發(fā)布時(shí)間：2018-02-23 00:02

  本文關(guān)鍵詞： 趾間糜爛型足癬 苦梅散 熏洗療法 臨床觀察　出處：《成都中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：通過與0.5%聚維酮碘溶液進(jìn)行臨床觀察對(duì)比,初步探討和評(píng)價(jià)苦梅散熏洗治療趾間糜爛型足癬的療效及安全性,為趾間糜爛型足癬提供一個(gè)安全、有效的治療方案。方法：通過查隨機(jī)數(shù)字表,將70例合格受試者隨機(jī)分配到治療組(35例)和對(duì)照組(35例)。治療組采用苦梅散熏洗治療,對(duì)照組采用0.5%聚維酮碘溶液浸泡治療,療程均為2周。以皮損面積、浸漬、糜爛、滲出及瘙癢程度為臨床觀察指標(biāo),以真菌鏡檢結(jié)果為病原學(xué)觀察指標(biāo)。對(duì)兩組患者在治療前、治療第7天、治療第14天及治療結(jié)束4周后的病情予以觀察并評(píng)分,判定療效及安全性。所有觀察數(shù)據(jù)均采用SPSS21.0進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果：(1)完成臨床研究病例共65例。治療組32例,對(duì)照組33例。治療組痊愈率59.38%,愈顯率81.25%,真菌清除率81.25%；對(duì)照組痊愈率51.52%,愈顯率69.70%,真菌清除率84.85%。兩組綜合療效及真菌學(xué)療效相當(dāng)(P均0.05)。(2)治療第7天,治療組皮損面積、浸漬、滲出及瘙癢程度的改善均優(yōu)于對(duì)照組(P均0.05)。(3)治療第14天,治療組在浸漬、滲出及瘙癢程度方面較對(duì)照組有明顯改善(P均0.05),其中浸漬程度的改善有顯著性差異(P0.01)。(4)復(fù)發(fā)率方面,治療組復(fù)發(fā)率10.53%,對(duì)照組復(fù)發(fā)率17.65%,P0.05,無明顯差異。結(jié)論：(1)通過對(duì)兩組患者的綜合療效及真菌學(xué)療效進(jìn)行臨床觀察對(duì)比,發(fā)現(xiàn)苦梅散熏洗療法具有較好的抗炎、止癢、抗真菌作用,其療效與0.5%聚維酮碘溶液浸泡療法相當(dāng)。(2)苦梅散熏洗療法起效較快,能夠盡早的治療和緩解患者的臨床不適感,對(duì)趾間糜爛型足癬患者的浸漬、滲出及瘙癢程度的改善優(yōu)于0.5%聚維酮碘溶液。(3)苦梅散熏洗治療趾間糜爛型足癬安全性較好,在治療過程中未見任何不良反應(yīng),值得臨床推廣應(yīng)用。
[Abstract]:Objective: to explore and evaluate the efficacy and safety of Kumei Powder fumigation and washing in the treatment of interphalangeal erosive tinea pedis by clinical observation and comparison with 0.5% povidone iodine solution, so as to provide a safety for the treatment of intertoe erosive tinea pedis. Methods: 70 eligible subjects were randomly assigned to the treatment group (35 cases) and the control group (35 cases). The treatment group was treated with Kumei powder fumigation and the control group was treated with 0.5% povidone iodine solution. The course of treatment was 2 weeks. The lesion area, maceration, erosion, exudation and pruritus were taken as the clinical observation indexes, and the results of fungal microscopy were taken as the pathogenic indexes. The patients in the two groups were treated on the 7th day before treatment. On the 14th day of treatment and 4 weeks after treatment, the patients were observed and scored, and the efficacy and safety were evaluated. All the observed data were statistically analyzed by SPSS21.0. Results 65 cases of clinical study were completed in the treatment group, 32 cases in the treatment group, 32 cases in the treatment group, and 32 cases in the treatment group. There were 33 cases in the control group. The cure rate in the treatment group was 59.38%, the recovery rate was 81.25%, the fungal clearance rate was 81.25%; in the control group, the cure rate was 51.522%, the effective rate was 69.70%, and the fungal clearance rate was 84.85%. The improvement of the degree of exudation and pruritus was better than that of the control group (P < 0.05). On the 14th day of treatment, the degree of dipping, exudation and pruritus in the treatment group was significantly improved than that in the control group (P < 0.05), and there was significant difference in the improvement of the degree of dipping (P < 0.01). The relapse rate of the treatment group was 10.53, while that of the control group was 17.65g / P0.05.ConclusionThe comprehensive curative effect and mycological effect of the two groups were observed and compared, and it was found that Kumei Powder fumigation and washing therapy had better anti-inflammatory, anti-itch and anti-fungal effects. The curative effect is similar to that of 0.5% povidone iodine solution soaking therapy) Kumei Powder fumigation and washing therapy can treat and relieve the clinical discomfort of the patients as early as possible, and impregnate the patients with the type of foot of interphalangeal erosion, the curative effect is similar to that of 0.5% povidone iodine solution soaking therapy. The improvement of exudation and pruritus was better than that of 0.5% povidone iodine solution.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R275.9

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