本文關(guān)鍵詞：糖肝煎聯(lián)合電針治療肝郁脾虛、濕熱蘊(yùn)結(jié)型單純性肥胖的臨床療效觀察　出處：《湖北中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 單純性肥胖癥 糖肝煎 電針 改善脂代謝 減輕體重

【摘要】：研究目的:通過觀察糖肝煎聯(lián)合電針對(duì)肝郁脾虛、濕熱蘊(yùn)結(jié)型單純性肥胖癥患者的臨床癥狀積分、腰圍、體重、BMI、腰臀比、甘油三脂、總膽固醇、低密度脂蛋白、高密度脂蛋白等相關(guān)指標(biāo)的影響,以及三大常規(guī)、肝腎功能等變化情況,探討糖肝煎聯(lián)合電針治療肥胖癥(肝郁脾虛、濕熱蘊(yùn)結(jié)證)的臨床療效和安全性。研究方法:采用完全隨機(jī)設(shè)計(jì),將受試對(duì)象按就診順序編號(hào),利用隨機(jī)數(shù)字表分為糖肝煎組、糖肝煎聯(lián)合電針治療組。兩組在同時(shí)給予飲食運(yùn)動(dòng)控制的基礎(chǔ)上,糖肝煎組給予中藥湯劑糖肝煎,1劑/日,分2次口服;糖肝煎聯(lián)合電針組在給予中藥湯劑糖肝煎的同時(shí)給予指定穴位行電針治療,電針治療隔日一次,3個(gè)月為一療程。每2周隨訪一次,進(jìn)行一般體格檢查,記錄臨床癥狀表現(xiàn),觀察兩組治療前后的臨床療效(總有效率)、癥狀積分、體重、BMI、腰圍、腰臀比、甘油三脂、總膽固醇、低密度脂蛋白、高密度脂蛋白等指標(biāo)的變化,以及三大常規(guī)、肝腎功能等變化情況,以評(píng)價(jià)本方法的臨床療效和安全性。研究結(jié)果:本研究共入組60人,因個(gè)人原因中斷治療,或醫(yī)從性差,或聯(lián)系方式虛假,共剔除5例,最終糖肝煎組28例,糖肝煎聯(lián)合電針組27例。在研究前,通過統(tǒng)計(jì)學(xué)分析,發(fā)現(xiàn)糖肝煎組及糖肝煎聯(lián)合電針組兩組之間的患者各方面數(shù)據(jù),包括性別、年齡、身高、體重、腰圍、腰臀比、BMI、中醫(yī)癥狀積分以及血脂全套等各項(xiàng)指標(biāo)組與組之間的差異無統(tǒng)計(jì)學(xué)意義(P0.05),具有可比性。經(jīng)過2個(gè)療程的治療后,⑴從臨床治療總效果來看,糖肝煎組總有效率達(dá)89.29%;糖肝煎聯(lián)合電針組總有效率為96.30%(P0.05),差別有統(tǒng)計(jì)學(xué)意義。⑵兩組患者的癥狀積分在治療后均有所降低(P0.01),糖肝煎聯(lián)合電針組分值更低于糖肝煎組(P0.01),差別有統(tǒng)計(jì)學(xué)意義,提示運(yùn)用糖肝煎聯(lián)合電針治療肥胖癥可有效減輕患者的臨床不適癥狀,提高生活質(zhì)量。⑶兩組治療后腰圍、體重、BMI、腰臀比與治療前相比,有明顯的改善,兩者均有顯著性差異(P0.01)。糖肝煎聯(lián)合電針組指標(biāo)下降程度明顯大于糖肝煎組(P0.01或P0.05)。⑷兩組治療后血脂全套指標(biāo)(TC、TG、HDL、LDL)數(shù)值均有所改善(P0.01),差別有統(tǒng)計(jì)學(xué)意義,將兩組組間差值進(jìn)行比較,并無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論糖肝煎聯(lián)合電針治療單純性肥胖具有較好的臨床療效。其在臨床總療效及改善臨床癥狀上明顯優(yōu)于糖肝煎組,能有效的緩解多種肥胖導(dǎo)致的臨床不適癥狀,明顯提高患者生活質(zhì)量,并能有效的改善脂代謝。整個(gè)研究過程中未見明顯的毒副作用,具有綠色、環(huán)保、無毒副作用的中醫(yī)特色,彰顯了中醫(yī)辨證論治、整體觀念的治療法則,對(duì)現(xiàn)代臨床治療單純性肥胖癥提供了新的安全有效的治療手段,有很廣泛的應(yīng)用前景。
[Abstract]:Objective: to observe the clinical symptom score, waist circumference, body weight, BMIs, waist-to-hip ratio, triglyceride, total cholesterol in patients with simple obesity with liver stagnation and spleen deficiency and damp-heat accumulation. The effects of low density lipoprotein, high density lipoprotein and other related indexes, as well as the changes of three major routine, liver and kidney function, etc., in order to explore the treatment of obesity (liver stagnation and spleen deficiency) with the combination of Tanggan decoction and electroacupuncture. The clinical efficacy and safety of dampness and heat accumulation syndrome). Methods: totally random design was adopted, the subjects were numbered according to the order of seeing a doctor, and were divided into Tanggan decoction group by random number table. The two groups were given diet and exercise control at the same time, the two groups were given 1 dose of traditional Chinese medicine decoction sugar liver decoction per day, divided into 2 oral; Tanggan decoction combined with electroacupuncture group was given traditional Chinese medicine decoction Tanggan decoction at the same time given the designated acupoints electroacupuncture treatment, electroacupuncture treatment every other day, 3 months as a course of treatment. Follow up every 2 weeks, general physical examination. The clinical symptoms were recorded and the clinical efficacy (total effective rate, symptom score, body weight, waist circumference, waist-hip