本文關鍵詞：基于濕濁大鼠多臟腑有機陰離子轉(zhuǎn)運肽3a1表達的濕濁轉(zhuǎn)運機制研究　出處：《中華中醫(yī)藥雜志》2017年09期 　論文類型：期刊論文

  更多相關文章： 濕濁轉(zhuǎn)運 臟腑 有機陰離子轉(zhuǎn)運肽a 濕濁 馬兜鈴酸Ⅰ

【摘要】：目的:探討濕濁大鼠各臟腑組織中有機陰離子轉(zhuǎn)運肽(organic anion transporter polypeptide,oatp)3a1m RNA表達的動態(tài)變化在濕濁轉(zhuǎn)運中的機制。方法:將48只大鼠隨機分成正常組、正常+馬兜鈴酸Ⅰ(aristolochic acidⅠ,AA-Ⅰ)5min組、正常+AA-Ⅰ60min組、濕濁組、濕濁+AA-Ⅰ5min組和濕濁+AA-Ⅰ60min組。經(jīng)處理后取各組大鼠肺、胃、肝、脾、腎、大腸和小腸組織,檢測各組織oatp3a1的基因表達。結(jié)果:與正常組比較,濕濁組脾和大腸oatp3a1 m RNA表達下調(diào)(P0.05),濕濁+AA-Ⅰ5min組脾、大腸、肺和胃oatp3a1 m RNA表達下調(diào)(P0.01,P0.05),濕濁+AA-Ⅰ60min組脾、肺和腎oatp3a1 m RNA表達下調(diào)(P0.01,P0.05)。與正常+AA-Ⅰ60min組比較,濕濁+AA-Ⅰ60min組脾、肺、腎和肝oatp3a1 m RNA表達下調(diào)(P0.01,P0.05)。結(jié)論:在濕濁狀態(tài)下多個臟腑在濕濁轉(zhuǎn)運中存在相互協(xié)調(diào)作用,濕濁轉(zhuǎn)運的機制可能是通過上述臟腑調(diào)節(jié)oatp3a1的表達來實現(xiàn)的。
[Abstract]:Objective: to study the organic anion transport peptide anion transporter polypeptide in the viscera of rats with dampness turbidity. Mechanism of dynamic changes of oatp)3a1m RNA expression in wet turbid transport. Methods: 48 rats were randomly divided into normal group. Aristolochic acid 鈪，

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