本文關(guān)鍵詞：毫火針治療白癜風(fēng)多中心隨機(jī)對照開放式優(yōu)效性研究　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 毫火針 白癜風(fēng) 0.1%他克莫司軟膏

【摘要】：目的:通過觀察毫火針治療白癜風(fēng)的臨床療效和不良反應(yīng),來驗(yàn)證毫火針治療白癜風(fēng)的有效性及安全性。方法:采用計(jì)算機(jī)簡單隨機(jī)法,將40例白癜風(fēng)患者分為兩組:試驗(yàn)組20人,對照組20人,試驗(yàn)組外用0.1%他克莫司軟膏聯(lián)合毫火針治療,對照組單純外用0.1%他克莫司軟膏,分別在治療后4、8、12周進(jìn)行療效評價(jià)。治療結(jié)束后隨訪1月。結(jié)果:對照組完成19例,試驗(yàn)組完成18例。首先,面積比較:治療4、8、12周時(shí),兩組間白斑面積比較均采用獨(dú)立樣本t檢驗(yàn),差異均無統(tǒng)計(jì)學(xué)意義(P0.05);在對照組、試驗(yàn)組中,治療前與治療4、8、12周,白斑面積比較均采用配對t檢驗(yàn),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。其次,療效比較:對照組中,治療4周,顯效0例,好轉(zhuǎn)8例,無效11例,顯效率0,有效率42.000%;治療8周,顯效1例,好轉(zhuǎn)12例,無效6例,顯效率5.263%,有效率68.421%;治療12周,顯效3例,好轉(zhuǎn)10例,無效6例,顯效率15.789%,有效率68.421%。試驗(yàn)組中,治療4周,顯效2例,好轉(zhuǎn)9例,無效7例,顯效率11.111%,有效率61.111%;治療8周,顯效3例,好轉(zhuǎn)14例,無效1例,顯效率16.667%,有效率94.444%;治療12周,顯效6例,好轉(zhuǎn)11例,無效1例,顯效率33.333%,有效率94.444%。治療4周,兩組療效比較采用秩和檢驗(yàn),差異無統(tǒng)計(jì)學(xué)(P0.05);治療8、12周,兩組療效比較均采用了秩和檢驗(yàn),差異有統(tǒng)計(jì)學(xué)(P0.05)。最后,皮膚CT結(jié)果比較:經(jīng)12周治療后,試驗(yàn)組皮膚CT黑素細(xì)胞變化率為72.222%,對照組皮膚CT黑素細(xì)胞變化率為31.579%,兩組皮膚CT結(jié)果比較經(jīng)確切概率法檢驗(yàn),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:毫火針聯(lián)合外用0.1%他克莫司軟膏與單獨(dú)外用0.1%他克莫司軟膏治療白癜風(fēng)疾病均有一定療效,毫火針聯(lián)合外用0.1%他克莫司軟膏較單獨(dú)外用0.1%他克莫司軟膏治療白癜風(fēng)疾病療效更顯著。然而,毫火針治療白癜風(fēng)的具體療效有待進(jìn)一步探究。
[Abstract]:Objective: to evaluate the efficacy and safety of neufire acupuncture in the treatment of vitiligo by observing the clinical efficacy and adverse reactions. Methods: a simple computer method was used to treat vitiligo. Forty patients with vitiligo were divided into two groups: experimental group (n = 20) and control group (n = 20). The experimental group was treated with 0.1% tacrolimus ointment combined with needling needle, and the control group was treated with 0.1% tacrolimus ointment. Results: 19 cases in control group and 18 cases in test group. First, area comparison: at 12 weeks after treatment, the area was compared: at 12 weeks after treatment, 19 cases were completed in the control group and 18 cases in the experimental group. First, the area comparison: at 12 weeks after treatment, 19 cases were completed in the control group and 18 cases in the experimental group. The white spot area of the two groups were compared by independent sample t test, and the difference was not statistically significant (P 0.05). In the control group, the experimental group, before treatment and treatment for 8 weeks 12 weeks, the white spot area was compared by paired t test, the difference was statistically significant (P 0.05). Second, comparison of efficacy: in the control group. After 4 weeks of treatment, there were significant effects in 0 cases, improvement in 8 cases, ineffective in 11 cases, marked rate of 0 and effective rate of 42,000; After 8 weeks of treatment, there were 1 case of remarkable effect, 12 cases of improvement and 6 cases of ineffectiveness. The effective rate was 5.263 and the effective rate was 68.421. After 12 weeks of treatment, there were 3 cases of marked effect, 10 cases of improvement, 6 cases of ineffectiveness, 15.789% of effective rate and 68.421% of effective rate. In the experimental group, there were 2 cases of remarkable effect, 9 cases of improvement and 7 cases of ineffectiveness. The effective rate is 11.111 and the effective rate is 61.111; After 8 weeks of treatment, there were 3 cases of remarkable effect, 14 cases of improvement and 1 case of ineffectiveness. The effective rate was 16.667% and the effective rate was 94.444%. After 12 weeks of treatment, there were 6 cases of marked effect, 11 cases of improvement, 1 case of ineffectiveness, 33.333% of marked rate and 94.4444% of effective rate. For 4 weeks, the curative effect of the two groups was compared by rank sum test. The difference was not significant (P 0.05). After 812 weeks of treatment, the two groups were treated with rank sum test, and the difference was statistically significant (P 0.05). Finally, the results of skin CT were compared: after 12 weeks of treatment. The change rate of CT melanocytes in the experimental group was 72.222 and that in the control group was 31.579.The results of CT in the two groups were compared by the exact probability method. Conclusion: the combination of 0.1% tacrolimus ointment and 0.1% tacrolimus ointment is effective in the treatment of vitiligo. 0.1% tacrolimus ointment was more effective than 0.1% tacrolimus ointment alone in the treatment of vitiligo.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R246.7

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