發(fā)布時(shí)間：2018-02-25 23:11

  本文關(guān)鍵詞： 三焦針?lè)?阿爾茨海默病 隨機(jī)對(duì)照試驗(yàn)　出處：《遼寧中醫(yī)雜志》2017年09期 　論文類型：期刊論文

【摘要】：目的:與安理申對(duì)照評(píng)價(jià)三焦針?lè)ㄖ委熭p中度阿爾茨海默病(AD)的有效性和安全性。方法:將82例AD患者隨機(jī)分為針刺組和西藥組,針刺組給予三焦針?lè)ㄖ委?次/周加西藥模擬劑5 mg/d,西藥組給予西藥安理申5 mg/d,同時(shí)進(jìn)行假針刺3次/周,療程12周,分別于治療前后進(jìn)行中西醫(yī)療效判定標(biāo)準(zhǔn)評(píng)定。西醫(yī)判定標(biāo)準(zhǔn)主要療效指標(biāo)為ADAS-cog、CIBIC-Plus,次要療效指標(biāo)為MMSE、ADL和NPI。結(jié)果:71例患者完成試驗(yàn),兩組患者治療前后ADAScog、ADL減分及MMSE加分差異具有統(tǒng)計(jì)學(xué)意義(均P0.05),NPI得分針刺組減分差異具有統(tǒng)計(jì)學(xué)差異(P0.05),而西藥組加分差異不具有統(tǒng)計(jì)學(xué)意義(P0.05);治療12周后,兩組患者的ADAS-cog、MMSE評(píng)分差異不存在統(tǒng)計(jì)學(xué)意義(P0.05),而CIBIC-Plus、ADL和NPI評(píng)分差異具有統(tǒng)計(jì)學(xué)差異(P0.05),中醫(yī)證候療效評(píng)定針刺組臨床總有效率68.57%,西藥組為52.78%,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。治療過(guò)程中針刺組無(wú)明顯不良事件發(fā)生。結(jié)論:三焦針?lè)ㄖ委熆娠@著改善輕中度AD患者的認(rèn)知障礙、日常生活能力、神經(jīng)精神癥狀和總體功能,尤其在日常生活能力、神經(jīng)精神癥狀和總體功能方面優(yōu)于西藥安理申,安全性良好。
[Abstract]:Objective: To evaluate the control and Aricept Sanjiao acupuncture treatment of mild to moderate Alzheimer's disease (AD) is effective and safety. Methods: 82 cases of AD patients were randomly divided into acupuncture group and Western medicine group, acupuncture group was given acupuncture treatment of the 3 times / week plus Western Medicine Simulation agent 5 mg/d, Western medicine group were treated with western medicine safety Shanghai 5 mg/d, while the sham acupuncture 3 times a week, for 12 weeks, and Western medical effect before and after treatment were evaluated. The western medicine to determine the main criterion of curative effect for ADAS-cog, CIBIC-Plus, secondary efficacy indicators MMSE, ADL and NPI. results: 71 patients completed the trial, two groups of patients before and after treatment of ADAScog ADL reduced and MMSE points, the difference was statistically significant (P0.05), NPI score reduction acupuncture group had a significant difference (P0.05), and the western medicine group. The difference was not statistically significant (P0.05); after 12 weeks of treatment, two groups of patients with ADAS-cog, MMSE. The difference was not statistically significant (P0.05), CIBIC-Plus, ADL and NPI score had a significant difference (P0.05), TCM syndrome curative effect evaluation of clinical acupuncture group total effectiveness 68.57%, western medicine group was 52.78%, statistically significant differences between the two groups (P0.05). The acupuncture group during the course of treatment without obvious adverse events. Conclusion: Sanjiao acupuncture therapy can significantly improve the cognitive impairment in patients with mild moderate AD, daily life ability, neuropsychiatric symptoms and overall function, especially in daily life, neuropsychiatric symptoms and overall function is superior to the western medicine Aricept, good safety.

【作者單位】： 天津中醫(yī)藥大學(xué)第一附屬醫(yī)院;韓景獻(xiàn)全國(guó)名老中醫(yī)藥專家傳承工作室;天津中醫(yī)藥大學(xué);
【基金】：國(guó)家自然科學(xué)基金(81473766) 天津市自然科學(xué)基金重點(diǎn)項(xiàng)目(16JCZDJC36200)
【分類號(hào)】：R246.6

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 劉建設(shè);愈癡方治療阿爾茨海默病100例療效觀察[J];河北中醫(yī);2001年10期

2 萬(wàn)毅;32例阿爾茨海默病的癥候舌脈分析及思考[J];中國(guó)醫(yī)藥學(xué)報(bào);2002年12期

3 王酉鶴;張s，

本文編號(hào)：1535539