本文關(guān)鍵詞： 沙棘 沙棘總黃酮 網(wǎng)絡(luò)藥理學(xué) 心肌缺血 機制研究　出處：《中國中藥雜志》2017年07期 　論文類型：期刊論文

【摘要】：該研究采用網(wǎng)絡(luò)藥理學(xué)虛擬篩選方法,旨在進(jìn)一步研究沙棘總黃酮(total flavonoids of Hippophae rhamnoides,TFH)治療心肌缺血的活性成分和作用機制。首先通過TCMSP數(shù)據(jù)庫和PubChem數(shù)據(jù)庫,結(jié)合口服利用度和類藥性分析,篩選出沙棘化合物中的黃酮類化合物。篩選得到的7個化合物再通過Chem Mapper服務(wù)器進(jìn)行靶點的預(yù)測分析。將得到的潛在靶點導(dǎo)入MAS 3.0數(shù)據(jù)庫,結(jié)合KEGG數(shù)據(jù)庫進(jìn)行靶點分析和通路分析。最后使用Cystoscope 3.3.0軟件繪制"化合物-靶點-作用通路"網(wǎng)絡(luò)圖。虛擬實驗預(yù)測得到了68個潛在靶點和60條信號通路,其中有31個靶點和23條通路直接或間接與心肌缺血有關(guān)。結(jié)果表明,TFH主要通過對鈣離子信號通路(calcium signaling pathway)、血管內(nèi)皮生長因子信號通路(VEGF signaling pathway)和縫隙連接信號通路(gap junction)等信號通路的調(diào)節(jié)發(fā)揮協(xié)同作用,且與文獻(xiàn)報道吻合;提示其可能通過參與調(diào)節(jié)血小板聚集、脂質(zhì)代謝、炎癥反應(yīng)等過程,增強心功能和對血管內(nèi)皮細(xì)胞保護(hù)作用,從而發(fā)揮抗心肌缺血的作用。
[Abstract]:The virtual screening method of network pharmacology was used in this study. Objective to further study the total flavonoids of Hippophae rhamnoides of Hippophae rhamnoides. The active components and the mechanism of action of TFH in the treatment of myocardial ischemia were analyzed by TCMSP database and PubChem database combined with oral availability and drug-like analysis. The flavonoids from Hippophae rhamnoides compounds were screened. 7 compounds were screened and analyzed by Chem Mapper server. The potential targets were imported into MAS. 3.0 Database. In combination with KEGG database, target analysis and path analysis are carried out. Finally, "Compound-target-Action Pathway" is drawn by using Cystoscope 3.3.0 software. Network Diagram. Virtual experiment predicts 68 potential targets and 60 signal pathways. Among them, 31 targets and 23 pathways were directly or indirectly related to myocardial ischemia. TFH mainly through calcium signaling pathway. Vascular endothelial growth factor (VEGF signaling pathway) and gap junction signal pathway (gap junction). The regulation of iso-signal pathway plays a synergistic role. The results were in good agreement with the literature reports. These results suggest that it may play a role in anti-myocardial ischemia by regulating platelet aggregation, lipid metabolism and inflammatory reaction, enhancing cardiac function and protecting vascular endothelial cells.
【作者單位】： 成都中醫(yī)藥大學(xué);
【基金】：國家自然科學(xué)基金面上項目(81473428)
【分類號】：R29
【正文快照】： 心肌缺血(myocardial ischemia),是指心臟的血液灌注減少,導(dǎo)致心臟的供氧減少,心肌能量代謝不正常,不能維持心臟正常工作的一種病理狀態(tài)[1]。冠狀動脈阻塞、主動脈供血減少和血壓降低,可直接導(dǎo)致心臟供血減少;心瓣膜病、血黏度變化和心肌本身病變同樣也會使心臟供血減少。其中

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