可比性(P0.05)。中藥組給予中藥健脾理氣化濁方治療,日1劑,早晚水煎約300ml服用,西藥組給予口服多烯磷脂酰膽堿膠囊治療,每日3次口服,每次2粒,療程均為12周。比較治療前后肝臟脂肪變性程度,肝功能指標(biāo)ALT、AST、GGT,血脂TC、TG及中醫(yī)癥候積分的變化,并作出評價(jià)。結(jié)果:1.兩組治療前后肝臟脂肪變性程度:中藥組有明顯改善(P0.01),西藥組有改善(P0.05),但中藥組優(yōu)于西藥組(P0.05)。2.兩組治療前后肝功能比較:中藥組組內(nèi)比較ALT、AST、GGT均明顯降低(P0.01),西藥組組內(nèi)比較ALT、AST、GGT差異有統(tǒng)計(jì)學(xué)意義(P0.05),且中藥組優(yōu)于西藥組(P0.05)。3.兩組治療前后血脂比較:兩組治療前后TC、TG組間對比具有統(tǒng)計(jì)學(xué)意義(P0.05),且中藥組優(yōu)于西藥組(P0.05)。4.兩組治療前后中醫(yī)癥候積分比較:中醫(yī)癥候積分屬輕度者,兩組積分無明顯差異(P0.05),但中重度者中醫(yī)證候積分有顯著差異(P0.05)。5.兩組總體療效比較:中藥組總有效率為97.5%,西藥組總有效率為75%,差異有統(tǒng)計(jì)學(xué)意義(P0.05),說明中藥組療效明顯優(yōu)于西藥組。結(jié)論:健脾理氣化濁方對于酒精性脂肪肝患者有顯著的療效,并能在很大程度上改善肝臟細(xì)胞的脂肪化,治療總體有效率明顯高于單獨(dú)服用多烯磷脂酰膽堿膠囊。
[Abstract]:Objective: to observe the clinical effect of Jianpi Liqi Zhuo recipe in the treatment of alcoholic fatty liver, hoping to provide a new idea for the treatment of alcoholic fatty liver in TCM. Methods: according to the strict selection criteria and exclusion criteria, 80 patients with AFL were selected. They were randomly divided into traditional Chinese medicine group and western medicine group with 40 cases in each group. The two groups had the same sex, average age, drinking years, primary disease and so on. The traditional Chinese medicine group was treated with traditional Chinese medicine Jianpi liqi-zhuo prescription, 1 dose per day. Morning and evening decoction about 300ml, western medicine group was given oral polyene phosphatidylcholine capsule, oral three times a day, each time 2 capsules, the course of treatment was 12 weeks. The degree of hepatic steatosis was compared before and after treatment. The changes of liver function index (alt) ASTT GGTT, TG of blood lipid and TCM symptom integral. Results: before and after treatment, the degree of hepatic steatosis in Chinese medicine group and western medicine group was significantly improved, but it was better than that in western medicine group before and after treatment. The liver function of the two groups was compared before and after treatment: the liver function of traditional Chinese medicine group was compared with that of alt ASTGGT group. The difference of GGT between western medicine group and western medicine group was statistically significant (P 0.05), and that of traditional Chinese medicine group was better than that of western medicine group (P 0.05). 3. Comparison of blood lipids between two groups before and after treatment: the comparison between two groups before and after treatment had statistical significance (P 0.05), and the traditional Chinese medicine group was better than western medicine group (P 0.05). Comparison of TCM symptom score before and after treatment between the two groups: the score of TCM symptom was mild, There was no significant difference in the scores between the two groups, but there was a significant difference in the score of TCM syndromes between the two groups. The total effective rate of the two groups was 97.5g in the traditional Chinese medicine group and 75cm in the western medicine group, indicating that the curative effect of the traditional Chinese medicine group was higher than that of the traditional Chinese medicine group (P 0.05). Conclusion: Jianpi Liqi zhuo prescription has significant curative effect on alcoholic fatty liver. The total effective rate of treatment was significantly higher than that of polyenylphosphatidylcholine capsule alone.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

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