加味都?xì)馔柚委熉宰枞苑渭膊》�(wěn)定期肺腎兩虛證的臨床研究
本文關(guān)鍵詞：加味都?xì)馔柚委熉宰枞苑渭膊》�(wěn)定期肺腎兩虛證的臨床研究 出處：《福建中醫(yī)藥大學(xué)》2016年碩士論文 論文類型：學(xué)位論文
更多相關(guān)文章： 加味都?xì)馔?/b> 慢性阻塞性肺疾病穩(wěn)定期 肺腎兩虛 臨床研究
【摘要】：目的：觀察評估加味都?xì)馔鑼β宰枞苑渭膊》�(wěn)定期肺腎兩虛證患者的癥狀積分、BODE指數(shù)、慢阻肺評估問卷(CAT)評分的影響,以初步探究加味都?xì)馔柚委熉宰枞苑渭膊》�(wěn)定期的臨床療效。方法：本試驗(yàn)選擇符合納入標(biāo)準(zhǔn)的慢性阻塞性肺疾病穩(wěn)定期肺腎兩虛證患者60例,采用隨機(jī)對照的設(shè)計方案分為對照組30例,治療組30例。對照組應(yīng)用吸入噻托溴銨粉霧劑(18ug/吸),治療組在對照組的基礎(chǔ)上加服加味都?xì)馔?療程均為3個月。療程結(jié)束后比較治療前后臨床癥狀積分,體重指數(shù)(BMI)、第1秒用力呼氣容積占預(yù)計值百分比(FEV1%)、呼吸困難分級(mMRC)、6分鐘步行距離(6MWD)、BODE,總積分及慢性阻塞性肺疾病評估測試(CAT)評分的變化。資料收集和整理后采用SPSS 18.0統(tǒng)計軟件進(jìn)行統(tǒng)計學(xué)分析。結(jié)果：1、兩組癥狀積分及療效比較：治療后兩組各個單項癥狀改善均有統(tǒng)計學(xué)差異(P0.05)。治療組與對照組治療后積分比較,除咳嗽、咳痰、喘息、易感冒外,其余指標(biāo)差異有統(tǒng)計學(xué)意義(P0.05)。治療組總有效率為96.42%,對照組總有效率為75%,兩組總有效率差異有統(tǒng)計學(xué)意義。結(jié)果表明治療組治療效果優(yōu)于對照組,尤其在改善乏力、畏寒、腰膝酸軟方面治療組優(yōu)于對照組。2、兩組BODE指數(shù)比較：治療組治療后體重指數(shù)、呼吸困難指數(shù)、6分鐘步行距離、BODE,總積分較治療前差異有統(tǒng)計學(xué)意義(P0.05)。對照組呼吸困難指數(shù)、6分鐘步行距離、BODE,總積分較治療前有統(tǒng)計學(xué)意義(P0.05),其余各項差異無統(tǒng)計學(xué)意義。兩組治療后比較,除治療組呼吸困難指數(shù)、6分鐘步行距離、BODE總積分較對照組差異有統(tǒng)計學(xué)意義(P0.05),其余指標(biāo)均無統(tǒng)計學(xué)意義。結(jié)果表明兩組治療均可以改善患者的呼吸困難程度、6分鐘步行距離、降低BODE指數(shù),且治療組的改善程度優(yōu)于對照組。3、CAT評分比較：兩組治療后分值均較治療前有顯著性差異(P0.05)。兩組治療后分值比較差異亦有統(tǒng)計學(xué)意義(P0.05)。表明經(jīng)過兩組治療均可改善患者的生活質(zhì)量,其中治療組的改善程度優(yōu)于對照組。結(jié)論：加味都?xì)馔杪?lián)合西醫(yī)常規(guī)方案治療慢性阻塞性肺疾病穩(wěn)定期肺腎兩虛證的患者與單純西藥組相比,可以明顯改善患者臨床癥狀,特別是對乏力、畏寒、腰膝酸軟等肺外表現(xiàn)的改善,能明顯提高患者的生活質(zhì)量。
[Abstract]:Objective: To evaluate the modified gas symptom Pill on chronic obstructive pulmonary disease of lung and kidney deficiency syndrome in patients with two points, BODE index, COPD Assessment Questionnaire (CAT) score, clinical curative effect to explore modified gas pill in the treatment of stable chronic obstructive pulmonary disease. Methods: the test select 60 cases of patients with stable chronic obstructive pulmonary disease of lung and kidney deficiency syndrome were incorporated into the standard two, the design scheme of randomly divided into the control group of 30 cases, 30 cases in the treatment group. The control group used Tiotropium Bromide Powder for Inhalation (18ug/ absorption), inhalation treatment group in the control group based on the given modified Duqi pill, treatment for 3 months. After the end of treatment before and after the treatment, clinical symptoms, body mass index (BMI), FEV1 percentage of predicted value (FEV1%), dyspnea grade (mMRC), 6 minutes walking distance (6MWD), BODE, total score and chronic Obstructive pulmonary disease assessment test (CAT) score changes. After collecting and sorting data using SPSS 18 statistical software for statistical analysis. Results: 1, compared with two groups of symptoms and curative effect: there were statistically significant differences between the two groups to improve individual symptoms after treatment (P0.05). Compared with the treatment group and the control group scores after treatment in addition to cough, phlegm, wheezing, colds, other indexes were statistically significant difference (P0.05). The total effective rate of treatment group was 96.42%, control group total effective rate was 75%, the total efficiency of two groups had significant difference. The Meiji therapy effect in treatment group than the control group, especially in the improvement of fatigue, chills the control group,.2 treatment group than Yaoxisuanruan, BODE index of two groups: the treatment group after treatment, body mass index, dyspnea index, 6 minutes walking distance, BODE, the total scores were statistically significant (P0.05) control. Group of dyspnea index, 6 minutes walking distance, BODE, the total scores were statistically significant (P0.05), no statistically significant difference. The rest of the two groups after treatment in treatment group, dyspnea index, 6 minutes walking distance, BODE total score than the control group the difference was statistically significant (P0.05), were no statistical significance of other indexes. The results show that the two groups can improve the patient's respiratory difficulty, 6 minutes walking distance, reduce the BODE index, and the treatment group improved more in the control group.3, CAT score comparison: two groups after treatment the scores were compared with before treatment, there was significant difference in two groups (P0.05). After the score there were significant differences (P0.05). After that the two groups can improve the quality of life of patients, the treatment group improved more in control group. Conclusion: modified Duqi pill combined with conventional western medicine treatment of chronic Compared with obstructive pulmonary disease stable stage two deficiency of lung and kidney of patients with pure western medicine group, can significantly improve the clinical symptoms, especially for fatigue, chills, Yaoxisuanruan extrapulmonary manifestations improved, can significantly improve the quality of life of patients.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259
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