本文關(guān)鍵詞： 精靈顆粒 動脈粥樣硬化 氣陰虧虛 痰熱瘀阻型　出處：《南京中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:本研究運(yùn)用精靈顆粒聯(lián)合常規(guī)西藥治療符合中醫(yī)辨證屬氣陰虧虛,痰熱瘀阻型動脈粥樣硬化患者,并以常規(guī)西藥治療作為對照組,觀察精靈顆粒治療AS的作用機(jī)制及臨床效果,為中醫(yī)從氣陰虧虛,痰熱瘀阻辨治本病提供依據(jù),為中西醫(yī)結(jié)合防治動脈粥樣硬化病變,進(jìn)而防止心腦血管病的發(fā)生提供臨床理論依據(jù)。方法:選擇符合氣陰虧虛、痰熱瘀阻證的動脈粥樣硬化患者60例,隨機(jī)分為兩組:精靈顆粒組和對照組各30例。精靈顆粒組采用精靈顆粒湯劑聯(lián)合西醫(yī)標(biāo)準(zhǔn)化治療,對照組采用單純的西醫(yī)標(biāo)準(zhǔn)化治療,通過觀察治療前后兩組患者在中醫(yī)證候積分、頸動脈超聲的結(jié)果、血脂、血流變學(xué)以及炎癥因子等方面的變化,分析兩組的差異,初步評價精靈顆粒治療AS的作用機(jī)制及臨床效果。結(jié)果:在中醫(yī)臨床癥候、頸動脈超聲、血脂、血流變、炎癥因子等方面,治療后,兩組情況均有所改善,且精靈顆粒組較對照組改善程度更明顯(P0.05);藥物安全方面,兩組患者治療前后安全性指標(biāo)均沒有明顯異常。結(jié)論:精靈顆粒聯(lián)合西藥常規(guī)治療可以更好的改善AS患者的臨床癥狀;在改善患者臨床指標(biāo)(頸動脈內(nèi)膜-中層厚度、阻力指數(shù)、血脂水平、血流變水平、炎癥因子水平)具有更明顯的優(yōu)勢;說明"益氣養(yǎng)陰、清熱解毒、活血化痰"是治療AS的重要而有效的方法,精靈顆粒是治療動脈粥樣硬化的有效方劑,且具有良好的藥物安全性。
[Abstract]:Objective: to use the spirit granule combined with conventional western medicine to treat atherosclerosis patients with deficiency of qi and yin, phlegm and heat stasis, and routine western medicine as the control group. To observe the mechanism and clinical effect of fairy granule in treating as, to provide the basis for TCM to treat this disease from deficiency of qi and yin, phlegm and heat stasis, and to prevent and treat atherosclerotic lesions with integrated Chinese and western medicine. Methods: 60 cases of atherosclerosis with deficiency of Qi and Yin and stagnation of phlegm and heat were selected. The rats were randomly divided into two groups: the genie granule group (n = 30) and the control group (n = 30). By observing the changes of TCM syndromes, carotid ultrasound, blood lipid, hemorheology and inflammatory factors before and after treatment, the differences between the two groups were analyzed. Results: the clinical symptoms, carotid ultrasound, blood lipids, hemorheology and inflammatory factors were improved in both groups after treatment. In the drug safety aspect, the safety indexes of the two groups before and after treatment were not significantly abnormal. Conclusion: the clinical symptoms of as patients can be improved better by the combination of genie granule and western medicine routine therapy. It has more obvious advantages in improving the clinical indexes (intima-media thickness of carotid artery, resistance index, blood lipid level, blood rheology level, inflammatory factor level). Huoxue Huatan "is an important and effective method for treating as, and Elf granule is an effective prescription for treating atherosclerosis and has good drug safety."
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R259

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