本文關(guān)鍵詞： 潰瘍性結(jié)腸炎 潰結(jié)靈Ⅳ號(hào) 保留灌腸 低氧誘導(dǎo)因子 乳鐵蛋白　出處：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：潰瘍性結(jié)腸炎(ulcerative colitis,UC)是一種慢性非特異性腸道疾病,具體致病因素不明確。目前醫(yī)學(xué)界普遍認(rèn)為UC的發(fā)病是由家族遺傳、免疫調(diào)節(jié)、環(huán)境等各種因素共同導(dǎo)致的。主要以腹痛、腹瀉、粘液膿血便為主。病變部位主要局限在結(jié)直腸的粘膜層和粘膜下層,彌漫性分布,主要集中在直腸、乙狀結(jié)腸為主。UC在歐美遠(yuǎn)高于發(fā)病率國(guó)內(nèi),但近些年在我國(guó)也有明顯的遞增趨勢(shì)。在治療方面,西醫(yī)主要以5-氨基水楊酸、糖皮質(zhì)激素、免疫抑制劑為主,最近幾年出現(xiàn)了一類(lèi)新的藥物——生物制劑,能提供更加有效的靶向治療。鑒于西藥長(zhǎng)期使用帶來(lái)的副作用以及治療成本的居高不下,中醫(yī)藥治療UC另辟蹊徑,不僅在UC癥狀緩解方面取得了顯著的療效,而且為患者節(jié)約了客觀的經(jīng)濟(jì)支出,發(fā)揮了中藥便捷、廉價(jià)、有效的優(yōu)勢(shì)。這也為我們進(jìn)一步研究探索中醫(yī)中藥治療UC帶來(lái)了信心。目的:探討潰結(jié)靈Ⅳ號(hào)對(duì)大腸濕熱型UC活動(dòng)期患者的療效。方法:將符合大腸濕熱型活動(dòng)期UC診斷標(biāo)準(zhǔn)的30例患者隨機(jī)分成治療組(15例)和對(duì)照組(15例)。治療組和對(duì)照組分別采用潰結(jié)靈Ⅳ號(hào)和美沙拉嗪保留灌腸,早晚各一次,一個(gè)療程為7天,連續(xù)4療程。觀察治療組與對(duì)照組中患者血清HIF-1 α和糞便LF含量變化水平,以此指標(biāo)評(píng)估潰結(jié)靈Ⅳ號(hào)和美沙拉嗪療效對(duì)比,為臨床使用結(jié)靈Ⅳ號(hào)提供可靠依據(jù)。結(jié)果:治療前后治療組、對(duì)照組的血清HIF-1α和糞便LF含量均有明顯降低。其中,治療組血清HIF-1 α治療前(85.65 ± 11.16)ng/L,治療后(41.52± 9.57)ng/L,變化率(44.13± 12.79)ng/L,P0.05。對(duì)照組血清HIF-1α治療前(86.84±12.05)ng/L,治療后(52.27 ±10.19)ng/L,變化率(34.57±11.68)ng/L,P0.05。治療組糞便LF治療前(94.93 ± 17.41)ng/L,治療后(12.21± 2.07)ng/L,變化率(82.71±16.65)ng/L,P0.05。對(duì)照組糞便 LF 治療前(92.87± 16.15)ng/L,治療后(12.69± 3.44)ng/L,變化率(80.17±14.55)ng/L,P0.05。治療組的Sutherland、腸鏡評(píng)分與對(duì)照組均有明顯改善。結(jié)論:1.潰結(jié)靈Ⅳ號(hào)對(duì)大腸濕熱型UC活動(dòng)期患者的療效顯著。2.潰結(jié)靈Ⅳ號(hào)可使大腸濕熱型UC活動(dòng)期患者的血清HIF-1 α和糞便LF明顯降低。
[Abstract]:Ulcerative colitis (UCC) is a chronic nonspecific intestinal disease. The specific pathogenic factors are not clear. At present, medical circles generally believe that UC is caused by family heredity, immune regulation, environment and other factors, mainly by abdominal pain, diarrhea. Mucus abscess mainly. The lesion is mainly located in the mucous layer and submucous layer of the colorectal, diffuse distribution, mainly concentrated in the rectum, sigmoid colon mainly in Europe and the United States is much higher than the incidence of domestic. But in recent years, there is an obvious increasing trend in our country. In the treatment, Western medicine is mainly 5-aminosalicylic acid, glucocorticoid, immunosuppressant. In recent years, a new class of medicine-biological agents have appeared. Can provide more effective targeted treatment. In view of the long-term use of Western medicine side effects and high cost of treatment, Chinese medicine treatment UC is a new way. Not only in the relief of UC symptoms achieved a significant effect, but also for patients to save the objective economic expenditure, played a convenient and cheap Chinese medicine. The effective advantage. This also brings confidence for us to further study and explore Chinese medicine to treat UC. Objective: to explore the curative effect of Kuijieling 鈪，

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