本文關(guān)鍵詞：基于“脾虛毒損胃絡(luò)”假說應(yīng)用健脾消毒飲治療慢性萎縮性胃炎癌前病變的臨床研究　出處：《山東中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： CAG 癌前病變 脾虛毒損胃絡(luò) 健脾消毒飲 臨床研究

【摘要】：目的:觀察健脾消毒飲治療慢性萎縮性胃炎癌前病變的臨床療效,并從理論和臨床兩方面探討其作用機(jī)制,為中醫(yī)藥從“毒”論治CAG及胃癌前病變提供新的思路與方法。方法:選擇符合納入標(biāo)準(zhǔn)的CAG癌前病變患者60例,隨機(jī)分為2組,即試驗(yàn)組和對(duì)照組,各30例。試驗(yàn)組給予健脾消毒飲口服治療,日一劑;對(duì)照組給予胃復(fù)春片口服治療,一次4片,一日3次。兩組均以1月為1療程,共3療程。觀察治療前后兩組患者的臨床癥狀、胃鏡象、病理組織學(xué)、幽門螺桿菌、血流變、表皮生長(zhǎng)因子(EGF)等變化情況。結(jié)果:治療結(jié)束后,兩組病例臨床總有效率比較,試驗(yàn)組為90.00%,對(duì)照組為70.00%,差異有統(tǒng)計(jì)學(xué)意義(P0.05);試驗(yàn)組萎縮、腸化及異型增生等病理組織學(xué)積分改善情況明顯優(yōu)于對(duì)照組(P0.05);試驗(yàn)組與對(duì)照組的Hp根除率分別為55.56%、47.37%;兩組EGF表達(dá)情況較前改善(P0.05);兩組血流變情況均較治療前明顯改善(P0.05),且試驗(yàn)組療效更優(yōu)(P0.01)。結(jié)論:基于“脾虛毒損胃絡(luò)”的健脾消毒飲是治療慢性萎縮性胃炎癌前病變的有效方藥。在改善臨床癥狀,阻斷、甚或逆轉(zhuǎn)CAG及胃癌前病變之發(fā)生發(fā)展,具有重要指導(dǎo)意義。
[Abstract]:Objective: to observe the clinical effect of Jianpi xiaoyin in treating precancerous lesions of chronic atrophic gastritis, and to explore its mechanism from both theoretical and clinical aspects. Methods: 60 patients with precancerous lesions of CAG were selected and randomly divided into two groups: experimental group and control group. 30 cases in each group were given oral treatment with Jianpi disinfectant drink once a day. The control group was treated with Weifuchun tablet orally, 4 tablets once, 3 times on 1st. The two groups were treated with January as a course of treatment for 3 courses. The clinical symptoms, gastroscopy and histopathology of the two groups were observed before and after treatment. Results: after the treatment, the total effective rate of the two groups was 90.00%. The control group was 70.00g, the difference was statistically significant (P 0.05). The improvement of histopathological scores such as atrophy, intestinal metaplasia and dysplasia in the experimental group was significantly better than that in the control group (P 0.05). The eradication rate of HP in the test group and the control group was 55.56 and 47.37 respectively. The expression of EGF in the two groups was better than that in the former group. The hemorheology in both groups was significantly improved than that before treatment (P0.05). Conclusion: Jianpi disinfection decoction based on "spleen deficiency and toxin damage stomach collaterals" is an effective prescription for the treatment of precancerous lesions of chronic atrophic gastritis. Even reversing the occurrence and development of CAG and gastric precancerous lesions has important guiding significance.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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