本文選題：急性痛風(fēng)性關(guān)節(jié)炎　切入點(diǎn)：四妙痛風(fēng)湯　出處：《河南中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:觀察應(yīng)用四妙痛風(fēng)湯聯(lián)合秋水仙堿治療急性痛風(fēng)性關(guān)節(jié)炎(濕熱痹阻證)臨床療效,記錄治療前后實(shí)驗(yàn)室指標(biāo)(BUA、CRP)的變化,通過(guò)對(duì)數(shù)據(jù)的對(duì)比分析,探討四妙痛風(fēng)湯聯(lián)合秋水仙堿對(duì)急性痛風(fēng)性關(guān)節(jié)炎的防治作用。方法:篩選自河南省中醫(yī)院(河南中醫(yī)藥大學(xué)第二附屬醫(yī)院)風(fēng)濕骨病科門診的急性痛風(fēng)性關(guān)節(jié)炎患者,證型為濕熱痹阻證,60例,將采集到的病例隨機(jī)分成治療組和對(duì)照組,每組都是30例,各組全部進(jìn)行醫(yī)院正常的常規(guī)治療,對(duì)照組的治療方案為:口服秋水仙堿:1.0mg/次,2次/d。治療組在此基礎(chǔ)上加上四妙痛風(fēng)湯,每日一劑,水煎服,早晚各200ml,由藥房統(tǒng)一煎熬。兩組都是七天一個(gè)療程。記錄收集兩組患者1療程治療前后的臨床癥狀評(píng)分、療效及實(shí)驗(yàn)室指標(biāo)BUA、CRP的數(shù)值,并進(jìn)行統(tǒng)計(jì)分析。軟件采用SPSS20.0軟件包,所有結(jié)果均為計(jì)算機(jī)直接輸出。結(jié)果:一療程治療后兩組均取得了一定療效。治療組和對(duì)照組的總有效率分別為97.00%、90.00%。治療組的總有效率要比對(duì)照組高,兩組進(jìn)行比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。兩組的癥狀積分在治療前后都進(jìn)行組內(nèi)對(duì)比,結(jié)果顯示都具有統(tǒng)計(jì)學(xué)意義(P0.05),兩組治療后在癥狀積分方面都有改善。兩組的癥狀積分進(jìn)行組間對(duì)比,治療前進(jìn)行對(duì)比無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療后進(jìn)行對(duì)比具有統(tǒng)計(jì)學(xué)意義(P0.05),治療組在改善臨床癥狀評(píng)分要優(yōu)于對(duì)照組。兩組的BUA和CRP在治療前后都進(jìn)行組內(nèi)對(duì)比,均具有統(tǒng)計(jì)學(xué)意義(P0.05),兩組在治療后BUA和CRP均有改善。兩組BUA進(jìn)行組間對(duì)比,治療前兩組的BUA對(duì)比無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療后兩組的BUA對(duì)比結(jié)果顯示具有統(tǒng)計(jì)學(xué)意義(P0.05),治療組在BUA改善方面優(yōu)于對(duì)照組。兩組CRP組間對(duì)比,治療前兩組CRP對(duì)比無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療后兩組CRP對(duì)比結(jié)果顯示具有統(tǒng)計(jì)學(xué)意義(P0.05),治療組在CRP改善方面優(yōu)于對(duì)照組。結(jié)論:1、治療組和對(duì)照組均能夠減輕急性痛風(fēng)性關(guān)節(jié)炎(濕熱痹阻證)患者的臨床癥狀,改善患者的血尿酸及C反應(yīng)蛋白;2、治療組在降低急性痛風(fēng)性關(guān)節(jié)炎(濕熱痹阻證)患者實(shí)驗(yàn)室指標(biāo)(血尿酸、C反應(yīng)蛋白)及改善臨床癥狀方面優(yōu)于對(duì)照組,值得臨床推廣應(yīng)用。
[Abstract]:Objective: to observe the clinical efficacy of Simiao Tongfeng decoction combined with colchicine in the treatment of acute gouty arthritis (damp-heat arthralgia and obstruction syndrome), and to record the changes of laboratory index BUAP before and after treatment, and to compare and analyze the data. To explore the preventive and therapeutic effects of Simiao gout decoction combined with colchicine on acute gouty arthritis methods: the patients with acute gouty arthritis were selected from the Department of Rheumatology and Orthopedics Department of Henan traditional Chinese Medicine Hospital (the second affiliated Hospital of Henan University of traditional Chinese Medicine). There were 60 cases of dampness and heat obstruction syndrome. The collected cases were randomly divided into treatment group and control group, 30 cases in each group, all of which were treated with normal routine treatment in hospital. The treatment plan of the control group was oral colchicine: 1.0 mg / twice / d. On this basis, the treatment group added Simiao gout decoction, one dose daily, water decoction, In the morning and evening, 200 ml of each patient was subjected to unified suffering by the pharmacy. The two groups were treated with a course of treatment for seven days. The clinical symptom score, curative effect and the value of BUAN CRP before and after one course of treatment were recorded and analyzed in the two groups, and the software was analyzed by SPSS20.0 software package. Results: after a course of treatment, the two groups achieved certain curative effects. The total effective rates of the treatment group and the control group were 97.00 and 90.00.The total effective rate of the treatment group was higher than that of the control group, and the two groups were compared. The symptom scores of the two groups were compared before and after treatment. The results showed that there were significant differences in the symptom scores between the two groups after treatment, and the symptom scores of the two groups were compared between the two groups. There was no significant difference before treatment (P 0.05), but after treatment the comparison was statistically significant (P 0.05). The clinical symptom score of the treatment group was better than that of the control group. The BUA and CRP of both groups were compared before and after treatment. BUA and CRP were improved in both groups after treatment, and BUA was compared between the two groups. There was no significant difference in BUA between the two groups before treatment (P 0.05). The results of BUA comparison between the two groups were statistically significant after treatment. The improvement of BUA in the treatment group was better than that in the control group. There was no significant difference in CRP between the two groups before treatment (P 0.05). After treatment, the results of CRP contrast showed that there was significant difference between the two groups. The improvement of CRP in the treatment group was better than that in the control group. Conclusion: the treatment group and the control group can reduce the acute gouty. Clinical symptoms of patients with arthritis (damp-heat arthralgia syndrome), The treatment group was superior to the control group in reducing the laboratory index (blood uric acid C-reactive protein) and improving the clinical symptoms of the patients with acute gouty arthritis (damp-heat obstruction syndrome).
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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