本文關(guān)鍵詞：探“先天、后天”理論在促進(jìn)去卵巢小鼠骨質(zhì)疏松性骨折愈合中的作用　出處：《中華中醫(yī)藥雜志》2017年06期 　論文類型：期刊論文

  更多相關(guān)文章： 骨質(zhì)疏松癥 去卵巢 骨質(zhì)疏松性骨折 補(bǔ)腎 健脾 雌二醇

【摘要】：目的:研究補(bǔ)腎、健脾法促進(jìn)去卵巢小鼠骨質(zhì)疏松性骨折愈合的作用,探討中醫(yī)"先天之本""后天之本"理論在骨質(zhì)疏松性骨折防治中的運(yùn)用。方法:建立骨質(zhì)疏松性骨折小鼠模型,隨機(jī)分為生理鹽水組、健脾組、補(bǔ)腎組,分別給予0.9%氯化鈉溶液、健脾方、補(bǔ)腎方灌胃治療,在術(shù)后治療7、14、28d分別處死小鼠、取材,進(jìn)行相關(guān)指標(biāo)檢測(cè),包括血清雌二醇(E_2)和影像學(xué)檢測(cè)。結(jié)果:血清E2檢測(cè)發(fā)現(xiàn),與生理鹽水組比較,補(bǔ)腎組在術(shù)后28d可明顯提高去卵巢小鼠血清E2含量(P0.05);X-Ray線檢測(cè)和Micro-CT掃描三維重建結(jié)果顯示,補(bǔ)腎組和健脾組都能增加骨痂的形成,促進(jìn)骨質(zhì)疏松性骨折的愈合;Micro-CT定量分析結(jié)果顯示,與生理鹽水組比較,補(bǔ)腎組7d時(shí)骨痂BMD of BV,14d時(shí)BV/TV、Conn.D.、BMD of BV、BMD of TV均明顯增加(P0.05),健脾組7、14d時(shí)骨痂BV/TV、BMD of TV亦明顯增加(P0.05)。表明補(bǔ)腎方和健脾方都能提高骨痂的骨量。結(jié)論:補(bǔ)"先天"通過雌激素樣作用,養(yǎng)"后天"可能通過提供血液濡養(yǎng)和促進(jìn)藥物吸收,加速骨質(zhì)疏松性骨折愈合。
[Abstract]:Objective: To study the effect of spleen in mouse ovary, promote the healing of osteoporotic fracture, to explore the Chinese medicine "the birth of the" constitution "theory in osteoporotic fracture prevention in use. Methods: to establish a mouse model of osteoporotic fracture, were randomly divided into saline group, Jianpi Bushen group group. Sodium Chloride Solution, were given 0.9%, Jianpi Bushen decoction, gavage treatment, after treatment of 7,14,28d mice were sacrificed, specimens, the related indexes were detected, including serum estradiol (E_2) test and imaging. Results: the serum E2 detection showed that compared with the normal saline group, Bushen group in postoperative 28d to improve the content of E2 in serum of mouse ovary (P0.05); X-Ray line detection and Micro-CT scan showed that the group of tonifying kidney and strengthening spleen group can increase the callus formation, promote the healing of osteoporotic fracture; the results of quantitative analysis of Micro-CT Show that compared with the normal saline group, Bushen group 7d bone BMD of BV, 14d BV/TV, Conn.D. BMD, of BV, BMD of and TV were significantly increased (P0.05), 7,14d group of invigorating spleen and bone callus BV/TV, BMD of TV also increased significantly (P0.05). That can Jianpi Bushen recipe and to improve the callus bone. Conclusion: the prescription of "innate" by estrogen like effects, have acquired through blood Ruyang and promote drug absorption, accelerate the healing of osteoporotic fracture.

【作者單位】： 上海中醫(yī)藥大學(xué)附屬龍華醫(yī)院;上海中醫(yī)藥大學(xué)脊柱病研究所;
【基金】：國(guó)家自然科學(xué)基金青年基金項(xiàng)目(No.81473701) 上海市科委青年科技啟明星計(jì)劃項(xiàng)目(No.14QA1403500);上海市科委中醫(yī)重點(diǎn)項(xiàng)目(No.15401971700) 上海市衛(wèi)生系統(tǒng)新優(yōu)青培養(yǎng)計(jì)劃項(xiàng)目(No.XYQ2013085) 上海市教育委員會(huì)科研創(chuàng)新項(xiàng)目(No.14YZ051)~~
【分類號(hào)】：R274.1
【正文快照】： 隨著現(xiàn)代醫(yī)學(xué)的發(fā)展,絕經(jīng)后婦女骨質(zhì)疏松癥的防治受到越來越多的關(guān)注。絕經(jīng)后骨質(zhì)疏松癥(postmenopausalosteoporosis,PMOP)是指發(fā)生在絕經(jīng)后婦女中的一種以全身性單位體積內(nèi)骨組織含量減少,骨密度(bone mineral density,BMD)下降及骨組織微結(jié)構(gòu)退行性病變?yōu)樘卣鞯娜硇怨趋?

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