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非酒精性脂肪肝中醫(yī)證型分布及其與客觀指標(biāo)的相關(guān)性調(diào)查

發(fā)布時(shí)間:2018-01-30 02:28

  本文關(guān)鍵詞: 非酒精性脂肪肝 中醫(yī)證型 客觀指標(biāo) 相關(guān)性 出處:《成都中醫(yī)藥大學(xué)》2016年碩士論文 論文類型:學(xué)位論文


【摘要】:目的:調(diào)查非酒精性脂肪肝患者的中醫(yī)證型分布,探索年齡、性別、BMI、肝功能、血糖、血脂指標(biāo)與中醫(yī)證型的相關(guān)性,為NAFLD患者的中醫(yī)辨證治療提供參考。方法:納入就診于成都中醫(yī)藥大學(xué)消化科、內(nèi)分泌門診及體檢中心,符合診斷標(biāo)準(zhǔn)的單純性非酒精性脂肪肝患者301例,采用統(tǒng)一的量化表格,進(jìn)行流行病學(xué)調(diào)查問卷,采集中醫(yī)四診辨別證候,記錄客觀指標(biāo),使用SPSS19.0統(tǒng)計(jì)軟件分析中醫(yī)證型分布,比較各證型與年齡、性別、BMI、肝功、血脂、血糖等指標(biāo)的相關(guān)性,并使用SAS9.3軟件進(jìn)行多重logistic回歸分析。結(jié)果:1、301例NAFLD患者中,證型以肝郁脾虛證最多,占26.92%,其他依次為:痰濕內(nèi)阻證(25.57%)、濕熱蘊(yùn)結(jié)證(22.92%)、肝郁氣滯證(17.94%)、痰瘀互結(jié)證(5.65%);2、性別與中醫(yī)證型分布有統(tǒng)計(jì)學(xué)差異(P0.05),男性以濕熱蘊(yùn)結(jié)證及痰濕內(nèi)阻證多見,女性以肝郁脾虛證及肝郁氣滯證多見;3、不同年齡段中醫(yī)證型分布有統(tǒng)計(jì)學(xué)差異(P0.05),青年組以濕熱蘊(yùn)結(jié)證多見,中年組以痰濕內(nèi)阻證多見,老年組以肝郁脾虛及痰瘀互結(jié)證多見;4、腦力勞動(dòng)者占59.14%,體力勞動(dòng)者占40.86%,腦力勞動(dòng)者發(fā)病率高于體力勞動(dòng)者;5、病程與中醫(yī)證型分布差異有統(tǒng)計(jì)學(xué)意義,其中病程1年者以痰濕內(nèi)阻證最多見,病程1-5年者以濕熱蘊(yùn)結(jié)證最多見;6、BMI與中醫(yī)證型分布有統(tǒng)計(jì)學(xué)差異(P0.05),痰濕內(nèi)阻證BMI升高最明顯;7、A/G、ALT、AST、FBG與中醫(yī)證型分布有統(tǒng)計(jì)學(xué)差異(P0.05),以濕熱蘊(yùn)結(jié)證升高明顯。TP、ALB、GLO、AKP、GGT、TBIL、DBIL、 IBIL、TC、TG、HDL-C、LDL-C與中醫(yī)證型分布無統(tǒng)計(jì)學(xué)差異(P0.05);8、血脂各指標(biāo)與中醫(yī)證型無統(tǒng)計(jì)學(xué)差異(P0.05); 9、logistic回歸分析顯示性別、年齡、BMI及FBG是NAFLD中醫(yī)辨證分型的相關(guān)因素。結(jié)論:1、非酒精性脂肪肝患者中醫(yī)辨證分型以肝郁脾虛證最多見;2、男性以濕熱蘊(yùn)結(jié)證及痰濕內(nèi)阻證多見,女性以肝郁脾虛證及肝郁氣滯證多見;青中年以濕熱內(nèi)蘊(yùn)及痰濕內(nèi)阻證最常見,老年人以肝郁脾虛證及痰瘀互結(jié)證最常見;痰濕內(nèi)阻證BMI升高最明顯;濕熱蘊(yùn)結(jié)證中A/G、ALT、AST、FBG普遍升高明顯;3、logistic回歸分析顯示性別、年齡、BMI及FBG是NAFLD辨證分型的獨(dú)立相關(guān)因素。
[Abstract]:Objective: TCM syndromes in patients with alcoholic fatty liver distribution, non investigation on age, gender, BMI, liver function, blood glucose, blood lipid indexes and the correlation between TCM syndrome type, provide a reference for TCM treatment of NAFLD patients. Methods: patients treated at the Chengdu University of Traditional Chinese Medicine Department of digestion, endocrine clinic and medical examination center, diagnosis the standard of simple nonalcoholic fatty liver patients with 301 cases, using the uniform quantization table, epidemiological survey questionnaire, collecting TCM Differentiation Syndromes, recording objective index, using SPSS19.0 statistical software to analyze the distribution of TCM syndromes, the syndrome type and age, gender, BMI, liver function, blood lipid, blood glucose and other correlation the index, and multiple logistic regression analysis using SAS9.3 software. Results: 1301 cases of patients with NAFLD syndrome, to stagnation and spleen deficiency, accounting for 26.92% of the other, according to the times: phlegm (25.57%) Rdhs (22.92%), (17.94%), qi stagnation, phlegm and blood stasis (5.65%); 2, gender and the distribution of TCM syndromes have significant difference (P0.05), male rdhs and phlegm dampness syndrome, women with stagnation of liver qi stagnation and spleen deficiency syndrome and see; 3, different age distribution of TCM syndromes have significant difference (P0.05) in the young group, rdhs rare, middle-aged group with phlegm dampness syndrome in the elderly group, liver stagnation and spleen deficiency and phlegm and blood stasis see; 4, mental workers accounted for 59.14%, manual workers accounted for 40.86%, the incidence of mental workers the rate is higher than that of manual workers; 5, the course of disease and TCM syndrome type distribution difference was statistically significant, the most common of which 1 years duration with phlegm, the most common course of 1-5 years to rdhs; 6, BMI with the distribution of TCM syndromes have significant difference (P0.05), phlegm BMI increased obviously; 7, A/G, ALT,AST,FBG涓庝腑鍖昏瘉鍨嬪垎甯冩湁緇熻瀛﹀樊寮,

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