ratio, triglyceride, total cholesterol, low density lipoprotein) were observed before and after treatment. The changes of high density lipoprotein and three major routine, liver and kidney function were used to evaluate the clinical efficacy and safety of this method. Results: 60 patients were enrolled in this study. The treatment was interrupted for personal reasons, or the medical treatment was poor, or the way of contact was false, 5 cases were excluded, 28 cases in the final decoction group and 27 cases in the combined electroacupuncture group. Statistical analysis was made before the study. It was found that there were all kinds of data between the two groups, including gender, age, height, weight, waist circumference, waist-to-hip ratio (WHR) and BMI. There was no significant difference in the scores of symptoms and blood lipids between the two groups, which was comparable. After two courses of treatment, there was no significant difference between the two groups. After two courses of treatment, the total effect of clinical treatment was analyzed. The total effective rate of Tanggan decoction group was 89.29; The total effective rate of Tanggan decoction combined with electroacupuncture group was 96.30g / kg P0.05A, the difference was statistically significant. 2. The symptom score of the two groups decreased after treatment (P 0.01). The score of Tanggan decoction combined with electroacupuncture group was lower than that of Tanggan decoction group (P 0.01), the difference was statistically significant, suggesting that the use of Tanggan decoction combined with electroacupuncture treatment of obesity can effectively reduce the clinical symptoms of patients. After treatment, the waist circumference, body weight and waist-to-hip ratio of the two groups were significantly improved compared with those before treatment. There was a significant difference between the two groups (P 0.01). The decrease degree of indexes in the Tanggan decoction combined with electroacupuncture group was significantly higher than that in the Tanggan decoction group (P0.01 or P0.05.4) after treatment, the total blood lipid index of the two groups was higher than that of the control group (P 0.01 or P 0.05.4). The values of TGV HDL and LDL were all improved (P 0.01), the difference was statistically significant, and the difference between the two groups was compared. Conclusion Tanggan decoction combined with electroacupuncture has a better clinical effect on simple obesity. It is superior to Tanggan decoction group in the total clinical efficacy and improvement of clinical symptoms. Can effectively alleviate a variety of obesity caused by clinical symptoms, significantly improve the quality of life of patients, and can effectively improve lipid metabolism. The characteristics of traditional Chinese medicine without toxic side effects highlight the treatment principle of differentiation of symptoms and signs of traditional Chinese medicine and the whole concept of treatment. It provides a new safe and effective treatment method for modern clinical treatment of simple obesity and has a very broad application prospect.
【學(xué)位授予單位】：湖北中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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