本文關(guān)鍵詞：清腦益元湯對缺血性中風患者血清BDNF、NGF、VEGF水平的影響　出處：《廣西中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

  更多相關(guān)文章： 清腦益元湯 缺血性中風 腦源性神經(jīng)營養(yǎng)因子(BDNF) 神經(jīng)生長因子(NGF) 血管內(nèi)皮生長因子(VEGF)

【摘要】：目的:探討清腦益元湯治療缺血性中風的臨床療效及其對患者血清腦源性神經(jīng)營養(yǎng)因子(BDNF)、神經(jīng)生長因子(NGF)及血管內(nèi)皮生長因子(VEGF)水平的影響。方法:選取缺血性中風患者60例,按隨機數(shù)字表法隨機分為治療組與對照組,每組30例,對照組予以單純西醫(yī)常規(guī)治療,治療組在對照組基礎上加用清腦益元湯,14天為1個療程,兩組均治療1個療程,治療前后評價兩組神經(jīng)功能缺損評分及中醫(yī)癥候積分,觀察臨床療效及血清BDNF、NGF、VEGF的表達水平。結(jié)果:(1)治療前,兩組神經(jīng)功能缺損評分、中醫(yī)癥狀積分及血清BDNF、NGF、VEGF水平比較,差異均無統(tǒng)計學意義(P0.05);(2)治療組與對照組治療總有效率和中醫(yī)癥候療效總有效率分別為93.3%、75.8%和90%、62.1%,差異有統(tǒng)計學意義(P0.05),其療效明顯優(yōu)于對照組;(3)治療后,兩組神經(jīng)功能缺損評分及中醫(yī)癥候積分均較治療前降低(P均0.01),血清BDNF、NGF、VEGF水平比較均較治療前升高(P均0.01);(4)治療組神經(jīng)功能缺損評分及中醫(yī)癥候積分均明顯低于對照組(P均0.05),血清NGF、BDNF和VEGF水平均顯著高于對照組(P均0.01)。結(jié)論:清腦益元湯能明顯改善缺血性中風患者神經(jīng)功能缺損程度,其機制可能與提高缺血性中風患者血清BDNF、NGF、VEGF水平有關(guān)。
[Abstract]:Objective: to investigate the clinical effect of Qingnao Yiyuan decoction (QNYD) in treating ischemic apoplexy and its effect on serum brain-derived neurotrophic factor (BDNF). Methods: 60 patients with ischemic stroke were randomly divided into treatment group and control group. Each group of 30 cases, the control group was given simple western routine treatment, the treatment group on the basis of the control group plus Qingnao Yiyuan decoction for 14 days as a course of treatment, both groups were treated with a course of treatment. Before and after treatment, the neurological deficit score and TCM symptom score were evaluated, and the clinical efficacy and the expression of serum BDNF NGF FU VEGF were observed. There was no significant difference in neurological deficit score, TCM symptom score and serum level of BDNFN NGF VEGF between the two groups (P 0.05). The total effective rate of treatment group and control group and the total effective rate of TCM symptoms were 93.3% and 90.8%, respectively. The difference was statistically significant (P 0.05). The curative effect was better than that of the control group. After treatment, the neurological impairment score and TCM symptom score in both groups were lower than those before treatment (P 0.01), and serum BDNF NGF was decreased. The level of VEGF was higher than that before treatment (P < 0.01). (4) the scores of nerve function defect and TCM symptom in the treatment group were significantly lower than those in the control group (P < 0.05), and the serum NGF was significantly lower than that in the control group (P < 0.05). The levels of BDNF and VEGF were significantly higher than those of control group (P < 0.01). Conclusion: Qingnao Yiyuan decoction can obviously improve the degree of nerve function defect in patients with ischemic stroke. The mechanism may be related to the increase of serum BDNF-NGF-VEGF level in ischemic stroke patients.
【學位授予單位】：廣西中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R277.7

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