本文關(guān)鍵詞： 非酒精性脂肪肝病 脾虛濕阻型 資生丸湯劑 臨床療效　出處：《南京中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：研究目的：本研究旨在探討資生丸湯劑健脾助運化濕法治療脾虛濕阻型非酒精性脂肪肝病(NAFLD)的臨床療效,重點觀察資生丸湯劑對該類人群血清甘油三酯的影響,同時驗證NAFLD脾虛濕阻的中醫(yī)病機認識,為臨床上探索新的有效的中醫(yī)治療NAFLD手段打下基礎(chǔ)。研究方法：將符合標準的30例患者隨機分為治療組和對照組各15例。兩組患者均采用相同的基礎(chǔ)療法(①每天至少持續(xù)半小時的中等強度的有氧運動,不宜高強度的大量運動。②調(diào)整飲食結(jié)構(gòu),均衡營養(yǎng),限制高熱量、高脂肪食物的過度攝入。③適度并且持續(xù)、漸進的控制體重,以減輕基礎(chǔ)體重的5%10%作為前3月的減重目標,使得每周體重下降不宜超過1.6kg),并在治療期間禁止服用其他任何降脂藥物；治療組在基礎(chǔ)治療的同時予以資生丸湯劑,200ml/次,每日2次,總療程12個周,結(jié)束后觀測兩組患者治療前后血脂、肝功能、中醫(yī)證候積分及單項臨床癥狀積分等相關(guān)指標并予以比較分析。研究結(jié)果：①治療組和對照組的總有效率分別為86.7%和60.0%,兩組之間的差異具有顯著性(P0.05),治療組效果優(yōu)于對照組。②治療后兩組中醫(yī)證候積分較治療前均有降低,差異顯著(P0.05),治療組和對照組的中醫(yī)證候改善總有效率分別為93.3%和66.7%,治療組效果優(yōu)于對照組,兩組之間的差異具有顯著性(P0.05)。③單項癥狀方面,兩組癥狀積分治療后均有降低,且治療組在改善患者脅肋部不適、頭身困重、神疲乏力、食少納呆等方面療效更為顯著,組內(nèi)治療前后比較及治療后組間比較的差異均有統(tǒng)計學(xué)意義(P0.05)。④兩組治療后肝功能(ALI、AST)較治療前均降低,治療組總有效率84.62%,優(yōu)于對照組總有效率61.54%,組內(nèi)治療前后比較及治療后組間比較的差異均有統(tǒng)計學(xué)意義(P0.05)。⑤兩組治療后血脂(TG、TC、LDL-C)較治療前均降低,HDL-C較治療前有所升高：治療組和對照組的總有效率分別為86.67%和60.00%,組內(nèi)治療前后比較及治療后組間比較的差異均有統(tǒng)計學(xué)意義(P0.05)。⑥用藥安全性方面,兩組間差異無統(tǒng)計學(xué)意義(P0.05),說明本課題中藥是安全的。結(jié)論：1.資生丸湯劑對于脾虛濕阻型N4FLD并存的SHTG具有良好的臨床療效�？梢杂行Ь徑忸^身困重、脅部不適、納差、腹脹、頭暈、大便溏薄等不適,同時可以降血脂、保護肝功能：但在改善神疲乏力、形體肥胖方面,療效與對照組相當(dāng)。2.資生丸湯劑臨床用藥安全,無明顯的毒副作用,病程中可以長期服用。3.資生丸是一個適應(yīng)現(xiàn)代疾病譜良好的方子,臨床上具有重要的應(yīng)用價值。
[Abstract]:Objective: to investigate the clinical effect of Zisheng Pill decoction on treating non-alcoholic fatty liver disease with spleen deficiency and dampness obstruction, and to observe the effect of Zisheng Pill decoction on serum triglyceride in this group of people. At the same time verify the NAFLD spleen deficiency dampness obstruction of TCM pathogenesis, Methods: 30 patients who met the standard were randomly divided into treatment group (n = 15) and control group (n = 15). Both groups were treated with the same basic therapy every day. At least half an hour of moderate aerobic exercise, It is not suitable for heavy exercise of high intensity to adjust the diet structure, to balance nutrition, to limit the excessive intake of high-calorie and high-fat foods, to control the weight moderately and continuously, and to reduce the basic weight by 5% as the weight loss target of March. The weight loss should not exceed 1.6 kg per week and no other lipid-lowering drugs should be taken during the treatment. The treatment group was treated with 200 ml of Zisheng Pill decoction twice a day for a total of 12 weeks. Blood lipid and liver function were observed before and after treatment. The results showed that the total effective rates of the treatment group and the control group were 86.7% and 60.00.The difference between the two groups was significant (P 0.05), and the effect of the treatment group was better than that of the control group. The scores of TCM syndromes in the two groups were lower than those before treatment after treatment in the control group (.2). The total effective rate of TCM syndrome improvement in treatment group and control group was 93.3% and 66.7, respectively. The effect of treatment group was better than that of control group. The treatment group was more effective in improving the discomforts of the hypochondria, the head and body, the fatigue of the mind, the low intake of food, and so on. Before and after treatment, the difference between the two groups was statistically significant. The liver function of the two groups after treatment was lower than that before and after treatment, and there was no significant difference between the two groups before and after treatment, and there was no significant difference between the two groups before and after treatment. The total effective rate of the treatment group was 84.62%, which was better than the total effective rate of the control group (61.54). The differences between the two groups before and after treatment were statistically significant. The total effective rates of the treatment group and the control group were 86.67% and 60.00.The differences between the two groups before and after treatment were statistically significant. There was no significant difference between the two groups (P 0.05), which indicated that this subject was safe. Conclusion: Zisheng Pill decoction has good clinical effect on SHTG with spleen deficiency and dampness obstruction type N4FLD. It can effectively relieve head and body distress, hypochondria discomfort, anorexia and abdominal distension. Dizziness, loose stools and other discomfort can also reduce blood lipid, protect liver function: but in improving fatigue, body obesity, the curative effect is equivalent to the control group. 2. Zisheng Pill decoction is safe in clinical use and has no obvious toxic side effects. Zisheng pills can be taken for a long time during the course of the disease. Zisheng Pill is a good prescription for modern disease spectrum and has important clinical application value.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

