本文關(guān)鍵詞：胸痹痰阻心脈證和陰寒凝滯證與CYP2C19基因代謝型分布相關(guān)性研究　出處：《南京中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

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【摘要】：目的：研究胸痹痰阻心脈證及陰寒凝滯證患者CYP2C19基因代謝型分布特點(diǎn),并探索兩組中醫(yī)證型與基因代謝型之間的相關(guān)性。方法：通過(guò)對(duì)2015年5月-2016年1月期間,江蘇省中醫(yī)院心內(nèi)科住院病人進(jìn)行中醫(yī)辨證分型,共收集符合中西醫(yī)診斷標(biāo)準(zhǔn)的患者169例。住院期間測(cè)定其CYP2C19基因型及相關(guān)實(shí)驗(yàn)室指標(biāo),并將患者的檢查結(jié)果、病史資料、基本信息等記錄在臨床資料信息收集表中。待研究結(jié)束時(shí),對(duì)相關(guān)數(shù)據(jù)進(jìn)行整理歸納,并用SPASS軟件處理,分析出胸痹痰阻心脈證及陰寒凝滯證患者CYP2C19基因代謝型分布特點(diǎn),以及兩組中醫(yī)證型與基因代謝型之間的相關(guān)性。結(jié)果：169例病人中CYP2C19基因代謝型分布：快代謝68例(40.2%)、中等代謝79例(46.8%)、慢代謝22例(13%)�？齑x在痰阻心脈證中所占比例為44.1%,在陰寒凝滯證中所占比例為19.2%,兩者之間的分布差異具有統(tǒng)計(jì)學(xué)價(jià)值(P=0.0180.05),更傾向于在痰阻心脈證中表達(dá)；中等代謝型在痰阻心脈證中所占比例為42.7%,在陰寒凝滯證中所占比例為69.2%,兩者之間的分布差異具有統(tǒng)計(jì)學(xué)價(jià)值(P=0.0120.05),更傾向于在陰寒凝滯證中表達(dá)。結(jié)論：CYP2C19基因代謝型以快代謝和中等代謝為主；痰阻心脈證與陰寒凝滯證及CYP2C19基因代謝型存在相關(guān)性,快代謝更傾向于在痰阻心脈證中表達(dá),中等代謝更傾向于在陰寒凝滯證中表達(dá),其內(nèi)在機(jī)制尚需進(jìn)一步研究。
[Abstract]:Objective: to study the distribution characteristics of CYP2C19 gene metabolic type in patients with syndrome of phlegm obstruction of heart pulse and syndrome of Yin cold stagnation. And to explore the two groups of TCM syndromes and gene metabolism type correlation. Methods: from May 2015 to January 2016, Jiangsu Provincial Hospital of traditional Chinese Medicine, Department of Cardiology inpatients were classified by TCM syndrome differentiation. A total of 169 patients who met the diagnostic criteria of traditional Chinese and western medicine were collected and their CYP2C19 genotypes and related laboratory indexes were determined during hospitalization. The examination results and medical history of the patients were also analyzed. The basic information was recorded in the clinical information collection table. At the end of the study, the related data were summarized and processed with SPASS software. To analyze the distribution characteristics of CYP2C19 gene metabolism in patients with syndrome of phlegm obstruction of heart pulse and syndrome of Yin cold stagnation. Results the distribution of CYP2C19 gene metabolic type in 169 cases: fast metabolism 68 cases 40.2%). There were 79 cases of moderate metabolism and 22 cases of slow metabolism. The proportion of fast metabolism in phlegm blocking heart pulse syndrome was 44.1, and that in Yin cold stagnation syndrome was 19.2%. The difference of distribution between the two groups has statistical value. It is more likely to be expressed in phlegm blocking heart and pulse syndrome. The proportion of moderate metabolic type in phlegm blocking heart vein syndrome was 42.7 and that in Yin cold stagnation syndrome was 69.2%. The distribution difference between the two has statistical value (P0.0120.05). Conclusion the metabolic type of CYP2C19 gene is mainly fast metabolism and moderate metabolism. There was a correlation between phlegm blocking heart pulse syndrome and Yin cold stagnation syndrome and metabolism type of CYP2C19 gene. Fast metabolism was more inclined to express in phlegm blocking heart vein syndrome and moderate metabolism was more inclined to express in Yin cold stagnation syndrome. Its internal mechanism needs further study.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R256.22

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