本文關(guān)鍵詞： 針刺 電針 波寬 頻率 肌萎縮 細胞凋亡 大鼠　出處：《上海針灸雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的篩選電針治療肌萎縮的優(yōu)化電脈沖參數(shù)并探討機理。方法 SD大鼠40只,制作下肢肌萎縮模型后隨機分為A組(模型組,不電針)、B組(波寬0.5 ms,頻率2 Hz)、C組(波寬200 ms,頻率2 Hz)、D組(波寬200 ms,頻率1/2/3 Hz)。電針足三里和承山穴,共4個療程。觀察坐骨神經(jīng)功能指數(shù)(SFI)、腓腸肌濕重比(GW)、腓腸肌纖維橫截面積比(GC)、腓腸肌細胞直徑比(GD)和腓腸肌細胞凋亡指數(shù)(AI)的變化。結(jié)果與A組比,C組和D組的SFI、GW、GC明顯增大,AI明顯減小(P0.05);與B組比,C組、D組的AI明顯減小(P0.05);與C組比,D組的AI明顯減小(P0.05)。結(jié)論以波寬200 ms,頻率1/2/3 Hz的電脈沖延緩肌萎縮為優(yōu)化電針參數(shù),其機制與抑制肌細胞凋亡有關(guān)。
[Abstract]:Objective to select the optimal parameters of electroacupuncture for muscle atrophy and to explore the mechanism. Methods Forty SD rats were randomly divided into group A (model group, no electroacupuncture) after making the model of lower extremity muscle atrophy. Group B (wave width 0.5 Ms), frequency 2 Hz group C (wave width 200 Ms), frequency 2 Hz group D (wave width 200 Ms). Frequency 1 / 2 / 3 Hz. Electroacupuncture at Zusanli and Chengshan for 4 courses. The sciatic nerve function index (SFI), gastrocnemius wet weight ratio (GWN) and gastrocnemius fiber cross-sectional area (GC) were observed. Results compared with group A and group A, SFIGWN GC was significantly increased in group C and D, and the ratio of diameter of gastrocnemius cells to GD) and apoptosis index of gastrocnemius muscle cells were significantly higher than those in group A (P < 0.05). Ai decreased significantly (P 0.05); Compared with group B, AI in group C and group D decreased significantly (P 0.05). Compared with group C, AI in group D was significantly lower than that in group C. conclusion the optimal parameters of electroacupuncture are to delay muscle atrophy with a wave width of 200 Ms and a frequency of 1 / 2 / 3 Hz. The mechanism is related to the inhibition of myocyte apoptosis.
【作者單位】： 福建省中醫(yī)藥研究院;
【基金】：國家自然科學基金面上項目(81373733) 福建省屬公益類科研院所基本科研專項(2015R1035-4)
【分類號】：R245
【正文快照】： 電針療法是通過電針儀實現(xiàn)的,電針儀以電針參數(shù)刺激為主[1-3]。電針參數(shù)中的頻率代表單位時間內(nèi)輸出的電脈沖個數(shù)。根據(jù)頻率組成的差異,目前通用各型電針儀的輸出波型有連續(xù)波、疏密波和斷續(xù)波3種[4-5]。連續(xù)波是指頻率為一固定值的脈沖串;疏密波是指兩頻率交替的脈沖串;斷續(xù)

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