【相似文獻】

相關(guān)期刊論文 前10條

1 ;資生丸的臨證配用[J];老年人;2004年07期

2 蔡春江;梁鳳蘭;王清賢;朱葉珊;石志敏;曹自新;;小議資生丸[J];中國中醫(yī)藥現(xiàn)代遠程教育;2010年21期

3 沈經(jīng)宇;資生丸臨床運用瑣談[J];上海中醫(yī)藥雜志;1995年07期

4 魏緒和,王瓊,楚金平;資生丸加減治療Ⅱ型糖尿病52例[J];黑龍江醫(yī)藥科學(xué);2002年01期

5 沈仲賢;資生丸在治療疑難病中的運用[J];河南中醫(yī);1999年03期

6 毛德西;脾胃良藥——資生丸[J];老年人;2004年02期

7 歐陽欽;吳春明;;資生丸輔助治療肝癌惡病質(zhì)30例[J];浙江中西醫(yī)結(jié)合雜志;2011年07期

8 朱月英;資生丸治療妊娠乳泣2例[J];安徽中醫(yī)臨床雜志;1999年03期

9 陳明;周滔;;資生丸治療慢性疑難病的臨證探析[J];中國民間療法;2011年11期

10 劉國強;資生丸治療腸道易激綜合征80例[J];國醫(yī)論壇;2003年02期

相關(guān)會議論文 前1條

1 張錫元;宋小平;;資生丸治療小兒厭食22例[A];劉弼臣教授從醫(yī)六十五周年學(xué)術(shù)思想研討會暨中華中醫(yī)藥學(xué)會兒科分會與全國中醫(yī)藥高等教育學(xué)會兒科分會全國學(xué)術(shù)交流大會論文匯編[C];2004年

相關(guān)重要報紙文章 前1條

1 祿保平 馬敏 河南省中醫(yī)院 毛德西名醫(yī)工作室;資生丸 大補坤元萬物生 脾胃健運氣血盈[N];中國中醫(yī)藥報;2014年

相關(guān)碩士學(xué)位論文 前2條

1 趙嘉麗;加減資生丸膏劑治療兒童哮喘肺脾氣虛證的療效觀察[D];黑龍江中醫(yī)藥大學(xué);2016年

2 馮玉娥;繆氏資生丸湯劑對脾虛濕阻型非酒精性脂肪性肝病患者血清甘油三酯的影響[D];南京中醫(yī)藥大學(xué);2016年

，

本文編號：1549036