本文關(guān)鍵詞：青石止癢軟膏聯(lián)合消風(fēng)止癢湯加減治療神經(jīng)性皮炎的療效評(píng)價(jià)　出處：《中國(guó)實(shí)驗(yàn)方劑學(xué)雜志》2017年21期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 神經(jīng)性皮炎 消風(fēng)止癢湯 青石止癢軟膏 瘙癢介質(zhì) 炎癥因子

【摘要】：目的:觀察青石止癢軟膏聯(lián)合消風(fēng)止癢湯加減辨證治療神經(jīng)性皮炎的臨床療效,及對(duì)瘙癢介質(zhì)和炎癥因子的影響。方法:將160例患者隨機(jī)按數(shù)字表法分為西醫(yī)組和中醫(yī)組各80例。西醫(yī)組外用糠酸莫米松乳膏,均勻涂于患處,每天早晚各1次;口服氯雷他定片,10 mg/次,1次/d。中醫(yī)組外用青石止癢軟膏,將藥物輕揉于患處,每天早晚各1次;內(nèi)服消風(fēng)止癢湯加減,1劑/d,兩組療程均為21 d。進(jìn)行治療前后瘙癢程度采用視覺(jué)模擬評(píng)分(VAS),皮損程度采用濕疹面積及嚴(yán)重度指數(shù)(EASI)評(píng)分,中醫(yī)證候評(píng)分,生活質(zhì)量采用皮膚病生活質(zhì)量(DIQL)量表評(píng)價(jià),檢測(cè)治療前后5-羥色胺(5-HT),組胺,P物質(zhì)(SP),β-內(nèi)啡肽(β-EP),白細(xì)胞介素-6(IL-6),IL-8和腫瘤壞死因子-α(TNF-α)水平。結(jié)果:中醫(yī)組臨床療效總有效率為95.95%,高于西醫(yī)組的84.93%(χ~2=5.173,P0.05);中醫(yī)組中醫(yī)證候療效總有效率為95.95%,高于西醫(yī)組的78.08%(χ2=10.419,P0.01);治療后中醫(yī)組患者的瘙癢VAS,EASI,中醫(yī)證候和DIQL評(píng)分均低于西醫(yī)組(P0.01);治療后中醫(yī)組5-HT,組胺,SP,β-EP水平均低于西醫(yī)組(P0.01);治療后中醫(yī)組IL-6,IL-8和TNF-α水平均低于西醫(yī)組(P0.01)。結(jié)論:與西醫(yī)常規(guī)治療方案相比較,采用消風(fēng)止癢湯加減內(nèi)服聯(lián)合青石止癢軟膏外用治療神經(jīng)性皮炎能減輕患者瘙癢,改善皮損癥狀,降低中醫(yī)證候評(píng)分,提高患者的生活質(zhì)量,能調(diào)節(jié)引起瘙癢的化學(xué)介質(zhì)和免疫炎癥因子,臨床療效和中醫(yī)證候療效均優(yōu)于西醫(yī)常規(guī)療法。
[Abstract]:Objective: to observe the clinical effect of Qingshi Zhiyang ointment combined with Xiaofeng Zhiyang decoction on neurodermatitis. Methods: 160 patients were randomly divided into western medicine group (n = 80) and traditional Chinese medicine group (n = 80). 1 time in the morning and evening; Oral Loratadine 10 mg / time 1 / d. Chinese medicine group external use of Qingshi antipruritic ointment, the drug gently rubbed in the affected area, once a day in the morning and evening; Oral administration of Xiaofengzhi itching decoction 1 / d, the two courses of treatment were 21 days. The degree of pruritus before and after treatment was assessed by visual analogue score (VASS). Eczema area and severity index (EASI), TCM syndrome score and quality of life (QOL) were used to evaluate the degree of skin lesions. Before and after treatment, serotonin 5-HT, histamine substance P, 尾 -endorphin (尾 -EPN) and interleukin-6 (IL-6) were detected. Results: the total effective rate of TCM group was 95.95, which was higher than that of western medicine group (84.93%, 蠂 2, 5.173). P0.05; The total effective rate of TCM syndromes in TCM group was 95.95, which was higher than 78.08 in Western medicine group (蠂 2 10.419 P 0.01). After treatment, the pruritus of patients in the TCM group was lower than that in the western medicine group (P 0.01), and the scores of TCM syndromes and DIQL were lower than those in the western medicine group. After treatment, the levels of 5-HT, histamine SPand 尾 -EP in TCM group were lower than those in western medicine group (P 0.01). After treatment, the levels of IL-6, IL-8 and TNF- 偽 in TCM group were lower than those in western medicine group (P 0.01). The treatment of neurodermatitis with Xiaofengzhi itching decoction combined with Qingshi Zhiyang ointment can reduce the pruritus, improve the symptom of skin lesion, reduce the score of TCM syndrome, and improve the quality of life of the patients. It can regulate the chemical mediators and immune inflammatory factors that cause pruritus. The clinical curative effect and TCM syndromes effect are better than that of western medicine routine therapy.
【作者單位】： 北京中醫(yī)藥大學(xué)東方醫(yī)院;
【基金】：北京市科技計(jì)劃課題項(xiàng)目(Z131100002513013)
【分類(lèi)號(hào)】：R275.9
【正文快照】： [網(wǎng)絡(luò)出版地址]http://kns.cnki.net/kcms/detail/11.3495.R.20170809.1125.040.html[網(wǎng)絡(luò)出版時(shí)間]2017-08-09 11:25神經(jīng)性皮炎(neurodermatitis)也稱(chēng)慢性單純性苔蘚,以陣發(fā)性劇烈瘙癢和皮膚苔蘚樣變?yōu)樘卣鞯念B固性慢性炎性皮膚病,皮損局限性或泛發(fā)性。其治療棘手,病情反復(fù)難

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