本文關(guān)鍵詞：原發(fā)性干燥綜合征患者疲勞及相關(guān)因素的橫斷面調(diào)查　出處：《遼寧中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

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【摘要】：目的:調(diào)查原發(fā)性干燥綜合征患者疲勞概況,分析患者疲勞癥狀的相關(guān)因素,間接尋找疲勞的病因線索,為其防治提供臨床依據(jù)。資料與方法:采用橫斷面調(diào)查方法,于2016年1月至2016年3月期間,在遼寧中醫(yī)藥大附屬醫(yī)院風(fēng)濕科門診通過隨機抽樣,對95名符合2002年干燥綜合征國際分類(診斷)標(biāo)準(zhǔn)的原發(fā)性干燥綜合征患者進行問卷調(diào)查。調(diào)查方式為面訪及電話采訪。內(nèi)容包括:一般資料、臨床特征及國內(nèi)外公認(rèn)量表評分(疲勞程度量表、視覺模擬量表、疲勞概況量表,流調(diào)用抑郁量表)。統(tǒng)計方法應(yīng)用SPSS17.0建立數(shù)據(jù)庫,采用t檢驗、卡方檢驗、Logistic回歸分析、偏相關(guān)系數(shù)及多重線性回歸分析等方法;P0.05為差異有統(tǒng)計學(xué)意義。結(jié)果:1.將FSS得分≥4定義為疲勞組,FSS得分4為非疲勞組。p SS相關(guān)性疲勞的發(fā)生率為44.2%。疲勞組患者CES-D評分、CRP、Ig G、C3均高于非疲勞組(P0.05)。2.單因素分析顯示,性別、居住地、受教育程度等因素與p SS相關(guān)性疲勞的發(fā)生無關(guān)(P0.05);Logistic回歸分析顯示,p SS相關(guān)性疲勞與Ig G(OR 1.419[95%CI1.108-1.817])、抑郁情緒(OR 1.162[95%CI 1.047-1.290])、病程(OR 1.019[95%CI1.004-1.034])相關(guān)。3.95名p SS患者疲勞程度的偏相關(guān)分析顯示,CES-D評分與各疲勞量表評分皆具有相關(guān)性。此外,Ig M、Ig A、Ig G等因素分別與FSS、VAS、Pro F、Pro F-S評分相關(guān)(P0.05)。多重線性回歸分析顯示,每組自變量對各疲勞量表評分變異的貢獻分別為FSS(22.5%)、VAS(17.0%)、Pro F-S(48.7%)、Pro F-M(21.5%)。結(jié)論:Ig G水平增高、抑郁情緒加重、病程的延長均可使p SS相關(guān)性疲勞的發(fā)生風(fēng)險增高;抑郁情緒可能為p SS患者疲勞程度的影響因素之一。因橫斷面調(diào)查有其局限性,故進一步尋找可能誘發(fā)疲勞的身心因素及病理機制,對臨床有效緩解p SS患者疲勞癥狀有指導(dǎo)意義。
[Abstract]:Objective: To investigate patients with primary Sjogren syndrome fatigue related factors of fatigue symptoms, indirect search for clues to the etiology of fatigue, and provide clinical basis for its prevention and treatment. Materials and methods: a cross-sectional survey method, during the period from January 2016 to March 2016, in the Liaoning traditional Chinese medicine hospital outpatient department of rheumatism by random sampling, the 95 2002 with Sjogren syndrome (diagnosis) standard international classification of primary Sjogren syndrome patients were surveyed. The survey for the interview and telephone interview. The contents include: general data, clinical features and recognized at home and abroad scale (fatigue severity scale, visual analogue scale, general fatigue scale call flow, depression scale). The application of SPSS17.0 statistical methods to establish a database, using t test, chi square test, Logistic regression analysis, partial correlation coefficient and multiple linear regression analysis method; P0.05 the difference was statistically significant. Results: 1. the FSS score greater than 4 was defined as the fatigue group, FSS score of 4 for non fatigue group.P SS correlation between the incidence of fatigue for 44.2%. fatigue of patients with CES-D score, CRP, Ig, G, C3 were higher than those in non fatigue group (P0.05).2. univariate analysis showed that sex, residence, education and other factors and P SS correlation between the occurrence of fatigue independent (P0.05); Logistic regression analysis showed that P SS and Ig G related fatigue (OR 1.419[95%CI1.108-1.817]), depression (OR 1.162[95%CI 1.047-1.290]), duration (OR 1.019[95% CI1.004-1.034]).3.95 P partial correlation analysis showed the degree of fatigue in patients with SS the CES-D score, and the scores are associated with fatigue. In addition, Ig M, Ig A, Ig G and other factors respectively to FSS, VAS, Pro F, Pro F-S score (P0.05). Multiple linear regression analysis showed that each variable on the fatigue scale variation The contributions were FSS (22.5%), VAS (17%), Pro F-S (48.7%), Pro F-M (21.5%). Conclusion: Ig increased the level of G, increase the duration of depression, can make the P SS correlation between the occurrence of fatigue increased risk; depression may be one of the influencing factors of P SS patients with fatigue because the cross-sectional survey has its limitations, so further search for possible physical and mental factors induced fatigue and pathological mechanism, to effectively alleviate the clinical significance of P SS in patients with symptoms of fatigue.

【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259
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本文編號：1387811