本文關(guān)鍵詞：補(bǔ)中助長顆粒治療學(xué)齡前ISS伴厭食癥的療效觀察　出處：《時珍國醫(yī)國藥》2017年05期 　論文類型：期刊論文

  更多相關(guān)文章： 補(bǔ)中助長顆粒 學(xué)齡前期ISS 厭食癥 療效

【摘要】：目的觀察補(bǔ)中助長顆粒治療學(xué)齡前特發(fā)性矮身材(ISS)伴厭食癥的臨床療效。方法將56例學(xué)齡前ISS伴厭食癥患兒隨機(jī)分為觀察組和對照組各28例,觀察組給予補(bǔ)中助長顆粒口服,對照組給予賴氨酸維B12顆�？诜７謩e比較組內(nèi)、組間治療6月、12月患兒身高(H)、身高增長速度(GV)、身高落后標(biāo)準(zhǔn)差(Ht SDS)、體重指數(shù)(BMI)、年齡/骨齡(CA/BA)、預(yù)測成人身高(PAH);比較治療前和治療6月、12月患兒血清胰島素樣生長因子1(IGF-1)、生長激素激發(fā)試驗所得生長激素峰值(GHP)的變化。制定簡易厭食癥候表,比較治療12月后兩組患兒厭食癥狀改善情況。結(jié)果治療期間兩組患兒H、BMI、CA/BA比較無統(tǒng)計學(xué)意義(P0.05)。治療12月后,觀察組GV、PAH高于對照組,觀察組Ht SDS低于對照組,觀察組患兒血清IGF-1高于對照組,二者比較均具有顯著性差異(P0.05);觀察組總有效率高于對照組,二者比較統(tǒng)計學(xué)意義(P0.05)。治療前后兩組患兒GHP比較無統(tǒng)計學(xué)意義(P0.05)。結(jié)論補(bǔ)中助長顆粒在促進(jìn)ISS患兒生長、改善患兒厭食癥狀方面優(yōu)于賴氨酸維B12顆粒,促進(jìn)ISS患兒血清IGF-1的表達(dá)可能是其作用機(jī)制之一。
[Abstract]:Objective to observe the clinical effect of BZF granule in treating preschool idiopathic short stature (ISS) with anorexia. Methods 56 cases of preschool ISS with anorexia were randomly divided into observation group (n = 28) and control group (n = 28). The observation group was given buzhongfen granule and the control group was given lysine vitamin B12 granule. The height of children in June and December were compared. The body mass index (BMI) and age / bone age were measured by Ht SDS, age / bone age, and the height of adults was predicted. The changes of serum insulin-like growth factor (IGF-1) and growth hormone peak value (GHP) in children before treatment and June and December were compared. A simple anorexia table was established. Results during the treatment period, there was no significant difference in BMICA / BA between the two groups (P 0.05). After December, there was no significant difference between the two groups in the improvement of anorexia symptoms. The serum IGF-1 of the observation group was higher than that of the control group (P 0.05), and that of the observation group was higher than that of the control group (P 0.05). The total effective rate in the observation group was higher than that in the control group. There was no significant difference in GHP between the two groups before and after treatment. Conclusion Buzhong fueling granule can promote the growth of ISS children. The improvement of anorexia in children was better than that of lysine vitamin B 12 granules, and promoting the expression of serum IGF-1 in children with ISS might be one of its mechanisms.
【作者單位】： 鄭州市兒童醫(yī)院;河南省中醫(yī)藥研究院;
【基金】：河南省中醫(yī)藥科學(xué)研究專項課題(No.2015ZY02115) 河南省中醫(yī)藥研究專項(No.2015ZY02073) 河南省科技攻關(guān)項目(No.162102310063)
【分類號】：R272
【正文快照】： 特發(fā)性矮身材(Idiopathic short stature,ISS)是指病因不明、不伴有任何潛在病理狀態(tài)的身材矮小,包括家族性矮身材、體質(zhì)性生長及青春期發(fā)育延遲,其特點是患兒身體比例正常,身高低于同種族、同地區(qū)、同性別、同年齡正常兒童的第3百分位數(shù)或減2個標(biāo)準(zhǔn)差[1]。我科在長期的臨床中，

本文編號：1378003