本文關(guān)鍵詞：自擬健脾助運湯治療脾虛濕蘊型潰瘍性結(jié)腸炎療效觀察　出處：《遼寧中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

  更多相關(guān)文章： 潰瘍性結(jié)腸炎 脾虛濕蘊型 臨床療效

【摘要】：目的:以健脾祛濕,調(diào)理氣血為治則,給予脾虛濕蘊型的UC患者自擬方劑健脾助運湯,聯(lián)合美沙拉嗪緩釋顆粒劑口服,觀察對脾虛濕蘊型潰瘍性結(jié)腸炎的臨床治療效果,通過對比患者腸黏膜、臨床癥狀和體征及C反應(yīng)蛋白治療前后的變化,為潰瘍性結(jié)腸炎的中西醫(yī)結(jié)合治療提供臨床研究的依據(jù)。方法:選擇符合納入標準的患者44例,均來自2014年1月至2015年12月期間于遼寧中醫(yī)藥大學附屬醫(yī)院脾胃科住院部的患者。采用隨機數(shù)字表法將患者隨機分為治療組和對照組2個組別,每組患者均為22例。給予兩組患者相同基礎(chǔ)治療的同時,對照組予美沙拉嗪緩釋顆粒劑1.0g,日3次口服;治療組在對照組基礎(chǔ)上另予自擬方藥健脾助運湯100ml,日3次口服,兩組患者療程均為8周。對治療前后2組患者臨床癥狀積分、腸鏡黏膜愈合情況及C反應(yīng)蛋白變化進行比較。數(shù)據(jù)用SPSS17.0統(tǒng)計軟件分析。結(jié)果:1.結(jié)腸鏡腸黏膜改善情況,治療組6例顯效,14例有效,2例無效,總有效率90.91%;對照組4例顯效,10例有效,8例無效,總有效率63.64%,治療組優(yōu)于對照組(P0.05)。2.兩組患者治療前后中醫(yī)癥候積分比較,治療組改善優(yōu)于對照組,差異有統(tǒng)計學意義(P0.05)。中醫(yī)證候療效情況比較,治療組6例臨床痊愈,8例顯效,7例有效,1例無效,總有效率95.24%;對照組4例臨床痊愈,5例顯效,5例有效,8例無效,總有效率63.64%,總有效率相比治療組優(yōu)于對照組(P0.05)。3.兩組療程結(jié)束后,血清C反應(yīng)蛋白比較治療組下降幅度大于對照組,差異有統(tǒng)計學意義(P0.05)。結(jié)論:依據(jù)“腸癰”學術(shù)思想,自擬方藥健脾助運湯以健脾祛濕,調(diào)理氣血為治則,對脾虛濕蘊型潰瘍性結(jié)腸炎進行中西醫(yī)結(jié)合的治療方案,能夠顯著改善患者臨床癥狀,促進病變部位腸黏膜恢復,減輕患者痛苦,提高患者的生存質(zhì)量。
[Abstract]:Objective: to take invigorating spleen and removing dampness and regulating qi and blood as the principle of treatment, to give the UC patients with spleen deficiency and dampness accumulation type self-prescription Jianpi Zhuyun decoction, combined with mesalazine sustained release granule oral administration. To observe the clinical treatment effect of spleen deficiency dampness accumulation type ulcerative colitis, and to compare the changes of intestinal mucosa, clinical symptoms and signs and C-reactive protein before and after treatment. Methods: 44 patients with ulcerative colitis were selected. All the patients from January 2014 to December 2015 in the Department of spleen and stomach of affiliated Hospital of Liaoning University of traditional Chinese Medicine. The patients were randomly divided into two groups: treatment group and control group. 22 patients in each group were treated with the same basic treatment, while the control group was treated with mesalazine sustained release granules (1.0 g, 3 times a day). On the basis of the control group, the treatment group was given 100 ml of Jianpi decoction, three times a day, the course of treatment was 8 weeks. The clinical symptoms of the two groups before and after treatment were scored. The changes of mucosal healing and C-reactive protein in colonoscopy were compared. The data were analyzed by SPSS17.0 software. Results: 1. The improvement of intestinal mucosa in colonoscopy was effective in 14 cases in the treatment group (6 cases). 2 cases were ineffective, the total effective rate was 90.91%; The control group (n = 4) was effective in 10 cases (n = 8) and the total effective rate was 63.64 (n = 8). The treatment group was superior to the control group (P 0.05) .2.The scores of TCM symptoms before and after treatment were compared between the two groups. The improvement in the treatment group was better than that in the control group, and the difference was statistically significant (P 0.05). The curative effect of TCM syndrome in the treatment group was compared. In the treatment group, there were 6 cases of clinical recovery and 8 cases of remarkable effect, 7 cases were effective and 1 case was ineffective. The total effective rate was 95.2445; In the control group, 4 cases were clinically cured, 5 cases were markedly effective, 8 cases were ineffective, the total effective rate was 63.64, the total effective rate was better than that of the control group (P 0.05). 3. After the two treatment courses were finished, the total effective rate of the treatment group was better than that of the control group (P < 0.05). The decrease of serum C-reactive protein in the treatment group was greater than that in the control group, and the difference was statistically significant (P 0.05). Conclusion: according to the academic thought of "intestinal carbuncle", the prescription of Jianpi Juyun decoction was formulated to invigorate the spleen and remove dampness. Regulating qi and blood for the treatment of spleen deficiency and dampness accumulation of ulcerative colitis combined with traditional Chinese and western medicine can significantly improve the clinical symptoms of patients, promote the recovery of intestinal mucosa in the lesion, and alleviate the pain of the patients. Improve the quality of life of patients.
【學位授予單位】：遼寧中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259
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本文編號：1361633