本文關(guān)鍵詞：原明忠滋潛通脈湯對(duì)原發(fā)性高血壓（陰虛陽亢證）Hcy、hs-CRP的影響　出處：《山西中醫(yī)學(xué)院》2016年碩士論文　論文類型：學(xué)位論文

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【摘要】：目的通過觀察原明忠滋潛通脈湯對(duì)原發(fā)性高血壓陰虛陽亢證的臨床療效,探索其降壓機(jī)理及對(duì)血清同型半胱氨酸(Hcy)和高敏C反應(yīng)蛋白(hs-CRP)的作用機(jī)制,為其治療原發(fā)性高血壓陰虛陽亢證提供可靠的臨床依據(jù)。方法選取2014年7月至2015年6月,符合診斷標(biāo)準(zhǔn)、納入標(biāo)準(zhǔn)、排出標(biāo)準(zhǔn)的60例高血壓陰虛陽亢證患者,將60例入選的受試者隨機(jī)分為試驗(yàn)組(30例)和對(duì)照組(30例),兩組的在性別、年齡、體重、體重指數(shù)、病程、中醫(yī)證候、Hcy、hs-CRP等方面均無明顯差異(P0.05)。對(duì)照組給予苯磺酸左旋氨氯地平片(施慧達(dá)),試驗(yàn)組在苯磺酸左旋氨氯地平片(施慧達(dá))基礎(chǔ)上加上原明忠滋潛通脈湯,記錄并比較治療前后患者血壓、中醫(yī)臨床癥狀、Hcy、hs-CRP的變化。結(jié)果在降壓方面:試驗(yàn)組的總有效率(90%)與對(duì)照組總有效率(70%)相比,差異有統(tǒng)計(jì)學(xué)意義(P0.05),說明試驗(yàn)組的降壓效果較對(duì)照組明顯;在臨床療效方面:試驗(yàn)組的有效率(90%)與對(duì)照組的有效率(53.33%)相比,差異有統(tǒng)計(jì)學(xué)意義(P0.05),說明試驗(yàn)組較對(duì)照組對(duì)臨床療效的改善明顯;在Hcy方面:試驗(yàn)組對(duì)Hcy的降低作用較對(duì)照組明顯,差異有統(tǒng)計(jì)學(xué)意義(P0.05);在hs-CRP方面:試驗(yàn)組對(duì)hs-CRP的降低作用較對(duì)照組明顯,差異有統(tǒng)計(jì)學(xué)差異(P0.05)。臨床應(yīng)用滋潛通脈湯過程中,未發(fā)現(xiàn)不良反應(yīng)。結(jié)論滋潛通脈湯在治療陰虛陽亢型高血壓臨床療效確切,對(duì)腰酸、膝軟、五心煩熱、心悸、耳鳴等中醫(yī)臨床癥狀改善明顯,能明顯降低Hcy及hs-CRP水平。
[Abstract]:Objective to observe the clinical curative effect of Yuanmingzhiqian Tongmai decoction on the syndrome of yin deficiency and hyperactivity of yang in essential hypertension. To explore the mechanism of hypotension and its action on serum homocysteine (Hcyl) and Gao Min C-reactive protein (hs-CRP). To provide a reliable clinical basis for the treatment of essential hypertension syndrome of yin deficiency and hyperactivity of yang. Methods selected from July 2014 to June 2015, met the diagnostic criteria and included the criteria. A total of 60 patients with high blood pressure with yin deficiency and yang hyperactivity were randomly divided into two groups: experimental group (n = 30) and control group (n = 30). Sex, age, body weight and body mass index were measured in both groups. There was no significant difference in course of disease and Hcyhs-CRP in TCM syndrome. The control group was treated with levamlodipine benzenesulfonic acid tablets (Shwe Huida). Experimental group on the basis of levamlodipine benzenesulfonic acid tablets (Shwe Da) added Yuanming Zhongzi Qiantongmai decoction to record and compare the blood pressure of patients before and after treatment, Chinese medicine clinical symptoms of Hcy. Results in terms of lowering blood pressure: the total effective rate of the trial group was 90) and the total effective rate of the control group was 70), the difference was statistically significant (P 0.05). The results showed that the antihypertensive effect of the test group was more obvious than that of the control group. In terms of clinical efficacy: the effective rate of the trial group was 90% compared with that of the control group (53.33), the difference was statistically significant (P0.05). The results showed that the clinical effect of the experimental group was better than that of the control group. In terms of Hcy, the decrease of Hcy in the test group was more obvious than that in the control group, and the difference was statistically significant (P 0.05). In the aspect of hs-CRP: the decrease of hs-CRP in the trial group was more obvious than that in the control group, and the difference was statistically significant (P0.05. in the course of clinical application of Ziqian Tongmai decoction. Conclusion Ziqian Tongmai decoction is effective in the treatment of Yin-deficiency and Yang-hyperactivity type hypertension. It can improve the clinical symptoms of TCM such as lumbar acid, soft knee, five upset heat, palpitation, tinnitus and so on. The levels of Hcy and hs-CRP were significantly decreased.
【學(xué)位授予單位】：山西中醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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